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10x）的时间。对于小鼠中的药效标记物分析，在尸检时收集肿瘤和邻近皮肤，在10％福尔马林中固定过夜，并在70％乙醇中洗涤\u002F储存。对于皮肤穿孔活组织检查，刮削约4平方英寸的面积。使用吸入的异氟烷麻醉大鼠，并使用利多卡因的皮下给药局部麻醉狗。使用4mm活检穿孔器收集样品。将皮肤打孔器在10％福尔马林中固定过夜，然后在70％乙醇中洗涤\u002F储存。",{"key":241,"value":242},"参考文献","[1].\nMontano R, et al. Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites. Mol Cancer Ther. 2012 Feb;11(2):427-38.\n[2].\nGuzi TJ, et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. 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