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\u002F kg的口服剂量分别以2.5,25,50和250mg \u002F mL的浓度配制在Imwitor 742-Tween 80（1：1，w \u002F w）中。在以下时间点将血液样品（0.3mL）收集到含EDTA的管中：给药前和0.083（仅静脉内），给药后0.25,0.5,1,2,4,6,8,24和48小时。将血液样品储存在冰上，通过离心制备血浆。将血浆转移至96孔板中并在-70℃下储存直至分析。",{"key":254,"value":255},"参考文献","[1].\nNiesor EJ, et al. Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport. J Lipid Res. 2010, 51(12), 3443-3454.\n[2].\nDong B, et al. CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism. Atherosclerosis. 2014 Aug;235(2):449-62.\n[3].\nTan EY, et al. Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys. 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