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TPX2复合物在激酶反应中进行。",{"key":250,"value":251},"细胞实验","将MM细胞系与DMSO或Alisertib（0.125-0.5μM）一起与常规抗MM剂美法仑（2.5-5μM），多柔比星（50-100nM）或地塞米松（50-100nM）一起温育;并用新型抗MM剂硼替佐米（2.5-5nM）或来那度胺（0.5-1μM）72小时。通过MTT测定法测量细胞活力。组合指数（CI）通过使用CalcuSyn软件2.0版的等效线图分析确定（CI \u003C1表示协同效应; CI = 1，加性效应;和CI> 1，没有显着的组合效应）。",{"key":253,"value":254},"动物实验","照射小鼠（200cGy），然后在右胁腹皮下接种5×106MM1.S细胞。当肿瘤生长可测量时（注射后2周），将小鼠分成4组（每组10只小鼠）口服载体（100μL10％2-羟丙基-β-环糊精\u002F 1％碳酸氢钠）或Alisertib（7.5）最终制剂中的mg \u002F kg，15mg \u002F kg和30mg \u002F kg，在10％2-羟丙基-β-环糊精\u002F 1％碳酸氢钠中）连续21天。 Alisertib在大多数小鼠品系中的最大耐受剂量（连续给药21天）约为20mg \u002F kg，每天两次（40mg \u002F kg每天）。每隔一天通过游标卡尺测量肿瘤体积，并使用以下公式计算：长度×宽度2×0.5。在治疗结束时，最后一次治疗后2小时或肿瘤达到2 cm3时处死小鼠;立即从小鼠收集肿瘤，并通过TdT介导的dUTP缺口末端标记（TUNEL）测定评估诱导细胞凋亡和细胞死亡。",{"key":256,"value":257},"参考文献","[1].\nGüllü G, et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma Blood June 24, 2010 vol. 115 no. 25 5202-5213\n[2].\nSloane DA, et al. Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237 ACS Chem. Biol., 2010, 5 (6), pp 563-576\n[3].\nManfredi MG, et al. Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays.Clin Cancer Res. 2011 Dec 15;17(24):7614-7624.\n[4].\nYayi Feng, et al. Targeting aurora a kinase (AURKA) and P21-activated kinase 1 (PAK1) in hormone receptor-positive breast cancer. College of Medicine. Drexel University. 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