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[1]，使用非线性回归，S形剂量反应进行IC50（EC50）计算，将顶部约束至100％，将底部约束至0％，允许可变斜率。",{"key":244,"value":245},"动物实验","小鼠[1]每周给雄性小鼠腹膜内注射MTX（1mg \u002F kg）或载体（PBS）4周。通过皮下注射3mL无菌空气产生气囊，并在2天后用1.5mL无菌空气再充气。将载体（0.5％羧甲基纤维素和0.25％吐温80）或Apremilast（5mg \u002F kg）口服给药，用注射器通过钝端弯曲的进料管，在第6天通过注射诱导炎症之前24小时和1小时。 1 mL 2％角叉菜胶悬浮液。 4小时后，小鼠被CO2麻醉死亡，并用2 mL PBS收获渗出物。在血细胞计数器室中计数白细胞，并通过ELISA或Luminex平台测量细胞因子的浓度。大鼠[2]雄性Sprague Dawley大鼠（180-220g）用于研究Apremilast的药代动力学。在实验前12小时禁止饮食，但可以免费饮用水。在口服Apremilast后0.25,0.5,0.75,1,1.5,2,3,4,6,8和12小时从尾静脉收集血液样品（0.3mL）到肝素化的1.5mL聚乙烯管中（6.0mg \u002F公斤）。将样品立即以4,000g离心8分钟。将获得的血浆（100μL）储存在-20℃直至分析。通过DAS（药物和统计学）软件分析每只大鼠的血浆Apremilast浓度对时间数据。",{"key":247,"value":248},"参考文献","[1].\nPerez-Aso M, et al. 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