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irritation \u002F 造成皮肤刺激","H317 — May cause an allergic skin reaction \u002F 可能造成皮肤过敏反应","H318 — Causes serious eye damage \u002F 造成严重眼损伤","H334 — May cause allergy or asthma symptoms if inhaled \u002F 吸入可能导致过敏或哮喘病症状","H335 — May cause respiratory irritation \u002F 可能造成呼吸道刺激","H341 — Suspected of causing genetic defects \u002F 怀疑可造成遗传性缺陷","H361 — Suspected of damaging fertility or the unborn child \u002F 怀疑对生育能力或胎儿造成伤害",[],[264,267,270,273,276,279,282,285,288],{"key":265,"value":266},"描述","Paclitaxel是一种有效的抗癌药物,可以促进微管 (microtubule (MT)) 组装,抑制MT解聚,并改变有丝分裂和细胞增殖所需的微管动力学。",{"key":268,"value":269},"相关类别","信号通路\n>>\n抗体- 药物偶联物\n>>\nADC细胞毒素\n信号通路\n>>\n细胞周期\u002FDNA损伤\n>>\n微管\u002F微管蛋白\n信号通路\n>>\n细胞骨架\n>>\n微管\u002F微管蛋白\n研究领域\n>>\n癌症\n天然产物\n>>\n萜类化合物和糖苷",{"key":271,"value":272},"靶点","IC50: 4 nM (MT)",{"key":274,"value":275},"体外研究","0.1,0.5和1μM的紫杉醇以剂量依赖的方式降低CCRF-HSB-2细胞的增殖和存活,并且紫杉醇的IC50值约为0.25μM[1]。紫杉醇直接与内质网结合,刺激钙释放到细胞质中,有助于诱导细胞凋亡[2]。",{"key":277,"value":278},"体内研究","在SCID小鼠异种移植模型中,低剂量节律性紫杉醇治疗可减少EGI-1细胞的肺传播,而不会显着影响其局部肿瘤生长[3]。低剂量的紫杉醇促进小鼠异种移植物中的肝转移,这与宿主肝脏中雌激素代谢的变化相关[4]。紫杉醇(每次治疗2 mg\u002Fkg,黑眼圈)在后爪的无毛皮肤中诱导机械超敏反应[5]。",{"key":280,"value":281},"激酶实验","为了确定哪种半胱天冬酶参与紫杉醇，半胱天冬酶-3抑制剂（DEVD-CHO），半胱天冬酶-6抑制剂（Z-VEID-FMK），半胱天冬酶-8抑制剂（Z-IETD-FMK或IETD-CHO）诱导的细胞凋亡，使用胱天蛋白酶-9抑制剂（Z-LEHD-FMK或LEHD-CHO）和半胱天冬酶-10抑制剂（Z-AEVD-FMK）。将这些半胱天冬酶抑制剂溶于二甲基亚砜（Me2SO）中; Me2SO的最终浓度为0.1％。将细胞（5×105）在存在或不存在100μM这些抑制剂的情况下于37℃预孵育3小时，然后用或不用0.1,0.5和1μM紫杉醇处理48小时并处理用于膜联蛋白V结合测定。",{"key":283,"value":284},"细胞实验","在存在或不存在浓度增加的（0.1-1μM）紫杉醇的96孔板中将1×10 4个细胞接种在100μL生长培养基中，并在37℃，5％CO 2中培养12-48小时。然后将细胞与25μLMTT（5mg \u002F mL）在37℃下孵育4小时。用0.04N HCl的异丙醇溶解晶体后，在酶标仪中在570nm处读板。从细胞存活图确定抑制细胞存活50％（IC50）的药物浓度。",{"key":286,"value":287},"动物实验","成年（250-320g）雄性Sprague-Dawley大鼠用于所有实验。在12小时：12小时光照：黑暗的时间表中，在温度和湿度受控的情况下，每笼饲养两只大鼠，随意提供食物和水。注射DiI后一周，用异氟烷麻醉大鼠，并用2mg \u002F kg紫杉醇或其载体（1：1：23，cremophor EL：乙醇：0.9％盐水）注射到尾静脉中。尾静脉注射每隔一天重复三次，共注射四次。",{"key":289,"value":290},"参考文献","[1].\nPark SJ, et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3;279(49):51057-67. Epub 2004 Sep 27.\n[2].\nPan Z, et al. Paclitaxel attenuates Bcl-2 resistance to apoptosis in breast cancer cells through an endoplasmic reticulum-mediated calciumrelease in a dosage dependent manner. Biochem Biophys Res Commun. 2013 Feb 13. pii: S0006-291X(13)00259-3.\n[3].\nCadamuro M, et al. Low dose paclitaxel reduces S100A4 nuclear import to inhibit invasion and hematogenous metastasis of cholangiocarcinoma. Cancer Res. 2016 Jun 21.\n[4].\nLi Q, et al. Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model. FEBS J. 2016 Jun 16.\n[5].\nYilmaz E, et al. Sensory neuron subpopulation-specific dysregulation of intracellular calcium in a rat model of chemotherapy-induced peripheral neuropathy. Neuroscience. 2015 Aug 6;300:210-8.\n[6].\nJing C, et al. Lenvatinib enhances the antitumor effects of paclitaxel in anaplastic thyroid cancer. Am J Cancer Res. 2017 Apr 1;7(4):903-912.",[292,298],{"slug":293,"cid":294,"name":295,"nameZh":295,"cas":296,"imgSvg":297},"785873646085214200","J-1027548-6","紫杉醇缩合物","158722-23-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F045\u002F158722-23-7.svg",{"slug":299,"cid":300,"name":301,"nameZh":301,"cas":302,"imgSvg":303},"785882963127570400","J-6329-6","4-二甲氨基吡啶","1122-58-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F498\u002F1122-58-3.svg",[305,311,317,323,329],{"slug":306,"cid":307,"name":308,"nameZh":308,"cas":309,"imgSvg":310},"785882469432823800","J-4202-4","10-脱乙酰基巴卡丁 III；...","32981-86-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F256\u002F32981-86-5.svg",{"slug":312,"cid":313,"name":314,"nameZh":314,"cas":315,"imgSvg":316},"785876135492718600","J-1972966-9","(2R,3S)-3-苯甲酰氨基...","32981-85-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F294\u002F32981-85-4.svg",{"slug":318,"cid":319,"name":320,"nameZh":320,"cas":321,"imgSvg":322},"785895555980070900","J-42097-3","巴卡丁III","27548-93-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F324\u002F27548-93-2.svg",{"slug":324,"cid":325,"name":326,"nameZh":326,"cas":327,"imgSvg":328},"785883276169449500","J-1956390-7","7-表紫杉醇","105454-04-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F175\u002F105454-04-4.svg",{"slug":330,"cid":331,"name":332,"nameZh":332,"cas":333,"imgSvg":334},"785892722455089200","J-1961643-4","10-去乙酰紫杉醇","78432-77-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F476\u002F78432-77-6.svg",[336],{"key":337,"value":338},"海关编码","2932999021",[340,343,345,348,351,354,357,360,363,366,369,372,375,378],{"key":341,"value":342},"符号","GHS05, GHS07, GHS08",{"key":344,"value":253},"信号词",{"key":346,"value":347},"危害声明","H315-H317-H318-H334-H335-H341-H361",{"key":349,"value":350},"警示性声明","P261-P280-P284-P304 + P340-P305 + P351 + P338 + P310-P342 + P311",{"key":352,"value":353},"个人防护装备","Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges",{"key":355,"value":356},"危害码 (欧洲)","Xn:Harmful",{"key":358,"value":359},"风险声明 (欧洲)","R40;R41",{"key":361,"value":362},"安全声明 (欧洲)","22-26-36\u002F37\u002F39-45",{"key":364,"value":365},"危险品运输编码","1544",{"key":367,"value":368},"WGK德国","3",{"key":370,"value":371},"RTECS号","DA8340700",{"key":373,"value":374},"包装等级","III",{"key":376,"value":377},"危险类别","6.1(b)",{"key":337,"value":338},"\u003Cp>1.紫杉醇的制造方法有三种。第一种是合成法，第二种是细菌培养法，第三种是从红豆杉中直接分离制取。前两种方法虽已取得重大研究成果，但均未实现产业化，目前从天然或栽培的红豆杉中分离仍是生产紫杉醇的主要途径。其分离过程一般是甲醇或乙醇浸出(或超离界提取)→己烷脱酯→二氯甲烷或氯仿萃取得粗提物→多次硅胶柱层析→制备性HPLC、TLC、HSCCC纯化→重结晶得产品。由于硅胶柱层析很难将紫杉醇与另一衍生物Cephalomannine分开且产品收率低，Kingston等人采用O3选择性氧化Cephalomannine分子中的烯键，然后再经硅胶柱层析将紫杉醇纯化。近年来，采用高分子树脂进行红豆杉粗提物的脱色及分离取得很大进度，克服了原各种分离方法收率低、产量小、成本高、生长周期长等问题。\u003C\u002Fp>\u003Cp>2. 7-三乙基硅烷10-脱乙酰巴卡亭Ⅲ的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入10-脱乙酰卡巴亭Ⅲ1.0g(1.8mmol)和无水吡啶100ml,搅拌溶解,在通N2保护下,缓慢滴加三乙基氯硅烷6.7ml(6.0g,40mmol),滴毕#反应液呈黄色#降温至0ºC,于0ºC下搅拌反应24h.加乙酸乙酯200ml和水200ml,充分搅拌后静置分层,分取有机层,用饱和硫酸铜溶液(300ml×3),洗涤,直至将过量的吡啶全部除去,用水100ml洗涤,再用饱和NaCl水溶液100ml洗涤,无水Na2SO4干燥,过滤,滤液减压蒸除溶剂,浓缩剩余物经230~400目硅胶-60(Merck)柱色谱纯化,用二氯甲烷\u002F甲醇(体积比99:1)洗脱#得化合物7-三乙基硅烷10-脱乙酰巴卡亭Ⅲ1.12g,收率79%,mp256~257 ºC(二氯甲烷\u002F戊烷).\u003C\u002Fp>\u003Cp>3. 7-三乙基硅烷巴卡亭Ⅲ的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入化合物7-三乙基硅烷10-脱乙酰巴卡亭Ⅲ1.0g(1.5mmol)和无水吡啶43ml,降温至0ºC,搅拌滴加乙酰氯0.6ml,滴毕,仍在0ºC下继续搅拌反应20h.加乙酸乙酯和水各50ml,充分搅拌,静置分层,用乙酸乙酯(30ml×2)提取水相,合并有机相,用饱和硫酸铜溶液洗涤至吡啶完全除去,然后依次序用水洗、饱和氯化钠溶液洗涤. 无水NaSO4干燥,过滤,将滤液减压浓缩,浓缩剩余液经230~400目硅胶-60(Merck)柱色谱纯化[洗脱剂:二氯甲烷\u002F甲醇(体积比99:1)],得7-三乙基硅烷巴卡亭Ⅲ1.03g, 收率86%,mp253~254ºC(二氯甲烷\u002F戊烷).\u003C\u002Fp>\u003Cp>4. [2aR-[2aα,4β, 4aβ, 6β,9α-(αR*, βS*),11α,12α,12aα,12bα]]-β-(苯甲酰氨基)-α-羟基苯丙酸6,12b-双(乙酰氧基)-12-(苯甲酰氧基)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-十二氢-4,11-二羟基-4a,8,13,13-四甲基-5-氧代-7,11-亚甲基-1H-环癸并[3,4]苯并[1,2-b]氧杂丁环-9-基酯(紫杉醇)的合成\u003C\u002Fp>\u003Cp>在反应瓶中加入化合物7-三乙基硅烷巴卡亭Ⅲ1.0g(1.4mmol)和无水甲苯70ml, 搅拌溶解, 再在搅拌下加入N-苯甲酰-(2R,3S)-3-苯基异丝氨酸[N-benzoyl-(2R,3S)-3-phenylisoserine]1.3g(4.6mmol),再加入碳化双(环己基亚胺)DCC470mg(4.5mmol),搅拌反应5min,后加入二甲基氨基吡啶(DMAP)350mg(2.8mmol)搅拌4min, 加热至75ºC,搅拌反应10h.冷却至室温,用适量乙酸乙酯稀释,静置分层,分取有机层,依次用饱和NaHCO3水溶液洗3次,用水洗2次用饱和NaCl水溶液洗涤2次,然后用无水Na2SO4干燥,过滤,将滤液减压浓缩,剩余浓缩液经硅胶柱色谱纯化,得C-7保护的紫杉醇衍生物,将其溶于预先冷至0ºC的含0.5%盐酸的乙醇溶液62ml中,于0ºC下通N2保护搅拌30h(用TLC跟踪确认衍生物完全消失,反应即达终点,停止反应).反应液用乙酸乙酯450ml稀释,搅拌均匀后,用水洗涤,静置分层.分取有机层,再用水洗涤5次,用饱和NaCl水溶液洗涤2次,然后用无水Na2SO4干燥,过滤,将滤液减压浓缩,经硅胶[230~400目硅胶-60(Merck)]柱色谱纯化[洗脱剂:二氯甲烷\u002F甲醇(体积比90:10)],得含目的产物的洗脱液经后处理后的产物,再将其用含水甲醇结晶,得9..mg,收率89%,mp194~195 ºC.\u003C\u002Fp>\u003Cp>\u003C\u002Fp>","\u003Ctd>\n\r\n                                        \r\n                                        紫杉醇\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块1. 化学品\u003C\u002Fstrong>\n\u003Cbr \u002F> 产品名称：\n\u003Cb>Paclitaxel\u003C\u002Fb>\n\u003Cbr \u002F> 修改号码：\n\u003Cb>5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>GHS分类\u003C\u002Fb>\n\u003Cbr \u002F> 　物理性危害未分类\n\u003Cbr \u002F> 　健康危害\n\u003Cbr \u002F> 急性毒性（经口）\n\u003Cb>第4级\u003C\u002Fb>\n\u003Cbr \u002F> 急性毒性（经皮）\n\u003Cb>第4级\u003C\u002Fb>\n\u003Cbr \u002F> 急性毒性（吸入）\n\u003Cb>第4级\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>皮肤腐蚀\u002F刺激\u003C\u002Fb>\n\u003Cb>第2级\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>严重损伤\u002F刺激眼睛\u003C\u002Fb>\n\u003Cb>2A类\u003C\u002Fb>\n\u003Cbr \u002F> 呼吸敏感性\n\u003Cb>第1级\u003C\u002Fb>\n\u003Cbr \u002F> 皮肤敏感性\n\u003Cb>第1级\u003C\u002Fb>\n\u003Cbr \u002F> 生殖细胞敏感性\n\u003Cb>第2级\u003C\u002Fb>\n\u003Cbr \u002F> 生殖毒性\n\u003Cb>第2级\u003C\u002Fb>\n\u003Cbr \u002F> 　环境危害未分类\n\u003Cbr \u002F>\n\u003Cb>GHS标签元素\u003C\u002Fb>\n\u003Cbr \u002F> 　图标或危害标志\n\u003Cbr \u002F> 　信号词危险\n\u003Cbr \u002F> 　危险描述吸入或皮肤接触或吞咽有害。\n\u003Cbr \u002F> 造成皮肤刺激\n\u003Cbr \u002F> 造成严重眼刺激\n\u003Cbr \u002F> 吸入可能导致过敏或哮喘或呼吸困难\n\u003Cbr \u002F> 可能导致皮肤过敏性反应\n\u003Cbr \u002F> 怀疑会造成遗传缺陷\n\u003Cbr \u002F> 怀疑会损害生育能力或胎儿\n\u003Cbr \u002F> 　防范说明\n\u003Cbr \u002F> 紫杉醇\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>[预防]\u003C\u002Fb>使用前获取特定手册。\n\u003Cbr \u002F> 处理前必须阅读并理解所有安全措施。\n\u003Cbr \u002F> 避免吸入。\n\u003Cbr \u002F> 只能在室外或通风良好的环境下使用。\n\u003Cbr \u002F> 使用本产品时切勿吃东西，喝水或吸烟。\n\u003Cbr \u002F> 受污染的工作服不允许带出工作场所。\n\u003Cbr \u002F> 处理后要彻底清洗双手。\n\u003Cbr \u002F> 万一通风不够，佩戴防护面具。\n\u003Cbr \u002F>\n\u003Cb>穿戴防护手套\u002F护目镜\u002F防护面具。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>[急救措施]\u003C\u002Fb>吸入：将受害者移到新鲜空气处，在呼吸舒适的地方保持休息。若感不适，呼叫解毒\n\u003Cbr \u002F>\n\u003Cb>中心\u002F医生。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>食入：若感不适，呼叫解毒中心\u002F医生。漱口。\u003C\u002Fb>\n\u003Cbr \u002F> 眼睛接触：用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。继续冲洗。\n\u003Cbr \u002F>\n\u003Cb>眼睛接触：求医\u002F就诊\u003C\u002Fb>\n\u003Cbr \u002F> 皮肤接触：用大量肥皂和水轻轻洗。\n\u003Cbr \u002F>\n\u003Cb>若皮肤刺激或发生皮疹：求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 被污染的衣物清洗后方可重新使用。\n\u003Cbr \u002F>\n\u003Cb>如接触到或相关接触：求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>[储存]\u003C\u002Fb>存放处须加锁。\n\u003Cbr \u002F>\n\u003Cb>[废弃处置]\u003C\u002Fb>\n\u003Cb>根据当地政府规定把物品\u002F容器交与工业废弃处理机构。\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>单一物质\u002F混和物\u003C\u002Fb>单一物质\n\u003Cbr \u002F>\n\u003Cb>化学名(中文名)：\u003C\u002Fb>紫杉醇\n\u003Cbr \u002F> 百分比：\n\u003Cb>>98.0%(LC)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>CAS编码：\u003C\u002Fb>\n\u003Cb>33069-62-4\u003C\u002Fb>\n\u003Cbr \u002F> 分子式：\n\u003Cb>C47H51NO14\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 吸入：\n\u003Cb>将受害者移到新鲜空气处，保持呼吸通畅，休息。求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 皮肤接触：\n\u003Cb>立即去除\u002F脱掉所有被污染的衣物。用大量肥皂和水轻轻洗。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 眼睛接触：用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。\n\u003Cbr \u002F>\n\u003Cb>求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 食入：\n\u003Cb>求医\u002F就诊。漱口。\u003C\u002Fb>\n\u003Cbr \u002F> 紧急救助者的防护：救援者需要穿戴个人防护用品，比如橡胶手套和气密性护目镜。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块5. 消防措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 合适的灭火剂：干粉，泡沫，雾状水，二氧化碳\n\u003Cbr \u002F> 特殊危险性：小心，燃烧或高温下可能分解产生毒烟。\n\u003Cbr \u002F> 特定方法：从上风处灭火，根据周围环境选择合适的灭火方法。\n\u003Cbr \u002F> 非相关人员应该撤离至安全地方。\n\u003Cbr \u002F> 周围一旦着火：如果安全，移去可移动容器。\n\u003Cbr \u002F> 消防员的特殊防护用具：灭火时，一定要穿戴个人防护用品。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄漏应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F> 个人防护措施，防护用具，\n\u003Cb>使用特殊的个人防护用品（针对有毒颗粒的P3过滤式空气呼吸器）。远离溢出物\u002F泄露\u003C\u002Fb>\n\u003Cbr \u002F> 紧急措施：处并处在上风处。\n\u003Cbr \u002F> 泄露区应该用安全带等圈起来，控制非相关人员进入。\n\u003Cbr \u002F> 紫杉醇\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄漏应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F> 环保措施：防止进入下水道。\n\u003Cbr \u002F> 控制和清洗的方法和材料：清扫收集粉尘，封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的\n\u003Cbr \u002F> 法律法规处置。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块7. 操作处置与储存\u003C\u002Fstrong>\n\u003Cbr \u002F> 处理\n\u003Cbr \u002F> 技术措施：在通风良好处进行处理。穿戴合适的防护用具。防止粉尘扩散。处理后彻底清洗双手\n\u003Cbr \u002F> 和脸。\n\u003Cbr \u002F> 注意事项：如果可能，使用封闭系统。如果粉尘或浮质产生，使用局部排气。\n\u003Cbr \u002F> 操作处置注意事项：避免所有部位的接触！\n\u003Cbr \u002F> 贮存\n\u003Cbr \u002F> 储存条件：保持容器密闭。存放于凉爽、阴暗处。\n\u003Cbr \u002F> 存放处须加锁。\n\u003Cbr \u002F> 远离不相容的材料比如氧化剂存放。\n\u003Cbr \u002F> 包装材料：依据法律。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F> 工程控制：尽可能安装封闭体系或局部排风系统。同时安装淋浴器和洗眼器。\n\u003Cbr \u002F> 个人防护用品\n\u003Cbr \u002F> 　呼吸系统防护：\n\u003Cb>防尘面具，自携式呼吸器（SCBA），供气呼吸器等。使用通过政府标准的呼吸器。依\u003C\u002Fb>\n\u003Cbr \u002F> 据当地和政府法规。\n\u003Cbr \u002F> 　手部防护：防渗手套。\n\u003Cbr \u002F> 　眼睛防护：护目镜。如果情况需要，佩戴面具。\n\u003Cbr \u002F> 　皮肤和身体防护：防渗防护服。如果情况需要，穿戴防护靴。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F> 固体\n\u003Cbr \u002F>\n\u003Cb>外形（20°C）：\u003C\u002Fb>\n\u003Cbr \u002F> 外观：\n\u003Cb>晶体-粉末\u003C\u002Fb>\n\u003Cbr \u002F> 颜色：白色类白色\n\u003Cbr \u002F> 气味：无资料\n\u003Cbr \u002F>\n\u003Cb>pH:\u003C\u002Fb>无数据资料\n\u003Cbr \u002F> 熔点：\n\u003Cb>211°C (分解)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>沸点\u002F沸程\u003C\u002Fb>无资料\n\u003Cbr \u002F> 闪点：无资料\n\u003Cbr \u002F> 爆炸特性\n\u003Cbr \u002F> 　爆炸下限：无资料\n\u003Cbr \u002F> 　爆炸上限：无资料\n\u003Cbr \u002F> 密度：无资料\n\u003Cbr \u002F> 溶解度：\n\u003Cbr \u002F>\n\u003Cb>[水]\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>[其他溶剂]\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块10. 稳定性和反应性\u003C\u002Fstrong>\n\u003Cbr \u002F> 化学稳定性：一般情况下稳定。\n\u003Cbr \u002F> 危险反应的可能性：未报道特殊反应性。\n\u003Cbr \u002F> 须避免接触的物质氧化剂\n\u003Cbr \u002F>\n\u003Cb>危险的分解产物:\u003C\u002Fb>\n\u003Cb>一氧化碳, 二氧化碳, 氮氧化物 (NOx)\u003C\u002Fb>\n\u003Cbr \u002F> 紫杉醇\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块11. 毒理学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 急性毒性：\n\u003Cb>ipr-rat LD50:32530 ug\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>ivn-dog LDLo:15 mg\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F> 对皮肤腐蚀或刺激：无资料\n\u003Cbr \u002F> 对眼睛严重损害或刺激：无资料\n\u003Cbr \u002F> 生殖细胞变异原性：无资料\n\u003Cbr \u002F> 致癌性：\n\u003Cbr \u002F>\n\u003Cb>IARC =\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>NTP =\u003C\u002Fb>无资料\n\u003Cbr \u002F> 生殖毒性：无资料\n\u003Cbr \u002F>\n\u003Cb>RTECS 号码:\u003C\u002Fb>\n\u003Cb>DA8340700\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 生态毒性：\n\u003Cbr \u002F> 鱼类：无资料\n\u003Cbr \u002F> 甲壳类：无资料\n\u003Cbr \u002F> 藻类：无资料\n\u003Cbr \u002F>\n\u003Cb>残留性 \u002F 降解性：\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>潜在生物累积 （BCF):\u003C\u002Fb>无资料\n\u003Cbr \u002F> 土壤中移动性\n\u003Cbr \u002F>\n\u003Cb>　log水分配系数：\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>　土壤吸收系数 （Koc）：\u003C\u002Fb>无资料\n\u003Cbr \u002F> 　亨利定律无资料\n\u003Cbr \u002F>\n\u003Cb>constant(PaM3\u002Fmol):\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块13. 废弃处置\u003C\u002Fstrong>\n\u003Cbr \u002F> 如果可能，回收处理。请咨询当地管理部门。建议在可燃溶剂中溶解混合，在装有后燃和洗涤装置的化学焚烧炉中\n\u003Cbr \u002F> 焚烧。废弃处置时请遵守国家、地区和当地的所有法规。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块14. 运输信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 联合国分类：与联合国分类标准不一致\n\u003Cbr \u002F>\n\u003Cb>UN编号：\u003C\u002Fb>未列明\n\u003Cbr \u002F>\n\n\u003Cstrong>模块15. 法规信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>《危险化学品安全管理条例》（2002年1月26日国务院发布，2011年2月16日修订）: 针对危险化学品的安全使用、\u003C\u002Fb>\n\u003Cbr \u002F> 生产、储存、运输、装卸等方面均作了相应的规定。\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\u003Cbr \u002F>\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[384,390,396,402,408,414,420,426,432,438,444,450],{"slug":385,"cid":386,"name":387,"nameZh":388,"cas":389},"785883051849682944","J-6804-2","Naphthol Green B","萘酚绿B","19381-50-1",{"slug":391,"cid":392,"name":393,"nameZh":394,"cas":395},"785894254722420736","J-1501686-1","Bis(tetrabutylammonium) bis(maleonitriledithiolato)nickel(II) complex","双(四丁铵)合双(顺丁烯腈二硫醇)镍(II)","18958-57-1",{"slug":397,"cid":398,"name":399,"nameZh":400,"cas":401},"785891962094882816","J-31658-5","Methylthymol Blue","甲基百里香酚蓝","1945-77-3",{"slug":403,"cid":404,"name":405,"nameZh":406,"cas":407},"785882573246042112","J-1109645-0","Xylenol orange tetrasodium salt","二甲酚橙四钠盐","3618-43-7",{"slug":409,"cid":410,"name":411,"nameZh":412,"cas":413},"785891276762386432","J-1396124-5","calcium 2-[[(2-aminoethyl)amino]methyl]-4-dodecylphenolate (1:2)","2-[[2-氨基乙基]氨甲基]-4-十二烷基苯酚钙盐","68516-56-3",{"slug":415,"cid":416,"name":417,"nameZh":418,"cas":419},"785884039641829376","J-22660-8","Bromocresol green sodium salt","溴甲酚绿钠","62625-32-5",{"slug":421,"cid":422,"name":423,"nameZh":424,"cas":425},"785893699610480640","J-1967655-2","Bromocresol Green","溴甲酚绿","76-60-8",{"slug":427,"cid":428,"name":429,"nameZh":430,"cas":431},"785884185813323776","J-23029-5","Bromophenol blue sodium salt","溴酚蓝钠盐","34725-61-6",{"slug":433,"cid":434,"name":435,"nameZh":436,"cas":437},"785876273212690432","J-1097747-6","Xylenol Orange","二甲酚橙","1611-35-4",{"slug":439,"cid":440,"name":441,"nameZh":442,"cas":443},"785882477062262784","J-4286-4","Bromophenol Blue","溴酚蓝","115-39-9",{"slug":445,"cid":446,"name":447,"nameZh":448,"cas":449},"785891769618272256","J-1960005-6","bibrocathol","铋溴酚","6915-57-7",{"slug":451,"cid":452,"name":453,"nameZh":454,"cas":455},"785895669939310592","J-1380192-8","Bromothymol Blue sodium salt","溴百里酚蓝钠盐","34722-90-2",1794251394681,"zh-CN",[]]