[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1957889-3":169,"verified-suppliers-J-1957889-3":352},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.679814,"live",{"rows":9,"total":167,"current":5,"size":168},[10,33,45,60,73,84,96,111,121,133,145,156],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-6","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-2","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-6","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],10,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-6","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},6,"中国",{"slug":74,"cid":75,"imgSvg":76,"name":77,"nameZh":78,"cas":79,"formula":80,"iupac":77,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":81,"offersCount":25,"supplierCount":25,"bestOffer":82},"785871840001134592","J-982001-3","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":83,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":85,"cid":86,"imgSvg":87,"name":88,"nameZh":89,"cas":90,"formula":91,"iupac":88,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":92,"offersCount":93,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-7","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlLiO2",[23],7,3,{"unitPrice":94,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":94,"supplierCount":5,"bestOffer":109},"785871830249377792","J-6931-8","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[108],"Made to Order",{"unitPrice":110,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},0.56,{"slug":112,"cid":113,"imgSvg":114,"name":115,"nameZh":116,"cas":117,"formula":118,"iupac":115,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":119,"offersCount":69,"supplierCount":25,"bestOffer":120},"785871842446413824","J-1960944-0","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":122,"cid":123,"imgSvg":124,"name":125,"nameZh":126,"cas":127,"formula":128,"iupac":125,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":129,"offersCount":24,"supplierCount":25,"bestOffer":130},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":131,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":134,"cid":135,"imgSvg":136,"name":137,"nameZh":138,"cas":139,"formula":140,"iupac":137,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":141,"offersCount":142,"supplierCount":5,"bestOffer":143},"785871842647740416","J-1333345-4","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],8,{"unitPrice":144,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},11,{"slug":146,"cid":147,"imgSvg":148,"name":149,"nameZh":150,"cas":151,"formula":152,"iupac":149,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":153,"offersCount":57,"supplierCount":94,"bestOffer":154},"785871842698072064","J-814953-9","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],{"unitPrice":155,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":157,"cid":158,"imgSvg":159,"name":160,"nameZh":161,"cas":162,"formula":163,"iupac":160,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":164,"offersCount":94,"supplierCount":5,"bestOffer":165},"785871863254355968","J-1990080-2","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[108],{"unitPrice":166,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,12,{"slug":170,"cid":171,"imgSvg":172,"name":173,"nameZh":174,"cas":175,"formula":176,"iupac":173,"mdl":21,"mw":177,"category":178,"categoryName":179,"categoryEnName":180,"industry":21,"tags":181,"synonyms":182,"properties":193,"ghs":227,"offers":228,"activity":229,"upstream":254,"downstream":255,"customs":256,"safetyRows":269,"toxicity":274,"updatedAt":275,"isProhibited":276,"related":277,"__ts":350,"__lang":351,"__slug":171},"785884668116340736","J-1957889-3","\u002Fimages\u002Fchem_structures_svg\u002F123\u002F65836-72-8.svg","2-Chloro-N-(3,4-dimethoxybenzyl)acetamide","DKM 2-93","65836-72-8","C11H14ClNO3","243.68700","organic","有机化合物","Organic Compounds",[],[183,184,185,186,187,188,189,190,191,192],"2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE","2-氯-N-((3","2-氯-N-((3,4-二甲氧苯基)甲基)乙酰胺","2-氯-N-(3,4-二甲氧基苄基)乙酰胺","2-氯-N-[(3,4-二甲氧苯基)甲基]乙酰胺","2-氯-n-(3,4-二甲氧基苄基)乙酰胺","4-二甲氧苯基)甲基)乙酰胺","UBA5抑制剂(DKM 2-93)","乙酰胺,2-氯-N-((3,4-二甲氧苯基)甲基)-","乙酰胺,2-氯-N-((3,4-二甲氧苯基)甲基)-,10 MM DMSO 溶液",[194,199,204,209,213,216,219,223],{"label":195,"labelZh":196,"value":197,"prop":198},"Boiling Point","沸点","425.7ºC at 760 mmHg","boilingPoint",{"label":200,"labelZh":201,"value":202,"prop":203},"Density","密度","1.194g\u002Fcm3","density",{"label":205,"labelZh":206,"value":207,"prop":208},"Flash Point","闪点","211.3ºC","flashPoint",{"label":210,"labelZh":211,"value":212},"Exact Mass","精确质量","243.06600",{"label":214,"labelZh":214,"value":215},"PSA","47.56000",{"label":217,"labelZh":217,"value":218},"LogP","1.94970",{"label":220,"labelZh":221,"value":222},"Refractive Index","折射率","1.522",{"label":224,"labelZh":225,"value":226},"Storage Conditions","储存条件","2-8℃",null,[],[230,233,236,239,242,245,248,251],{"key":231,"value":232},"描述","DKM 2-93是相对选择性的UBA5抑制剂,IC50值为430 μM。",{"key":234,"value":235},"相关类别","信号通路\n>>\n代谢酶\u002F蛋白酶\n>>\nE1\u002FE2\u002FE3酶\n研究领域\n>>\n癌症",{"key":237,"value":238},"靶点","IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)[1]",{"key":240,"value":241},"体外研究","泛素样修饰物激活酶5(UBA5)是一种新型胰腺癌治疗靶点。 DKM 2-93通过共价修饰UBA5的催化半胱氨酸而损害胰腺癌细胞存活,从而抑制其作为激活遍在蛋白样蛋白UFM1至UFMylate蛋白的蛋白质的活性。 DKM 2-93抑制PaCa2和Panc1细胞存活,IC50分别为90和30μM[1]。",{"key":243,"value":244},"体内研究","DKM 2-93每日治疗在免疫缺陷小鼠的肿瘤异种移植研究中显着损害体内PaCa2细胞的肿瘤生长,而不引起任何体重减轻或明显毒性[1]。",{"key":246,"value":247},"细胞实验","用0-1000μMBHM2-93处理PaCa2和Panc1细胞48小时。通过Hoescht染色评估细胞活力[1]。",{"key":249,"value":250},"动物实验","小鼠：小鼠皮下注射PaCa2细胞以启动肿瘤异种移植研究，并在注射癌细胞后3天用载体或DKM 2-93（50mg \u002F kg ip，每天一次）开始小鼠治疗[1]。",{"key":252,"value":253},"参考文献","[1].\nRoberts AM, et al. Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target. ACS Chem Biol. 2017 Apr 21;12(4):899-904.",[],[],[257,260,263,266],{"key":258,"value":259},"海关编码","2924299090",{"key":261,"value":262},"中文概述","2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%",{"key":264,"value":265},"申报要素","品名, 成分含量, 用途, 包装",{"key":267,"value":268},"Summary","2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%",[270,273],{"key":271,"value":272},"危害码 (欧洲)","Xi",{"key":258,"value":259},"\u003Ctd>\n\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F65836-72-8_583263.html#duXinDiv\">DKM 2-93毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[278,284,290,296,302,308,314,320,326,332,338,344],{"slug":279,"cid":280,"name":281,"nameZh":282,"cas":283},"785880378626805760","J-1974556-3","Pidotimod","匹多莫德","121808-62-6",{"slug":285,"cid":286,"name":287,"nameZh":288,"cas":289},"785883686766645248","J-8750-3","D-Biotin","D-生物素","58-85-5",{"slug":291,"cid":292,"name":293,"nameZh":294,"cas":295},"785875461283516416","J-1030078-4","1,1,7,7-Tetramethyl-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol","1,1,7,7-四甲基-8-羟基久洛尼定","115704-83-1",{"slug":297,"cid":298,"name":299,"nameZh":300,"cas":301},"785876833009668096","J-14831-2","Aluminum n-butoxide","正-丁氧基铝","3085-30-1",{"slug":303,"cid":304,"name":305,"nameZh":306,"cas":307},"785884196030648320","J-23062-6","Amobam","代森铵","3566-10-7",{"slug":309,"cid":310,"name":311,"nameZh":312,"cas":313},"785893522262724608","J-35353-7","Anethole trithione","茴三硫","532-11-6",{"slug":315,"cid":316,"name":317,"nameZh":318,"cas":319},"785897851497484288","J-1029313-7","Lead cyanamide","氨基氰铅(2+)盐(1:1)","20837-86-9",{"slug":321,"cid":322,"name":323,"nameZh":324,"cas":325},"785872113025159168","J-1991060-2","Diphenamid","草乃敌","957-51-7",{"slug":327,"cid":328,"name":329,"nameZh":330,"cas":331},"785897799613943808","J-47958-3","Sudan I","苏丹Ⅰ","842-07-9",{"slug":333,"cid":334,"name":335,"nameZh":336,"cas":337},"785898485864992768","J-50492-7","Fibrinogen (Bovine)","纤维蛋白原","9001-32-5",{"slug":339,"cid":340,"name":341,"nameZh":342,"cas":343},"785873393281929216","J-1107012-5","Dropropizine","羟丙哌嗪","17692-31-8",{"slug":345,"cid":346,"name":347,"nameZh":348,"cas":349},"785897360059273216","J-1453000-8","1,10-Phenanthroline-2,9-dicarbaldehyde","1,10-菲啰啉-2,9-二甲醛","57709-62-3",1794260719816,"zh-CN",[]]