[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1918-9":171,"verified-suppliers-J-1918-9":281},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":186,"ghs":209,"offers":210,"activity":211,"upstream":236,"downstream":237,"customs":238,"safetyRows":239,"updatedAt":240,"isProhibited":241,"related":242,"__ts":279,"__lang":280,"__slug":173},"785894446305644544","J-1918-9","\u002Fimages\u002Fchem_structures_svg\u002F220\u002F249921-19-5.svg","阿拉莫林","249921-19-5","C31H42N6O3","546.704","organic","有机化合物","Organic Compounds",[],[184,185],"安那莫林","(3R)-1-(2-甲基丙氨酰-D-色氨酰)-3-苯甲基-3-哌啶1,2,2-三甲基甲酰肼",[187,191,195,198,201,205],{"label":188,"labelZh":188,"value":189,"prop":190},"Density","1.2±0.1 g\u002Fcm3","density",{"label":192,"labelZh":193,"value":194},"Exact Mass","精确质量","546.331848",{"label":196,"labelZh":196,"value":197},"PSA","114.77000",{"label":199,"labelZh":199,"value":200},"LogP","2.98",{"label":202,"labelZh":203,"value":204},"Refractive Index","折射率","1.619",{"label":206,"labelZh":207,"value":208},"Storage Conditions","储存条件","-20°C",null,[],[212,215,218,221,224,227,230,233],{"key":213,"value":214},"描述","Anamorelin 是一种新型 ghrelin receptor 激动剂,FLIPR 检测中,EC50 为 0.74 nM。",{"key":216,"value":217},"相关类别","信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\nGHSR\n研究领域\n>>\n癌症",{"key":219,"value":220},"靶点","Ki: 0.7 nM (ghrelin receptor)[1] EC50: 0.74 nM (ghrelin receptor)[1]",{"key":222,"value":223},"体外研究","在FLIPR测定中,Anamorelin(ANAM)对生长素释放肽受体显示出显着的激动剂活性,EC50值为0.74nM。 Anamorelin在浓度高达1,000 nM时未观察到明显的拮抗活性。在结合实验中,Anamorelin与生长素释放肽受体结合,结合亲和常数(Ki)为0.70nM。在用放射性标记的ibutamoren(35S-MK-677;另一种生长素释放肽受体激动剂)的竞争测定中,还发现Anamorelin(ANAM)以高亲和力结合生长素释放肽受体(IC50 = 0.69nM)。在与Anamorelin孵育的大鼠垂体细胞中,对GH释放具有剂量依赖性刺激作用,并且效力(EC 50)为1.5nM。筛选Anamorelin对一组超过100种受体,离子通道,转运蛋白和酶的活性。阿那瑞林表现出与速激肽神经激肽2(NK2)位点的结合(IC50 =0.021μM);然而,随后的NK2功能测定证明没有功能活性[1]。",{"key":225,"value":226},"体内研究","在大鼠中,与载体对照相比,口服剂量为3,10或30mg\u002Fkg的Anamorelin(ANAM)每天一次显着增加食物摄取和体重,从治疗的第2天到第7天。食物摄入和体重增加的累积变化剂量依赖性地增加,并且与对照相比,这些变化在所有剂量水平上都是显着的(P \u003C0.05)。以3,10或30mg\u002Fkg的单次口服剂量给予阿那瑞林诱导大鼠血浆GH水平和GH AUC0-6h的剂量依赖性增加[1]。",{"key":228,"value":229},"激酶实验","对于竞争测定，将Anamorelin（ANAM）浓度（1pM-10μM）与35S-MK-677一起加入膜中。通过添加10μM未标记的MK-677来确定非特异性结合。将混合物在30℃下温育60分钟，然后将样品施加到GF \u002F B过滤器上，该过滤器已经用0.5％PEI预处理60分钟。随后将滤膜在0.9％NaCl中洗涤并使用OptiPhase计数器[1]计数。",{"key":231,"value":232},"动物实验","大鼠[1]为了评估食物摄入量和体重，将大鼠分为四组：阿诺瑞林3 mg \u002F kg（n = 7），10 mg \u002F kg（n = 7）或30 mg \u002F kg（n = 7），或载体对照（n = 8），并且在单次给药之前和0.25,0.5,1,2,3,4,5和6小时之前收集100μL血液样品。用戊巴比妥钠64.8mg \u002F kg麻醉大鼠。将填充有肝素化盐水溶液的导管插入左股动脉中用于血液收集，并装配有延长管，1mL取样注射器和三通旋塞以允许多余的血液返回。使用大鼠生长激素EIA试剂盒和酶标仪免疫化学测量血浆GH水平。测量一式两份进行。给药后0至6小时（AUC0-6h）的GH浓度曲线下的面积和GH血浆浓度的时间过程进行评估。猪[1]在猪（每组n = 6）中，通过剂量导管将阿那瑞林直接给药至胃腔。在给药前30和15分钟以及给药后0,5,15,30,45,60和120分钟收集血液样品用于GH的刺激特征。动物接受单剂量（3.5mg \u002F kg）或每日一次给药（1mg \u002F kg）7天，并在第一次和第七次阿那瑞林后服用刺激曲线。为了评估IGF-1水平，猪接受安慰剂或阿拉莫林7天（1mg \u002F kg \u002F天），并且接下来的7天两次治疗被交叉。在给药前每天一次采集一次血样。",{"key":234,"value":235},"参考文献","[1].\nPietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5(4):329-37.",[],[],[],[],"2026-08-21T07:51:12.859463Z",false,[243,249,255,261,267,273],{"slug":244,"cid":245,"name":246,"nameZh":247,"cas":248},"785896219460243456","J-1338606-7","Aluminum phthalocyanine cation","铝酞菁","47822-79-7",{"slug":250,"cid":251,"name":252,"nameZh":253,"cas":254},"785876270784188416","J-1099566-6","3-[(2,4-dinitrophenyl)diazenyl]-4-hydroxy-2,7-naphthalenedisulfonic acid disodium salt","硝氮黄","5423-07-4",{"slug":256,"cid":257,"name":258,"nameZh":259,"cas":260},"785884624998895616","J-1347917-2","Mancozeb","代森锰锌","2234-56-2",{"slug":262,"cid":263,"name":264,"nameZh":265,"cas":266},"785875782072274944","J-10935-8","Sodium ionophore III","钠离子载体 III","81686-22-8",{"slug":268,"cid":269,"name":270,"nameZh":271,"cas":272},"785929817445896192","J-494462-9","Etioporphyrin copper","初叶卟啉铜","54816-20-5",{"slug":274,"cid":275,"name":276,"nameZh":277,"cas":278},"785894492237467648","J-1310235-5","Mancopper","代森锰铜","53988-93-5",1792618564350,"zh-CN",[]]