[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1955628-6":171,"verified-suppliers-J-1955628-6":309},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":186,"ghs":225,"offers":226,"activity":227,"upstream":252,"downstream":265,"customs":266,"safetyRows":267,"updatedAt":268,"isProhibited":269,"related":270,"__ts":307,"__lang":308,"__slug":173},"785882233146707968","J-1955628-6","\u002Fimages\u002Fchem_structures_svg\u002F415\u002F395104-30-0.svg","3-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑","395104-30-0","C22H24N6O","388.466","pharma","医药中间体","Pharma Intermediates",[],[184,185],"化合物 CC-401","CC-401",[187,192,197,202,206,210,213,217,221],{"label":188,"labelZh":189,"value":190,"prop":191},"Boiling Point","沸点","681.5±65.0 °C at 760 mmHg","boilingPoint",{"label":193,"labelZh":194,"value":195,"prop":196},"Density","密度","1.3±0.1 g\u002Fcm3","density",{"label":198,"labelZh":199,"value":200,"prop":201},"Flash Point","闪点","366.0±34.3 °C","flashPoint",{"label":203,"labelZh":204,"value":205},"Exact Mass","精确质量","388.201172",{"label":207,"labelZh":208,"value":209},"PSA","其他信息","82.72000",{"label":211,"labelZh":211,"value":212},"LogP","3.74",{"label":214,"labelZh":215,"value":216},"Vapor Pressure","蒸汽压","0.0±2.1 mmHg at 25°C",{"label":218,"labelZh":219,"value":220},"Refractive Index","折射率","1.660",{"label":222,"labelZh":223,"value":224},"Storage Conditions","储存条件","2-8℃",null,[],[228,231,234,237,240,243,246,249],{"key":229,"value":230},"描述","CC-401是第二代ATP竞争性JNK抑制剂,具有抗肿瘤活性。",{"key":232,"value":233},"相关类别","研究领域\n>>\n癌症",{"key":235,"value":236},"靶点","JNK:25-50 nM (Ki)",{"key":238,"value":239},"体外研究","与其他相关激酶相比,CC-401对JNK的选择性至少为40倍,包括p38,细胞外信号调节激酶(ERK),κB激酶抑制剂(IKK2),蛋白激酶C,Lck,zeta相关蛋白70 kDa(ZAP70)。在基于细胞的测定中,1至5μMCC-401提供特异性JNK抑制。 CC-401,一种小分子,是所有三种JNK同种型的特异性抑制剂。 CC-401竞争性结合JNK中的ATP结合位点,导致抑制转录因子c-Jun的N-末端激活结构域的磷酸化。使用HK-2人肾小管上皮细胞系的渗透压在体外测试该抑制剂的特异性。 CC-401以剂量依赖性方式抑制山梨糖醇诱导的c-Jun磷酸化。然而,CC-401不能阻止山梨醇诱导的JNK,p38或ERK的磷酸化[1]。",{"key":241,"value":242},"体内研究","与对照相比,在贝伐单抗和奥沙利铂治疗中适度诱导p-JNK的染色,并且在CC-401处理的样品中,p-cJun含量显着更低,与有效的JNK抑制一致。与CC-401联合治疗时DNA损伤适度升高[2]。从第7天到第24天的CC-401治疗减缓了蛋白尿的进展,与第14天和第21天的未治疗组和赋形剂组相比,蛋白尿显着减少。然而,在第21天,蛋白尿的程度仍然增加。 CC-401处理的大鼠在第5天与蛋白尿相比。载体和未处理组在第24天发生肾损伤,如血清肌酸酐的增加所示。这可以通过CC-401治疗来预防[3]。",{"key":244,"value":245},"细胞实验","将人HK-2近端小管上皮细胞培养在补充有10％FCS，10ng \u002F mL EGF和10μg\u002F mL牛垂体提取物的DMEM \u002F F12培养基中。对于Western印迹研究，将细胞接种到六孔板中并使其粘附过夜，并将培养基更换为仅补充有0.5％FCS的DMEM \u002F F12 24小时，此时细胞汇合。 CC-401在柠檬酸（pH5.5）中制备，并在加入300mM山梨糖醇前1小时加入汇合细胞中，30分钟后用尿素-RIPA缓冲液收获细胞。进行三个实验，每个实验在每个条件下重复两次。对于ELISA实验，将HK-2细胞接种到24孔板中，使其粘附过夜，在含有0.5％FCS的DMEM \u002F F12中培养24小时，然后用CC-401或载体孵育60分钟，然后用1刺激。 μM血管紧张素II（AngII）。 48小时后收获上清液，并使用商业ELISA试剂盒测定TGF-β1含量。进行三个实验，每个实验使用每个条件重复六次[1]。",{"key":247,"value":248},"动物实验","小鼠[2]为了评估CC-401在小鼠异种移植模型中抗血管生成和奥沙利铂联合治疗中JNK信号传导抑制的功效，使用成年（8-10周龄）雌性严重联合免疫缺陷小鼠（CB17 SCID） 。为了产生肿瘤，将HT29细胞（1×10 6个细胞）皮下注射到小鼠的左侧腹中。当肿瘤达到约200mm 3时，将小鼠分成8组（每组8只小鼠）用贝伐单抗，奥沙利铂，CC401和贝伐单抗，奥沙利铂和CC-401的适当组合进行治疗。贝伐单抗治疗组中的小鼠每3天通过腹膜内注射接受5mg \u002F kg贝伐单抗，持续21天。奥沙利铂治疗组每周腹腔注射5mg \u002F kg奥沙利铂，持续2周。 CC-401治疗组每3天腹腔注射25mg \u002F kg。联合治疗组接受贝伐单抗（每3天，5mg \u002F kg），奥沙利铂（每周2周，5mg \u002F kg）和CC-401（每3天，25mg \u002F kg）。对照组腹腔注射生理盐水。每3天测量肿瘤体积和体重。计算肿瘤体积。肿瘤生长延迟计算为对照和治疗肿瘤从200到800mm3生长的时间差。对于肿瘤生长延迟计算，小鼠继续接受治疗直至肿瘤体积达到800mm 3。对于免疫组织化学，在第9天处理后处死小鼠用于肿瘤处理和染色。大鼠[3]使用雌性WKY大鼠（180-220g）。通过尾静脉注射绵羊抗大鼠GBM血清5天后（称为第0天）皮下注射弗氏完全佐剂中的5mg绵羊IgG免疫9或10只大鼠组。在该研究中，在抗GBM血清给药后7天，在9或10只大鼠的组中开始CC-401（200mg \u002F kg \u002F通过口服强饲法）或载体（柠檬酸钠）处理，并且此后每天持续两次直至动物。第24天处死。在抗GBM血清注射后第7天或第24天杀死未处理的另外一组大鼠作为对照。将动物饲养在代谢笼中22小时以在第5,14和21天收集尿液。在死亡时收集血液。进行血清肌酐和尿蛋白的分析。",{"key":250,"value":251},"参考文献","[1].\nMa FY, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 2007 Feb;18(2):472-84.\n[2].\nVasilevskaya IA, et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res. 2015 Sep 15;21(18):4143-52.\n[3].\nMa FY, et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest. 2009 Apr;89(4):470-84.",[253,259],{"slug":254,"cid":255,"name":256,"nameZh":256,"cas":257,"imgSvg":258},"785882955036758000","J-6277-2","N,N-二甲基甲酰胺二甲基缩醛","4637-24-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F209\u002F4637-24-5.svg",{"slug":260,"cid":261,"name":262,"nameZh":262,"cas":263,"imgSvg":264},"785882577071247400","J-4819-2","1-(2-羟乙基)哌啶","3040-44-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F461\u002F3040-44-6.svg",[],[],[],"2026-08-21T07:51:12.859463Z",false,[271,277,283,289,295,301],{"slug":272,"cid":273,"name":274,"nameZh":275,"cas":276},"785880888364765184","J-1084897-7","zinc bis(piperidine-1-carbodithioate)","(T-4)-双(1-哌啶二硫代羧酸-S,S’)-锌","13878-54-1",{"slug":278,"cid":279,"name":280,"nameZh":281,"cas":282},"785876809550925824","J-14681-0","Cetylpyridinium bromide","溴代十六烷基吡啶","140-72-7",{"slug":284,"cid":285,"name":286,"nameZh":287,"cas":288},"785898911599431680","J-1192729-1","Bis(2,2'-bipyridine)copper(2+)","双(2,2'-联吡啶)铜(II)离子","16787-11-4",{"slug":290,"cid":291,"name":292,"nameZh":293,"cas":294},"785888546626998272","J-25146-8","1-butyl-3-methylimidazolium hexafluoroantimonate","1-丁基-3-甲基咪唑六氟锑酸盐","174645-81-9",{"slug":296,"cid":297,"name":298,"nameZh":299,"cas":300},"785894733439307776","J-38841-4","Chloro(pyridine)bis(dimethylglyoximato)cobalt(III)","氯双(二甲基乙二肟)吡啶钴(III)","23295-32-1",{"slug":302,"cid":303,"name":304,"nameZh":305,"cas":306},"785876265667137536","J-12852-8","Bis(pyridine)iodonium tetrafluoroborate","双(吡啶)四氟硼化碘","15656-28-7",1792647898709,"zh-CN",[]]