[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1956667-7":169,"verified-suppliers-J-1956667-7":345},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.679814,"live",{"rows":9,"total":167,"current":5,"size":168},[10,33,45,60,73,84,96,111,121,133,145,156],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-6","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-2","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-6","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],10,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-6","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},6,"中国",{"slug":74,"cid":75,"imgSvg":76,"name":77,"nameZh":78,"cas":79,"formula":80,"iupac":77,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":81,"offersCount":25,"supplierCount":25,"bestOffer":82},"785871840001134592","J-982001-3","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":83,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":85,"cid":86,"imgSvg":87,"name":88,"nameZh":89,"cas":90,"formula":91,"iupac":88,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":92,"offersCount":93,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-7","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlLiO2",[23],7,3,{"unitPrice":94,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":94,"supplierCount":5,"bestOffer":109},"785871830249377792","J-6931-8","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[108],"Made to Order",{"unitPrice":110,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},0.56,{"slug":112,"cid":113,"imgSvg":114,"name":115,"nameZh":116,"cas":117,"formula":118,"iupac":115,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":119,"offersCount":69,"supplierCount":25,"bestOffer":120},"785871842446413824","J-1960944-0","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":122,"cid":123,"imgSvg":124,"name":125,"nameZh":126,"cas":127,"formula":128,"iupac":125,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":129,"offersCount":24,"supplierCount":25,"bestOffer":130},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":131,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":134,"cid":135,"imgSvg":136,"name":137,"nameZh":138,"cas":139,"formula":140,"iupac":137,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":141,"offersCount":142,"supplierCount":5,"bestOffer":143},"785871842647740416","J-1333345-4","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],8,{"unitPrice":144,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},11,{"slug":146,"cid":147,"imgSvg":148,"name":149,"nameZh":150,"cas":151,"formula":152,"iupac":149,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":153,"offersCount":57,"supplierCount":94,"bestOffer":154},"785871842698072064","J-814953-9","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],{"unitPrice":155,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":157,"cid":158,"imgSvg":159,"name":160,"nameZh":161,"cas":162,"formula":163,"iupac":160,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":164,"offersCount":94,"supplierCount":5,"bestOffer":165},"785871863254355968","J-1990080-2","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[108],{"unitPrice":166,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,12,{"slug":170,"cid":171,"imgSvg":172,"name":173,"nameZh":174,"cas":175,"formula":176,"iupac":173,"mdl":21,"mw":177,"category":178,"categoryName":179,"categoryEnName":180,"industry":21,"tags":181,"synonyms":182,"properties":185,"ghs":227,"offers":228,"activity":229,"upstream":245,"downstream":264,"customs":266,"safetyRows":267,"updatedAt":268,"isProhibited":269,"related":270,"__ts":343,"__lang":344,"__slug":171},"785883488116019200","J-1956667-7","\u002Fimages\u002Fchem_structures_svg\u002F243\u002F1033805-22-9.svg","Telotristat ethyl","特罗司他乙酯","1033805-22-9","C27H26ClF3N6O3","574.982","esters","酯类","Esters",[],[183,184],"LX 1606","泰乐曲丝坦",[186,191,196,201,205,208,211,215,219,223],{"label":187,"labelZh":188,"value":189,"prop":190},"Boiling Point","沸点","704.7±70.0 °C at 760 mmHg","boilingPoint",{"label":192,"labelZh":193,"value":194,"prop":195},"Density","密度","1.4±0.1 g\u002Fcm3","density",{"label":197,"labelZh":198,"value":199,"prop":200},"Flash Point","闪点","380.0±35.7 °C","flashPoint",{"label":202,"labelZh":203,"value":204},"Exact Mass","精确质量","574.170715",{"label":206,"labelZh":206,"value":207},"PSA","131.17000",{"label":209,"labelZh":209,"value":210},"LogP","5.47",{"label":212,"labelZh":213,"value":214},"Appearance","外观性状","白色固体",{"label":216,"labelZh":217,"value":218},"Vapor Pressure","蒸汽压","0.0±2.2 mmHg at 25°C",{"label":220,"labelZh":221,"value":222},"Refractive Index","折射率","1.621",{"label":224,"labelZh":225,"value":226},"Storage Conditions","储存条件","-20°C，密闭，干燥",null,[],[230,233,236,239,242],{"key":231,"value":232},"描述","Telotristat ethyl (LX1606) 是一种可口服的色氨酸羟化酶抑制剂,能够减少血清素的产生。",{"key":234,"value":235},"相关类别","信号通路\n>>\n代谢酶\u002F蛋白酶\n>>\n色氨酸羟化酶\n研究领域\n>>\n神经疾病",{"key":237,"value":238},"体内研究","Telotristat乙基(15,50,150,300mg\u002Fkg,po,qd)降低外周血清素含量,但不降低小鼠脑中血清素含量。 Telotristat乙基(200mg\u002Fkg po,qd)防止在TNBS攻击后观察到的血液中性粒细胞计数的增加,在炎性肠病的小鼠模型中提供显着的保护。 Telotristat乙基(200 mg\u002Fkg po,qd)保护小鼠IBD模型,通过组织病理学评估证实[1]。 Telotristat乙基(15,50,150,300 mg\u002Fkg)从空肠消耗5-HT,但不消耗大脑。但是Telotristat乙基(200mg\u002Fkg,口服)不会消耗肠神经元5-羟色胺(5-HT),或改变小鼠的组成型胃肠动力。 Telotristat乙基(200 mg\u002Fkg)可减轻三硝基苯磺酸(TNBS)诱导的结肠炎的严重程度[2]。",{"key":240,"value":241},"动物实验","为了研究外周TPH抑制剂对肠道和脑5-HT浓度的影响，将LP-920540配制在0.25％甲基纤维素的0.1％吐温80中，并通过口服管饲法以10 mL \u002F kg连续4天给予小鼠一次。 。将Telotristat乙基配制在15％环糊精（CaptisolTM，pH 3-4）或0.25％甲基纤维素中，并通过口服管饲法以10mL \u002F kg连续4天给予小鼠一次。收集全脑，空肠和结肠（取出肠系膜脂肪，打开肠腔并吸干），快速冷冻，并储存在-80℃以备将来使用。 LP-920540，Telotristat乙基，LP-778914，LP-778920和媒介物对照也在编码小瓶中以适当剂量用0.5％甲基纤维素配制。通过口服强饲法给出编码小瓶的内容物，其量由受体小鼠的重量确定。在实验之后，分析结果。",{"key":243,"value":244},"参考文献","[1].\nTamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model.\n[2].\nMargolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.",[246,252,258],{"slug":247,"cid":248,"name":249,"nameZh":249,"cas":250,"imgSvg":251},"785891931673595900","J-1754715-8","甲醇","67-56-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F233\u002F67-56-1.svg",{"slug":253,"cid":254,"name":255,"nameZh":255,"cas":256,"imgSvg":257},"785893833480081400","J-1327518-8","乙醇","64-17-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F081\u002F64-17-5.svg",{"slug":259,"cid":260,"name":261,"nameZh":261,"cas":262,"imgSvg":263},"785895276308074500","J-1978968-5","LX1606马尿酸盐","1137608-69-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F090\u002F1137608-69-5.svg",[265],{"slug":259,"cid":260,"name":261,"nameZh":261,"cas":262,"imgSvg":263},[],[],"2026-08-21T07:51:12.859463Z",false,[271,277,283,289,295,301,307,313,319,325,331,337],{"slug":272,"cid":273,"name":274,"nameZh":275,"cas":276},"785880917334822912","J-1094636-8","Polysorbate 80","聚山梨酯80","9005-65-6",{"slug":278,"cid":279,"name":280,"nameZh":281,"cas":282},"785893769781186560","J-36209-4","Sodium methylparaben","尼泊金甲酯钠","5026-62-0",{"slug":284,"cid":285,"name":286,"nameZh":287,"cas":288},"785872476956528640","J-1339868-0","beta-Butyrolactone","β-丁内酯","3068-88-0",{"slug":290,"cid":291,"name":292,"nameZh":293,"cas":294},"785894459526090752","J-1013905-6","tralocythrin","溴氯氰菊酯","66841-26-7",{"slug":296,"cid":297,"name":298,"nameZh":299,"cas":300},"785883275397697536","J-1956385-0","Atorvastatin Methyl Ester","阿托伐他汀甲酯","345891-62-5",{"slug":302,"cid":303,"name":304,"nameZh":305,"cas":306},"785892527747108864","J-1492553-2","Olmesartan Medoxomil Impurity E","奥美沙坦酯杂质E","144689-78-1",{"slug":308,"cid":309,"name":310,"nameZh":311,"cas":312},"785896554178285568","J-1406967-1","Olmesartan medoxomil methyl ether","奥美沙坦酯甲醚","896419-17-3",{"slug":314,"cid":315,"name":316,"nameZh":317,"cas":318},"785892365066833920","J-1492151-8","Difebarbamate","苯巴氨酯","15687-09-9",{"slug":320,"cid":321,"name":322,"nameZh":323,"cas":324},"785881021940764672","J-1975297-7","Prednisolone Farnesylate","泼尼松龙法呢酯","118244-44-3",{"slug":326,"cid":327,"name":328,"nameZh":329,"cas":330},"785898503875334144","J-1188531-7","Pentacosanyl myristate","肉豆蔻二十五烷酯","121877-45-0",{"slug":332,"cid":333,"name":334,"nameZh":335,"cas":336},"785882336196562944","J-805408-8","Telmisartan tert-butyl ester","替米沙坦叔丁酯","144702-26-1",{"slug":338,"cid":339,"name":340,"nameZh":341,"cas":342},"785935976198311936","J-566440-4","SiR-NHS Ester","SiR-NHS酯","1808181-14-7",1794265813536,"zh-CN",[]]