[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1957485-9":171,"verified-suppliers-J-1957485-9":322},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.689327,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":179,"synonyms":180,"properties":186,"ghs":202,"offers":203,"activity":204,"upstream":232,"downstream":275,"customs":276,"safetyRows":277,"updatedAt":281,"isProhibited":282,"related":283,"__ts":320,"__lang":321,"__slug":173},"785884248908238848","J-1957485-9","\u002Fimages\u002Fchem_structures_svg\u002F253\u002F1140909-48-3.svg","卡博替尼苹果酸盐","1140909-48-3","C32H30FN3O10","635.593",[],[181,182,183,184,185],"苹果酸卡博替尼","卡博替尼S-苹果酸盐","N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]苯基]-N'-(4-氟苯基)-1,1-环丙烷二甲酰胺 (S)-苹果酸盐","XL-184(苹果酸盐)","L-苹果酸卡博替尼",[187,191,195,198],{"label":188,"labelZh":189,"value":190},"Exact Mass","精确质量","635.191528",{"label":192,"labelZh":193,"value":194},"PSA","其他信息","193.61000",{"label":196,"labelZh":196,"value":197},"LogP","4.59340",{"label":199,"labelZh":200,"value":201},"Storage Conditions","储存条件","室温，干燥，密封",null,[],[205,208,211,214,217,220,223,226,229],{"key":206,"value":207},"描述","Cabozantinib (S-malate)是一种有效的多受体酪氨酸激酶抑制剂, 抑制VEGFR2,c-Met,Kit,Axl 和 Flt3 的 IC50 分别为0.035,1.3,4.6,7 和 11.3 nM。",{"key":209,"value":210},"相关类别","研究领域\n>>\n癌症",{"key":212,"value":213},"靶点","VEGFR2:0.035 nM (IC50)",{"key":215,"value":216},"体外研究","XL184(0.1-0.5μM)抑制所有MPNST细胞中的组成型和诱导型MET磷酸化及其产生的下游信号传导。 XL184(>0.1μM)引起显着的MPNST细胞生长抑制;需要更高的XL184剂量来抑制NSC生长。 XL184处理阻断HGF诱导的MPNST运动和侵袭(在NSC上发现的类似作用)[2]。在细胞试验中,cabozantinib抑制MET和VEGFR2以及KIT,FLT3和AXL的磷酸化,IC50值分别为7.8,1.9,5.0,7.5和42μM。 Cabozantinib还响应来自MDA-MB-231(IC50 = 5.1 nM),A431(IC50 = 4.1 nM),HT1080(IC50 = 7.7 nM)和B16F10(IC50 = 4.7 nM)培养物的条件培养基抑制小管形成细胞[3]。",{"key":218,"value":219},"体内研究","卡博替尼(60mg\u002Fkg,ip)降低肿瘤血管分布,在动物中降低范围从3mg\u002Fkg的67％至30mg\u002Fkg的83％。与载体的相应值[1]相比,在10周龄开始治疗7天的RIP-Tag2小鼠中的肿瘤在XL880后小40％,在XL184后小35％。 XL184(30 mg\u002Fkg)显着降低小鼠的微血管密度[2]。卡博替尼(100mg\u002Fkg,口服)抑制体内刺激肝脏肝细胞中HGF的MET磷酸化和VEGF刺激的FLK1磷酸化,同时抑制持续8小时后的两种靶标。卡博替尼(100mg\u002Fkg,口服)破坏肿瘤血管系统并促进肿瘤和内皮细胞死亡。 Cabozantinib(1-60 mg\u002Fkg,po)抑制肿瘤生长并促进体内肿瘤消退[3]。",{"key":221,"value":222},"激酶实验","使用荧光素酶偶联的化学发光，33P-磷酰基转移或AlphaScreen技术测定卡博替尼对270种人激酶的广泛组的抑制特性。使用重组人全长，谷胱甘肽S-转移酶标签或组氨酸标签融合蛋白，并通过测量在ATP浓度等于或低于该浓度的肽底物聚（Glu，Tyr）的磷酸化来确定半数最大抑制浓度（IC50）值。每种激酶的Km。通过测定ATP浓度范围内的IC 50值，使用AlphaScreen Assay评估激酶抑制的机制。",{"key":224,"value":225},"细胞实验","将细胞在含有10％FBS的培养基中一式三份接种过夜。第二天，用连续稀释的卡博替尼处理细胞48小时，然后使用细胞增殖ELISA，BrdUrd分析增殖。",{"key":227,"value":228},"动物实验","将H441细胞（3×106）皮内植入后腹部，当肿瘤达到约150mg时，使用下式计算肿瘤重量:(肿瘤体积=长度（mm）×宽度2（mm2）] \u002F 2，小鼠随机分组（每组n = 5）并口服单剂量100mg \u002F kg剂量的cabozantinib或载体。在指定的时间点收集肿瘤。用抗MET（SC161）对合并的肿瘤裂解物进行免疫沉淀，并用抗蛋白质印迹法进行免疫沉淀。 -phosphotyrosine MET（pY1230 \u002F 34\u002F35）。在印迹剥离后，将总MET定量为上样对照。在单独的实验中，给予幼稚小鼠（每组n = 5）单次100mg \u002F kg剂量的cabozantinib或在收集肝脏前10分钟静脉注射HGF（每只小鼠10μg），肝脏裂解液中的MET磷酸化分析如上所述。在另一项实验中，幼稚小鼠（每组n = 5）给予单一100 mg \u002F kg剂量的cabozantinib或载体，然后在肺采集前30分钟静脉内施用VEGF（每只小鼠10μg）。汇集的肺裂解物用FLK1（SC6251）进行免疫沉淀，并用抗磷酸酪氨酸（4G10）进行蛋白质印迹。印迹剥离后，定量总FLK1作为上样对照。",{"key":230,"value":231},"参考文献","[1].\nYou WK, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res, 2011, 71(14), 4758-4768.\n[2].\nTorres KE, et al. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clin Cancer Res, 2011, 17(12), 3943-3955.\n[3].\nYakes FM, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011, 10(12), 2298-2308.",[233,239,245,251,257,263,269],{"slug":234,"cid":235,"name":236,"nameZh":236,"cas":237,"imgSvg":238},"785894654561226800","J-38487-0","L-苹果酸","97-67-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F033\u002F97-67-6.svg",{"slug":240,"cid":241,"name":242,"nameZh":242,"cas":243,"imgSvg":244},"785884249076011000","J-1957488-2","卡博替尼","849217-68-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F212\u002F849217-68-1.svg",{"slug":246,"cid":247,"name":248,"nameZh":248,"cas":249,"imgSvg":250},"785889704103907300","J-1370300-4","4-羟基-6,7-二甲氧基喹啉","13425-93-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F242\u002F13425-93-9.svg",{"slug":252,"cid":253,"name":254,"nameZh":254,"cas":255,"imgSvg":256},"785888948437127200","J-1357847-5","4-氯-6,7-二甲氧基喹啉","35654-56-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F291\u002F35654-56-9.svg",{"slug":258,"cid":259,"name":260,"nameZh":260,"cas":261,"imgSvg":262},"785880676393029600","J-16730-7","1,1-环丙基二羧酸","598-10-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F246\u002F598-10-7.svg",{"slug":264,"cid":265,"name":266,"nameZh":266,"cas":267,"imgSvg":268},"785894677013336000","J-38576-9","4-氟苯胺","371-40-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F119\u002F371-40-4.svg",{"slug":270,"cid":271,"name":272,"nameZh":272,"cas":273,"imgSvg":274},"785891127940091900","J-1473898-0","1-(4-氟苯基氨基甲酰基)环丙烷羧酸","849217-48-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F136\u002F849217-48-7.svg",[],[],[278],{"key":279,"value":280},"危害码 (欧洲)","Xi","2026-08-21T07:51:12.859463Z",false,[284,290,296,302,308,314],{"slug":285,"cid":286,"name":287,"nameZh":288,"cas":289},"785895479245279232","J-40685-3","(+)-1,2-Bis((2S,5S)-2,5-dimethylphospholano)benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate","(+)-1,2-双((2S,5S)-2,5-二甲基磷杂环戊烷)苯(1,5-环辛二烯)铑(I)四氟硼酸盐","205064-10-4",{"slug":291,"cid":292,"name":293,"nameZh":294,"cas":295},"785873050238193664","J-1334589-3","Calcium ricinoleate","蓖麻油酸钙","6865-33-4",{"slug":297,"cid":298,"name":299,"nameZh":300,"cas":301},"785875669346160640","J-10727-7","Phenylmercuric nitrate, basic","碱性硝酸苯汞","8003-05-2",{"slug":303,"cid":304,"name":305,"nameZh":306,"cas":307},"785941873792389120","J-678046-1","Bis(dipropoxyphosphinodithioic acid) lead(II) salt","双(二丙氧基二硫代磷酸)铅(II)","43159-15-5",{"slug":309,"cid":310,"name":311,"nameZh":312,"cas":313},"785895861367345152","J-1512131-4","Ytterbium(III) trifluoromethanesulfonate hydrate","三氟甲烷磺酸镱水合物","252976-51-5",{"slug":315,"cid":316,"name":317,"nameZh":318,"cas":319},"785884213017579520","J-23118-5","Bismuth 2-ethylhexanoate","2-乙基己酸铋","67874-71-9",1792674455397,"zh-CN",[]]