[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"compound-J-18844-5":8,"verified-suppliers-J-18844-5":216,"$fyk2oeqxpb7bd":217},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.689327,"live",{"slug":9,"cid":10,"imgSvg":11,"name":12,"nameZh":12,"cas":13,"formula":14,"iupac":12,"mdl":15,"mw":16,"category":17,"categoryName":18,"categoryEnName":19,"industry":15,"tags":20,"synonyms":21,"properties":23,"ghs":87,"offers":88,"activity":89,"upstream":111,"downstream":136,"customs":143,"safetyRows":156,"toxicity":173,"synthesis":174,"updatedAt":175,"isProhibited":176,"related":177,"__ts":214,"__lang":215,"__slug":10},"785881330146611200","J-18844-5","\u002Fimages\u002Fchem_structures_svg\u002F112\u002F518-17-2.svg","吴茱萸碱","518-17-2","C19H17N3O","","303.358","bases","有机碱","Organic Bases",[],[22],"吴茱萸胺",[24,29,34,39,44,48,52,55,59,63,67,71,75,79,83],{"label":25,"labelZh":26,"value":27,"prop":28},"Melting Point","熔点","263 - 265ºC","meltingPoint",{"label":30,"labelZh":31,"value":32,"prop":33},"Boiling Point","沸点","575.1±50.0 °C at 760 mmHg","boilingPoint",{"label":35,"labelZh":36,"value":37,"prop":38},"Density","密度","1.4±0.1 g\u002Fcm3","density",{"label":40,"labelZh":41,"value":42,"prop":43},"Flash Point","闪点","301.6±30.1 °C","flashPoint",{"label":45,"labelZh":46,"value":47},"Exact Mass","精确质量","303.137177",{"label":49,"labelZh":50,"value":51},"PSA","其他信息","39.34000",{"label":53,"labelZh":53,"value":54},"LogP","1.64",{"label":56,"labelZh":57,"value":58},"Appearance","外观性状","细粉末颜色",{"label":60,"labelZh":61,"value":62},"Vapor Pressure","蒸汽压","0.0±1.6 mmHg at 25°C",{"label":64,"labelZh":65,"value":66},"Refractive Index","折射率","1.764",{"label":68,"labelZh":69,"value":70},"Storage Conditions","储存条件","储存于阴凉、干燥、通风良好的库房。远离火种、热源。防止阳光直射。包装密封。应与酸类、食用化学品分开存放，切忌混储。储区应备有合适的材料收容泄漏物。",{"label":72,"labelZh":73,"value":74},"Stability","稳定性","按规格使用和贮存，不会发生分解，避免与氧化物接触",{"label":76,"labelZh":77,"value":78},"Molecular Structure","分子结构","1、 摩尔折射率：89.85\n2、 摩尔体积（m\n3\n\u002Fmol）：217.4\n3、 等张比容（90.2K）：637.2\n4、 表面张力（dyne\u002Fcm）：73.8\n5、 极化率（10\n-24\ncm\n3\n）：35.62",{"label":80,"labelZh":81,"value":82},"Computational Chemistry","计算化学","1、 疏水参数计算参考值（XlogP）：3.1\n2、 氢键供体数量：1\n3、 氢键受体数量：2\n4、 可旋转化学键数量：0\n5、 互变异构体数量：\n6、 拓扑分子极性表面积（TPSA）：39.3\n7、 重原子数量：23\n8、 表面电荷：0\n9、 复杂度：495\n10、 同位素原子数量：0\n11、 确定原子立构中心数量：1\n12、 不确定原子立构中心数量：0\n13、 确定化学键立构中心数量：0\n14、 不确定化学键立构中心数量：0\n15、 共价键单元数量：1",{"label":84,"labelZh":85,"value":86},"Additional Property","更多","1. 性状：黄色片状结晶\n2. 密度（g\u002F cm\n3\n,25\u002F4℃）：未确定\n3. 相对蒸汽密度（g\u002Fcm\n3\n,空气=1）：未确定\n4. 熔点（ºC）：278\n5. 沸点（ºC,常压）：78-80\n6. 沸点（ºC,8kPa）：未确定\n7. 折射率：未确定\n8. 闪点（ºC）：未确定\n9. 比旋光度（º）：未确定\n10. 自燃点或引燃温度（ºC）：未确定\n11. 蒸气压（kPa,25ºC）：未确定\n12. 饱和蒸气压（kPa,60ºC）：未确定\n13. 燃烧热（KJ\u002Fmol）：未确定\n14. 临界温度（ºC）：未确定\n15. 临界压力（KPa）：未确定\n16. 油水（辛醇\u002F水）分配系数的对数值：未确定\n17. 爆炸上限（%,V\u002FV）：未确定\n18. 爆炸下限（%,V\u002FV）：未确定\n19. 溶解性：几乎不溶于水",null,[],[90,93,96,99,102,105,108],{"key":91,"value":92},"描述","Evodiamine是从萱草的果实中分离的生物碱, 具有多种生物活性,比如抗炎,抗肥胖和抗肿瘤。",{"key":94,"value":95},"相关类别","信号通路\n>>\n其他\n>>\n其他\n研究领域\n>>\n癌症\n天然产物\n>>\n生物碱",{"key":97,"value":98},"体外研究","吴茱萸碱通过诱导细胞凋亡显示出对多种人癌细胞系的细胞毒性。此外,它是一种天然的多靶点抗肿瘤分子,通过各种分子机制发挥抗肿瘤活性,如caspase依赖和非依赖性途径,鞘磷脂途径,钙\u002F JNK信号,31 PI3K\u002FAkt\u002Fcaspase和Fas-L\u002FNF-κB信号通路32 [1]。",{"key":100,"value":101},"体内研究","吴茱萸碱抑制达泊西汀的代谢。与对照组相比,吴茱萸碱组中达泊西汀的t1\u002F2,AUC(0-∞)和Tmax的药代动力学参数分别显着增加63.3％,44.8％和50.4％。此外,吴茱萸碱显着降低了去甲基度帕西汀的t1\u002F2和AUC(0-∞)的药代动力学参数[2]。吴茱萸碱抑制皮下H22异种移植模型中的肿瘤生长。吴茱萸碱在体内减弱VEGF诱导的血管生成[3]。",{"key":103,"value":104},"细胞实验","将吴茱萸碱溶解在DMSO中并在使用前用适当的培养基稀释。使用MTT测定法测定吴茱萸碱启动的新支架对人癌细胞系A549（肺癌），MDA-MB-435（乳腺癌）和HCT116（结肠癌）的生长抑制活性。吴茱萸碱和camptithecin用作参考药物[1]。",{"key":106,"value":107},"动物实验","大鼠：将12只健康雄性Sprague-Dawley大鼠随机分成2组：对照组（单独口服10mg \u002F kg达泊西汀）和联合用药组（10mg \u002F kg达泊西汀口服共同给予100mg \u002F kg吴茱萸碱） 。通过超高效液相色谱 - 串联质谱（UPLC-MS \u002F MS）估算达泊西汀和去甲基度帕西汀的血浆浓度，并计算不同的药代动力学参数[2]。小鼠：通过使用4-6周龄雄性BALB \u002F c裸鼠建立裸鼠异种移植模型。每天给小鼠腹腔注射20mg \u002F kg（10mL \u002F kg）的吴茱萸碱，每周两次给6只小鼠腹膜内注射10mg \u002F kg的5-氟尿嘧啶（5-FU），并且不处理6只小鼠。通过测量两个维度来确定肿瘤体积，肿瘤体积=长度×宽度×宽度\u002F 2。治疗2或3周后，在用麻醉麻醉下通过颈脱位处死小鼠，并收集肿瘤组织[3]。",{"key":109,"value":110},"参考文献","[1].\nWang S, et al. Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents. J Med Chem. 2015 Aug 27;58(16):6678-96.\n[2].\nLi RF,et al. Effects of Evodiamine on the Pharmacokinetics of Dapoxetine and Its Metabolite Desmethyl Dapoxetine inRats. Pharmacology. 2016;97(1-2):43-7.\n[3].\nShi L, et al. Evodiamine exerts anti-tumor effects against hepatocellular carcinoma through inhibiting β-catenin-mediated angiogenesis. Tumour Biol. 2016 Sep;37(9):12791-12803.",[112,118,124,130],{"slug":113,"cid":114,"name":115,"nameZh":115,"cas":116,"imgSvg":117},"785875578048745500","J-1033882-5","4,9-二氢-3H-吡啶并(3...","4894-26-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F339\u002F4894-26-2.svg",{"slug":119,"cid":120,"name":121,"nameZh":121,"cas":122,"imgSvg":123},"785875559006605300","J-10440-9","N-甲基靛红酸酐","10328-92-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F487\u002F10328-92-4.svg",{"slug":125,"cid":126,"name":127,"nameZh":127,"cas":128,"imgSvg":129},"785892566783496200","J-961853-2","色胺","61-54-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F201\u002F61-54-1.svg",{"slug":131,"cid":132,"name":133,"nameZh":133,"cas":134,"imgSvg":135},"785896946811277300","J-45842-3","靛红酸酐","118-48-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F205\u002F118-48-9.svg",[137],{"slug":138,"cid":139,"name":140,"nameZh":140,"cas":141,"imgSvg":142},"785896794750980100","J-45381-1","2-(甲氨基)苯甲酸","119-68-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F435\u002F119-68-6.svg",[144,147,150,153],{"key":145,"value":146},"海关编码","2933990090",{"key":148,"value":149},"中文概述","2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":151,"value":152},"申报要素","品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期",{"key":154,"value":155},"Summary","2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[157,160,163,166,169,172],{"key":158,"value":159},"危害码 (欧洲)","T",{"key":161,"value":162},"风险声明 (欧洲)","R25",{"key":164,"value":165},"安全声明 (欧洲)","S45",{"key":167,"value":168},"危险品运输编码","UN 2811 6.1\u002FPG 3",{"key":170,"value":171},"危险类别","6.1",{"key":145,"value":146},"\u003Ctd>\n\n\u003Cp>\u003Cstrong>吴茱萸碱生态学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp>该物质对环境可能有危害，对水体应给予特别注意。  \u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F518-17-2_314535.html#duXinDiv\">吴茱萸碱毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Cp>已生物合成。植物来源为芸香科植物吴茱萸及同属植物石虎的果实。  \u003C\u002Fp>","2026-08-21T07:51:12.859463Z",false,[178,184,190,196,202,208],{"slug":179,"cid":180,"name":181,"nameZh":182,"cas":183},"785889061310042112","J-1358812-8","Sodium bis(trifluoromethanesulfonyl)imide","双(三氟甲基磺酰基)亚胺钠","91742-21-1",{"slug":185,"cid":186,"name":187,"nameZh":188,"cas":189},"785881499567132672","J-19714-2","Auramine O","金胺O","2465-27-2",{"slug":191,"cid":192,"name":193,"nameZh":194,"cas":195},"785889828079144960","J-1377145-8","Pararosaniline","副品红碱","25620-78-4",{"slug":197,"cid":198,"name":199,"nameZh":200,"cas":201},"785894706218274816","J-1104857-6","N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine","月桂胺二亚丙基二胺","2372-82-9",{"slug":203,"cid":204,"name":205,"nameZh":206,"cas":207},"785882613301645312","J-5033-1","Bis(ethylenediamine)palladium(II) dichloride","双(乙二胺)氯化钯(II)","16483-18-4",{"slug":209,"cid":210,"name":211,"nameZh":212,"cas":213},"785880540673740800","J-938363-2","3,3'-Dimethyl-[1,1'-binaphthalene]-4,4'-diamine","3,3'-二甲基-[1,1'-联萘]-4,4'-二胺","13138-48-2",1792654984225,"zh-CN",[],{"rows":218,"total":378,"current":5,"size":353},[219,241,253,268,282,293,304,321,331,343,354,366],{"slug":220,"cid":221,"imgSvg":222,"name":223,"nameZh":224,"cas":225,"formula":226,"iupac":223,"category":227,"categoryName":228,"categoryEnName":229,"industry":15,"tags":230,"offersCount":232,"supplierCount":233,"bestOffer":234},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids",[231],"In Stock",4,2,{"unitPrice":235,"pack":236,"currency":237,"origin":238,"originFlag":239,"moq":15,"stock":240},2.64,"500g","CNY","China","CN","in-stock",{"slug":242,"cid":243,"imgSvg":244,"name":245,"nameZh":246,"cas":247,"formula":248,"iupac":245,"category":227,"categoryName":228,"categoryEnName":229,"industry":15,"tags":249,"offersCount":232,"supplierCount":5,"bestOffer":250},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[231],{"unitPrice":251,"pack":252,"currency":237,"origin":238,"originFlag":239,"moq":15,"stock":240},180,"5g",{"slug":254,"cid":255,"imgSvg":256,"name":257,"nameZh":258,"cas":259,"formula":260,"iupac":257,"category":261,"categoryName":262,"categoryEnName":263,"industry":15,"tags":264,"offersCount":265,"supplierCount":233,"bestOffer":266},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[231],7,{"unitPrice":267,"pack":236,"currency":237,"origin":238,"originFlag":239,"moq":15,"stock":240},24,{"slug":269,"cid":270,"imgSvg":271,"name":272,"nameZh":273,"cas":274,"formula":275,"iupac":272,"category":227,"categoryName":228,"categoryEnName":229,"industry":15,"tags":276,"offersCount":277,"supplierCount":233,"bestOffer":278},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[231],5,{"unitPrice":279,"pack":280,"currency":237,"origin":281,"originFlag":239,"moq":15,"stock":240},6,"1000g","中国",{"slug":283,"cid":284,"imgSvg":285,"name":286,"nameZh":287,"cas":288,"formula":289,"iupac":286,"category":227,"categoryName":228,"categoryEnName":229,"industry":15,"tags":290,"offersCount":233,"supplierCount":233,"bestOffer":291},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[231],{"unitPrice":292,"pack":236,"currency":237,"origin":238,"originFlag":239,"moq":15,"stock":240},3.78,{"slug":294,"cid":295,"imgSvg":296,"name":297,"nameZh":298,"cas":299,"formula":300,"iupac":297,"category":261,"categoryName":262,"categoryEnName":263,"industry":15,"tags":301,"offersCount":265,"supplierCount":302,"bestOffer":303},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[231],3,{"unitPrice":302,"pack":236,"currency":237,"origin":281,"originFlag":239,"moq":15,"stock":240},{"slug":305,"cid":306,"imgSvg":307,"name":308,"nameZh":309,"cas":310,"formula":311,"iupac":308,"category":312,"categoryName":313,"categoryEnName":314,"industry":15,"tags":315,"offersCount":316,"supplierCount":316,"bestOffer":317},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":318,"pack":15,"currency":319,"origin":15,"originFlag":15,"moq":15,"stock":320},9007199254740991,"USD","made-to-order",{"slug":322,"cid":323,"imgSvg":324,"name":325,"nameZh":326,"cas":327,"formula":328,"iupac":325,"category":261,"categoryName":262,"categoryEnName":263,"industry":15,"tags":329,"offersCount":277,"supplierCount":233,"bestOffer":330},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[231],{"unitPrice":279,"pack":236,"currency":237,"origin":238,"originFlag":239,"moq":15,"stock":240},{"slug":332,"cid":333,"imgSvg":334,"name":335,"nameZh":336,"cas":337,"formula":338,"iupac":335,"category":261,"categoryName":262,"categoryEnName":263,"industry":15,"tags":339,"offersCount":232,"supplierCount":233,"bestOffer":340},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[231],{"unitPrice":341,"pack":342,"currency":237,"origin":238,"originFlag":239,"moq":15,"stock":240},112.8,"100g",{"slug":344,"cid":345,"imgSvg":346,"name":347,"nameZh":348,"cas":349,"formula":350,"iupac":347,"category":261,"categoryName":262,"categoryEnName":263,"industry":15,"tags":351,"offersCount":265,"supplierCount":5,"bestOffer":352},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[231],{"unitPrice":353,"pack":342,"currency":237,"origin":238,"originFlag":239,"moq":15,"stock":240},12,{"slug":355,"cid":356,"imgSvg":357,"name":358,"nameZh":359,"cas":360,"formula":361,"iupac":358,"category":261,"categoryName":262,"categoryEnName":263,"industry":15,"tags":362,"offersCount":363,"supplierCount":302,"bestOffer":364},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[231],10,{"unitPrice":365,"pack":236,"currency":237,"origin":15,"originFlag":15,"moq":15,"stock":240},2.6,{"slug":367,"cid":368,"imgSvg":369,"name":370,"nameZh":371,"cas":372,"formula":373,"iupac":370,"category":261,"categoryName":262,"categoryEnName":263,"industry":15,"tags":374,"offersCount":233,"supplierCount":5,"bestOffer":376},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[375],"Made to Order",{"unitPrice":377,"pack":236,"currency":237,"origin":238,"originFlag":239,"moq":15,"stock":240},5.6,3204]