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= 99),光滑念珠菌(n = 18)和热带假丝酵母(n = 10)分离株的MIC均≤0.32μg\u002F mL。 Anidulafungin对曲霉菌种也具有活性(90％的菌株被抑制的最低有效浓度,0.02μg\u002F mL)(n = 20),对近平滑念珠菌的活性较低(MIC中90％的菌株被抑制[ MIC90],5.12μg\u002F mL)(n = 10),对新生隐球菌(MIC90>10.24μg\u002F mL)(n = 15)和B. dermatitidis(MIC90,16μg\u002F mL)无效(n = 29)氟康唑对3种热带假丝酵母菌株,7株光滑念珠菌和2株克鲁斯念珠菌的MIC均≥16μg\u002F mL。 Anidulafungin对这12个菌株中的11个的MIC为0.08-0.32mg\u002FmL。第十二菌株是克芜菁菌株(氟康唑MIC,32μg\u002F mL),其中Anidulafungin MIC为1.28mg\u002FmL。对于这12种菌株,90％的分离株被抑制的MIC(MIC90)为0.32μg\u002F mL。其余18株光滑芽孢杆菌分离株和氟利昂霉素分离物的Anidulafungin MIC90(FluconazoleMICs≥8μg\u002F mL)也为0.32 mg\u002FmL。 Anidulafungin对氟康唑MICs≥16mg\u002F mL的念珠菌属物种和氟康唑MICs≥8μg\u002F mL的念珠菌物种具有同样的活性。 Anidulafungin对C. neoformans和B. dermatitidis的活性显着低于对C. albicans,C。glabrata和C. tropicalis的活性。酮康唑和两性霉素B是针对新生隐球菌和皮肤癣菌测试的最活跃的抗真菌剂。 Anidulafungin表现出对Aspergillus物种的有效体外活性,MEC90为0.02μg\u002F mL。对照菌株酵母分离物中的Anidulafungin的MIC对于白色念珠菌ATCC 90028为0.02μg\u002F mL,对于C. glabrata ATCC 90030为0.16 mg\u002FmL,对于C. neoformans ATCC 90112为>10.24μg\u002F mL [1]。用CD101选择的CD101 MIC增加2倍或更多的菌株对于Anidulafungin(ANF)和\u002F或Caspofungin(CSF)的MIC增加至少2倍[2]。",{"key":243,"value":244},"细胞实验","CD101（以前的SP 3025，biafungin，AF-025）的库存在使用前在100％DMSO中新鲜制备。比较抗真菌剂Anidulafungin（ANF），Caspofungin（CSF）和两性霉素B（AMB）也在100％DMSO中制备。根据CLSI指南，通过肉汤微量稀释进行MIC测定，不同的是测试化合物以50倍最终测定浓度配制，并使用100μL测定混合物体积（2μL添加至含有细胞的98μL含肉细胞0.5μL） ×103至2.5×103CFU \u002F mL）。所有MIC测定至少运行三次，并显示代表性数据集。在整个研究中通过比较针对AMB，CSF和ANF的WT C.krusei菌株ATCC 6258得到的MIC值与先前报道的CLSI 24-h肉汤微量稀释QC范围来评估质量控制（QC）[2]。",{"key":246,"value":247},"参考文献","[1].\nZhanel GG, et al. In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species. Antimicrob Agents Chemother. 1997 Apr;41(4):863-5\n[2].\nLocke JB, et al. Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species. 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