[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1957881-5":169,"verified-suppliers-J-1957881-5":331},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.679814,"live",{"rows":9,"total":167,"current":5,"size":168},[10,33,45,60,73,84,96,111,121,133,145,156],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-6","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-2","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-6","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],10,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-6","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},6,"中国",{"slug":74,"cid":75,"imgSvg":76,"name":77,"nameZh":78,"cas":79,"formula":80,"iupac":77,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":81,"offersCount":25,"supplierCount":25,"bestOffer":82},"785871840001134592","J-982001-3","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":83,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":85,"cid":86,"imgSvg":87,"name":88,"nameZh":89,"cas":90,"formula":91,"iupac":88,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":92,"offersCount":93,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-7","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlLiO2",[23],7,3,{"unitPrice":94,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":94,"supplierCount":5,"bestOffer":109},"785871830249377792","J-6931-8","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[108],"Made to Order",{"unitPrice":110,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},0.56,{"slug":112,"cid":113,"imgSvg":114,"name":115,"nameZh":116,"cas":117,"formula":118,"iupac":115,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":119,"offersCount":69,"supplierCount":25,"bestOffer":120},"785871842446413824","J-1960944-0","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":122,"cid":123,"imgSvg":124,"name":125,"nameZh":126,"cas":127,"formula":128,"iupac":125,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":129,"offersCount":24,"supplierCount":25,"bestOffer":130},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":131,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":134,"cid":135,"imgSvg":136,"name":137,"nameZh":138,"cas":139,"formula":140,"iupac":137,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":141,"offersCount":142,"supplierCount":5,"bestOffer":143},"785871842647740416","J-1333345-4","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],8,{"unitPrice":144,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},11,{"slug":146,"cid":147,"imgSvg":148,"name":149,"nameZh":150,"cas":151,"formula":152,"iupac":149,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":153,"offersCount":57,"supplierCount":94,"bestOffer":154},"785871842698072064","J-814953-9","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],{"unitPrice":155,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":157,"cid":158,"imgSvg":159,"name":160,"nameZh":161,"cas":162,"formula":163,"iupac":160,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":164,"offersCount":94,"supplierCount":5,"bestOffer":165},"785871863254355968","J-1990080-2","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[108],{"unitPrice":166,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,12,{"slug":170,"cid":171,"imgSvg":172,"name":173,"nameZh":174,"cas":175,"formula":176,"iupac":173,"mdl":21,"mw":177,"category":178,"categoryName":179,"categoryEnName":180,"industry":21,"tags":181,"synonyms":182,"properties":185,"ghs":216,"offers":217,"activity":218,"upstream":237,"downstream":238,"customs":239,"safetyRows":252,"toxicity":254,"updatedAt":255,"isProhibited":256,"related":257,"__ts":329,"__lang":330,"__slug":171},"785884646763139072","J-1957881-5","\u002Fimages\u002Fchem_structures_svg\u002F235\u002F35711-34-3.svg","Tolmetin sodium","托美丁钠","35711-34-3","C15H14NNaO3","279.26600","organic","有机化合物","Organic Compounds",[],[183,184],"痛灭定钠","1-甲基-5-(4-甲基苯甲酰基)-1H-吡咯-2-乙酸钠盐",[186,191,196,201,206,210,213],{"label":187,"labelZh":188,"value":189,"prop":190},"Melting Point","熔点","155-157ºC (DECOMPOSES)","meltingPoint",{"label":192,"labelZh":193,"value":194,"prop":195},"Boiling Point","沸点","483.2ºC at 760 mmHg","boilingPoint",{"label":197,"labelZh":198,"value":199,"prop":200},"Density","密度","1.18g\u002Fcm3","density",{"label":202,"labelZh":203,"value":204,"prop":205},"Flash Point","闪点","246ºC","flashPoint",{"label":207,"labelZh":208,"value":209},"Exact Mass","精确质量","279.08700",{"label":211,"labelZh":211,"value":212},"PSA","62.13000",{"label":214,"labelZh":214,"value":215},"LogP","0.85690",null,[],[219,222,225,228,231,234],{"key":220,"value":221},"描述","托美汀钠是一种口服有效的COX抑制剂,其IC50分别为0.35µM和0.82µM人COX-1和COX-2。托美汀钠是一种非甾体抗炎药(NSAID)[1][2]。",{"key":223,"value":224},"相关类别","研究领域\n>>\n癌症\n研究领域\n>>\n炎症\u002F免疫\n信号通路\n>>\n免疫及炎症\n>>\nCOX",{"key":226,"value":227},"靶点","Human COX-1:0.35 μM (IC50)\nHuman COX-2:0.82 μM (IC50)",{"key":229,"value":230},"体外研究","托美汀钠(0.25mM)不能减轻大鼠脑匀浆中的脂质过氧化。托美汀(0.25、0.5、0.75、1mM)具有清除自由基的特性,但在大鼠脑匀浆中不产生超氧阴离子[3]。托美汀钠(0.001-100μM)对HT-29结肠癌细胞系具有剂量依赖性的抗癌活性[4]。托美汀钠(0-100μM)对成骨细胞生长没有影响[5]。",{"key":232,"value":233},"体内研究","托美汀钠(30100mg\u002Fkg；灌胃；单剂量或每日两次,持续3天和14天)在单剂量后4小时显示出最大的溃疡形成作用,而在体重为180-200g的雄性Wistar大鼠中,重复给药3天后和14天后,其显著降低。托美汀以100mg\u002Fkg引起胃损伤[2]。托美汀钠(5 mg\u002Fkg,每天两次,共5天)预处理显著减轻喹啉酸(QA)诱导的神经毒性[3]。",{"key":235,"value":236},"参考文献","[1].\nT D Warner, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7563-8.\n[2].\nEtcheverry SB, et al. Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin). Bioactivity on osteoblast-like cells in culture. J Inorg Biochem. 2002 Jan 1;88(1):94-100.\n[3].\nDADAŞ, Yakup, et al. Synthesis and anticancer activity of some novel tolmetin thiosemicarbazides. Marmara Pharmaceutical Journal 19(3) • April 2015",[],[],[240,243,246,249],{"key":241,"value":242},"海关编码","2933990090",{"key":244,"value":245},"中文概述","2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":247,"value":248},"申报要素","品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期",{"key":250,"value":251},"Summary","2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[253],{"key":241,"value":242},"\u003Ctd>\n\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F35711-34-3_581493.html#duXinDiv\">托美丁钠毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[258,263,269,275,281,287,293,299,305,311,317,323],{"slug":259,"cid":260,"name":261,"nameZh":261,"cas":262},"785900657373614080","J-1622860-7","8-Chloro-1-phenyldibenzofuran","809274-52-0",{"slug":264,"cid":265,"name":266,"nameZh":267,"cas":268},"785898686344335360","J-1174132-5","Pigment Red 83","颜料红 83","104074-25-1",{"slug":270,"cid":271,"name":272,"nameZh":273,"cas":274},"785882735708213248","J-5581-2","METHYL CALCEIN BLUE","甲基钙黄绿素","54696-41-2",{"slug":276,"cid":277,"name":278,"nameZh":279,"cas":280},"785896051272847360","J-43479-7","Methyl Calcein Blue Hydrate [Indicator for complexometry Copper]","甲基钙黄绿素蓝水合物[用于配位滴定铜时的指示剂]","81028-96-8",{"slug":282,"cid":283,"name":284,"nameZh":285,"cas":286},"785891525505585152","J-1106993-5","Sudan II","苏丹红 II","3118-97-6",{"slug":288,"cid":289,"name":290,"nameZh":291,"cas":292},"785882284585652224","J-2888-6","Zineb","代森锌","12122-67-7",{"slug":294,"cid":295,"name":296,"nameZh":297,"cas":298},"785884649673986048","J-23784-3","Ammonium ferrocyanide","亚铁氰化铵","14481-29-9",{"slug":300,"cid":301,"name":302,"nameZh":303,"cas":304},"785889602677248000","J-1959100-5","Ataluren","阿塔鲁伦","775304-57-9",{"slug":306,"cid":307,"name":308,"nameZh":309,"cas":310},"785894546700505088","J-37940-8","Phloretin","根皮素","60-82-2",{"slug":312,"cid":313,"name":314,"nameZh":315,"cas":316},"785894562861158400","J-38022-3","Luteolin","木犀草素","491-70-3",{"slug":318,"cid":319,"name":320,"nameZh":321,"cas":322},"785876366082969600","J-1973301-8","alpha-Arbutin","α-熊果苷","84380-01-8",{"slug":324,"cid":325,"name":326,"nameZh":327,"cas":328},"785872087020474368","J-1990991-2","Alizarin Yellow R","茜素黄R","2243-76-7",1794267559089,"zh-CN",[]]