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\u003C0.01)\u002Fkg)在小鼠中提出了这样的假设,即可能需要更长时间的治疗以使突触发挥有效功能[1]。",{"key":243,"value":244},"激酶实验","使用闪烁亲近测定和动力学分析测定GSK3β，Cdk2和Cdk5 Ki。对GSK3β测定进行GSK3α测定。用于计算GSKα的Ki值的ATP的KM值为10μM。进行Cdk1的抑制。用于计算Ki值的ATP的KM值为51μM。使用Ser \u002F Thr激酶SPA试剂盒，p42 MAPK激酶（20U \u002F孔）和生物素化的MBP测定Erk2活性。用于计算Ki值的ATP的KM值为71μM[1]。",{"key":246,"value":247},"动物实验","小鼠[1]使用总共161只雄性C57BL \u002F 6小鼠，8-12周龄。将动物保持在常规壳体中（每笼3-5只小鼠）并随意喂食标准啮齿动物咀嚼物和自来水。通常在每个实验组中包括9-12只小鼠，在卫星组中包括2-4只小鼠（用于测定血浆和脑中的化合物暴露，见下文）。 AZD1080（4.0或15μmol\u002F kg）或载体（含0.5％抗坏血酸，0.01％EDTA，pH2.0的水）通过口服强饲法（10mL \u002F kg）急性或间歇性（每天两次）给药3天。在用AZD1080最终施用后1.5,3或5小时进行训练试验。为了破坏学习，在训练试验前30分钟，小鼠接受皮下施用MK-801（0.1或0.15mg \u002F kg;（+） -  MK.801马来酸氢盐）或载体（盐水）。大鼠[1]使用总共71只成年雄性Sprague-Dawley大鼠（250-300g）。通过口服强饲法（给药体积5mL \u002F kg）给大鼠接受急性剂量的AZD1080（1,3或10μmol\u002F kg）或载体（含0.5％抗坏血酸的水，0.01％EDTA，pH2.0）。在给药后1,2,3,6或24小时，麻醉大鼠，并将来自腹主动脉的血液在肝素微量管中取样。从血液样品中分离外周血单核细胞（PBMC）。获得单独的血液样品用于血浆处理和随后的生物分析。",{"key":249,"value":250},"参考文献","[1].\nGeorgievska B, et al. 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