[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1956443-2":171,"verified-suppliers-J-1956443-2":305},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":188,"ghs":227,"offers":228,"activity":229,"upstream":251,"downstream":258,"customs":259,"safetyRows":260,"updatedAt":264,"isProhibited":265,"related":266,"__ts":303,"__lang":304,"__slug":173},"785883325779677184","J-1956443-2","\u002Fimages\u002Fchem_structures_svg\u002F461\u002F219989-84-1.svg","伊沙匹隆","219989-84-1","C27H42N2O5S","506.698","organic","有机化合物","Organic Compounds",[],[184,185,186,187],"伊莎匹隆","依沙匹隆","依沙比酮","CS-1169",[189,194,199,204,208,212,215,219,223],{"label":190,"labelZh":191,"value":192,"prop":193},"Boiling Point","沸点","697.8±55.0 °C at 760 mmHg","boilingPoint",{"label":195,"labelZh":196,"value":197,"prop":198},"Density","密度","1.1±0.1 g\u002Fcm3","density",{"label":200,"labelZh":201,"value":202,"prop":203},"Flash Point","闪点","375.8±31.5 °C","flashPoint",{"label":205,"labelZh":206,"value":207},"Exact Mass","精确质量","506.281433",{"label":209,"labelZh":210,"value":211},"PSA","其他信息","140.29000",{"label":213,"labelZh":213,"value":214},"LogP","1.77",{"label":216,"labelZh":217,"value":218},"Vapor Pressure","蒸汽压","0.0±2.3 mmHg at 25°C",{"label":220,"labelZh":221,"value":222},"Refractive Index","折射率","1.533",{"label":224,"labelZh":225,"value":226},"Storage Conditions","储存条件","-20 °C",null,[],[230,233,236,239,242,245,248],{"key":231,"value":232},"描述","Ixabepilone 是一种可口服的 microtubule抑制剂,能够与微管蛋白结合,促进微管蛋白的聚合和微管的稳定,因此使细胞停滞在 G2-M 期,诱导细胞凋亡。",{"key":234,"value":235},"相关类别","信号通路\n>>\n细胞周期\u002FDNA损伤\n>>\n微管\u002F微管蛋白\n信号通路\n>>\n细胞骨架\n>>\n微管\u002F微管蛋白\n研究领域\n>>\n癌症",{"key":237,"value":238},"体外研究","BMS-247550是一种高效的细胞毒性剂,能够以低纳摩尔浓度杀死癌细胞,并保留其对抗紫杉醇天然不敏感或对紫杉醇具有抗性的人类癌症的抗肿瘤活性[1]。",{"key":240,"value":241},"体内研究","在紫杉醇抗性和敏感性肿瘤中,BMS-247550显示出优于紫杉醇的抗肿瘤活性。在本研究中评估的所有五种紫杉醇抗性肿瘤中,BMS-247550比紫杉醇更有效(四种人和一种鼠)：临床上衍生的紫杉醇抗性Pat-7卵巢癌,A2780Tax卵巢癌,由于微管蛋白而对紫杉醇具有抗性突变,HCT116\u002FVM46 MDR结肠癌,临床衍生的紫杉醇抗性Pat-21乳腺癌和鼠纤维肉瘤M5076。针对三种对紫杉醇敏感的人肿瘤异种移植物,BMS-247550产生与紫杉醇相当的抗肿瘤活性：A2780人卵巢癌,HCT116和LS174T人结肠癌[1]。",{"key":243,"value":244},"激酶实验","通过已公布的技术评估BMS-247550和紫杉醇聚合从小牛脑中分离的微管蛋白的效力。简言之，将不同浓度的紫杉醇或BMS-247550在聚合缓冲液[0.1M mes，1mM EGTA，0.5mM MgCl 2（pH6.6）]中在37℃下在Beckman的微量试管孔中加入聚合缓冲液中的微管蛋白中。型号DU 7400紫外分光光度计。使用1.0mg \u002F mL的最终微管蛋白质浓度和通常2.5,5.0和10μM的化合物浓度。通过仪器附带的软件程序计算每10秒测量的吸光度（A280 nM）变化的初始斜率。",{"key":246,"value":247},"细胞实验","在暴露于7.5nm的BMS-247550后1,2,4,8,16和24小时通过胰蛋白酶消化收集来自培养物的HCT116细胞。将细胞沉淀并在-20℃下在80％乙醇中固定。在-20℃下储存过夜后，用PBS缓冲液再水化细胞，并通过与碘化丙锭（5μg\u002F mL）在0.1％RNase中孵育15-30分钟进行DNA染色。使用FACS Calibur仪器进行荧光激活细胞分选仪采集，并使用Cellquest和Modfit软件进行分析。",{"key":249,"value":250},"参考文献","[1].\nJohn T. Hunt Discovery of Ixabepilone. Mol Cancer Ther February 2009 8; 275",[252],{"slug":253,"cid":254,"name":255,"nameZh":255,"cas":256,"imgSvg":257},"785895034695192600","J-1977754-0","埃博霉素B","152044-54-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F476\u002F152044-54-7.svg",[],[],[261],{"key":262,"value":263},"危害码 (欧洲)","Xi","2026-08-21T07:51:12.859463Z",false,[267,273,279,285,291,297],{"slug":268,"cid":269,"name":270,"nameZh":271,"cas":272},"785892233441185792","J-1960577-5","Mupirocin lithium","莫匹罗星锂","73346-79-9",{"slug":274,"cid":275,"name":276,"nameZh":277,"cas":278},"785898319007191040","J-50207-4","Cellulase","纤维素酶","9012-54-8",{"slug":280,"cid":281,"name":282,"nameZh":283,"cas":284},"785875919876132864","J-11268-8","Bis(tri-tert-butylphosphine)palladium(0)","双(三叔丁基膦)钯(0)","53199-31-8",{"slug":286,"cid":287,"name":288,"nameZh":289,"cas":290},"785875803232538624","J-1044195-4","Copper(II) ionophore I","铜(II) 离子载体 I","125769-67-7",{"slug":292,"cid":293,"name":294,"nameZh":295,"cas":296},"785883051367337984","J-6801-5","Chromotrope 2B","铬变素2B","548-80-1",{"slug":298,"cid":299,"name":300,"nameZh":301,"cas":302},"785884049620078592","J-22716-8","Cobalt phthalocyanine","酞菁钴","3317-67-7",1792646607847,"zh-CN",[]]