[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1956154-1":171,"verified-suppliers-J-1956154-1":296},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.689327,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":185,"ghs":224,"offers":225,"activity":226,"upstream":251,"downstream":252,"customs":253,"safetyRows":254,"updatedAt":255,"isProhibited":256,"related":257,"__ts":294,"__lang":295,"__slug":173},"785882906194087936","J-1956154-1","\u002Fimages\u002Fchem_structures_svg\u002F261\u002F897383-62-9.svg","N-[4-[[3-氯-4-[(3-氟苯基)甲氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯酰胺","897383-62-9","C24H18ClFN4O2","448.877","bases","有机碱","Organic Bases",[],[184,175],"艾力替尼",[186,191,196,201,205,209,212,216,220],{"label":187,"labelZh":188,"value":189,"prop":190},"Boiling Point","沸点","655.0±55.0 °C at 760 mmHg","boilingPoint",{"label":192,"labelZh":193,"value":194,"prop":195},"Density","密度","1.4±0.1 g\u002Fcm3","density",{"label":197,"labelZh":198,"value":199,"prop":200},"Flash Point","闪点","349.9±31.5 °C","flashPoint",{"label":202,"labelZh":203,"value":204},"Exact Mass","精确质量","448.110229",{"label":206,"labelZh":207,"value":208},"PSA","其他信息","79.63000",{"label":210,"labelZh":210,"value":211},"LogP","5.02",{"label":213,"labelZh":214,"value":215},"Vapor Pressure","蒸汽压","0.0±2.0 mmHg at 25°C",{"label":217,"labelZh":218,"value":219},"Refractive Index","折射率","1.700",{"label":221,"labelZh":222,"value":223},"Storage Conditions","储存条件","2-8℃",null,[],[227,230,233,236,239,242,245,248],{"key":228,"value":229},"描述","AST1306是选择性,不可逆的 EGFR 和 ErbB2 抑制剂,IC50 值分别为0.5 和 3 nM。",{"key":231,"value":232},"相关类别","研究领域\n>>\n癌症",{"key":234,"value":235},"靶点","EGFR:0.5 nM (IC50)\nErbB2:3 nM (IC50)\nEGFRL858R\u002FT790M:12 nM (IC50)",{"key":237,"value":238},"体外研究","AST1306诱导HIH3T3-EGFR T790M\u002FL858R细胞生长的显着的浓度依赖性抑制。此外,AST1306有效抑制HIH3T3-EGFR T790M\u002FL858R细胞中的EGFR磷酸化。 AST1306以浓度依赖性方式抑制携带EGFR T790M\u002FL858R突变的NCI-H1975细胞的生长,并阻断EGFR和下游途径的磷酸化。 AST1306抑制人癌细胞中EGFR和ErbB2的磷酸化以及下游信号传导。 AST1306抑制人癌细胞的增殖,过量表达ErbB2的细胞表现出更高的敏感性[1]。",{"key":240,"value":241},"体内研究","AST1306有效抑制过表达ErbB2的腺癌异种移植物和FVB-2\u002FNneu转基因乳腺癌小鼠模型中的肿瘤生长,但弱抑制EGFR过表达肿瘤异种移植物的生长。在SK-OV-3异种移植模型中由单剂量AST1306诱导的肿瘤生长抑制伴随着EGFR和ErbB2的快速(在2小时内)和持续(≥24小时)抑制,这与不可逆的抑制机制一致[ 1]。",{"key":243,"value":244},"细胞实验","将细胞接种到96孔板中并生长24小时。然后用递增浓度的AST1306处理细胞并再生长72小时。使用SRB（磺酰罗丹明B）测定评估细胞增殖[1]。",{"key":246,"value":247},"动物实验","小鼠：给予小鼠AST1306，剂量为100,50和25mg \u002F kg，每天两次，并用拉帕替尼（50mg \u002F kg）作为对照。使用卡尺每周两次测量肿瘤，并根据公式L×W×W \u002F 2 [1]计算肿瘤体积。",{"key":249,"value":250},"参考文献","[1].\nXie H, Lin L, Tong L et al. AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. PLoS One. 2011;6(7):e21487.",[],[],[],[],"2026-08-21T07:51:12.859463Z",false,[258,264,270,276,282,288],{"slug":259,"cid":260,"name":261,"nameZh":262,"cas":263},"785880649671118848","J-1975000-2","Rhodamine B hydrazide","罗丹明B酰肼","74317-53-6",{"slug":265,"cid":266,"name":267,"nameZh":268,"cas":269},"785888648779272192","J-25452-8","N,N'-Didodecyldithiooxamide","双十二烷基二硫代乙二酰胺","120-88-7",{"slug":271,"cid":272,"name":273,"nameZh":274,"cas":275},"785884521533804544","J-1312949-9","Di-μ-hydroxo-bis[(N,N,N',N'-tetramethylethylenediamine)copper(II)] chloride","二-μ-羟基-双[(N,N,N',N'-四甲基乙二胺)铜(II)]氯化物","30698-64-7",{"slug":277,"cid":278,"name":279,"nameZh":280,"cas":281},"785898617306091520","J-1604743-5","EUK-189","N,N'-双(3-乙氧基亚水杨基)-1,2-乙二胺-锰(II)","186350-27-6",{"slug":283,"cid":284,"name":285,"nameZh":286,"cas":287},"785898498833780736","J-1528294-1","Cesium(I) bis(trifluoromethanesulfonyl)imide","双(三氟甲基磺酰基)酰亚胺铯(I)","91742-16-4",{"slug":289,"cid":290,"name":291,"nameZh":292,"cas":293},"785875602539286528","J-10557-8","Tris(ethylenediamine)cobalt(III) chloride trihydrate","三(乙二胺)氯化钴(III)三水合物","14883-80-8",1792653675836,"zh-CN",[]]