[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1860-5":171,"verified-suppliers-J-1860-5":302},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.689327,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":186,"ghs":215,"offers":216,"activity":217,"upstream":239,"downstream":258,"customs":259,"safetyRows":260,"updatedAt":261,"isProhibited":262,"related":263,"__ts":300,"__lang":301,"__slug":173},"785894424008724480","J-1860-5","\u002Fimages\u002Fchem_structures_svg\u002F092\u002F1350514-68-9.svg","格佐匹韦","1350514-68-9","C38H50N6O9S","766.903","organic","有机化合物","Organic Compounds",[],[184,185],"格拉瑞韦","格佐普韦",[187,192,196,200,203,207,211],{"label":188,"labelZh":189,"value":190,"prop":191},"Density","密度","1.4±0.1 g\u002Fcm3","density",{"label":193,"labelZh":194,"value":195},"Exact Mass","精确质量","766.335999",{"label":197,"labelZh":198,"value":199},"PSA","其他信息","203.60000",{"label":201,"labelZh":201,"value":202},"LogP","3.93",{"label":204,"labelZh":205,"value":206},"Appearance","外观性状","粉末",{"label":208,"labelZh":209,"value":210},"Refractive Index","折射率","1.633",{"label":212,"labelZh":213,"value":214},"Storage Conditions","储存条件","-20℃",null,[],[218,221,224,227,230,233,236],{"key":219,"value":220},"描述","Grazoprevir (MK-5172) 是选择性的丙型肝炎病毒 NS3\u002F4a蛋白酶抑制剂,作用于 gt1b,gt1a,gt2a,gt2b 和 gt3a的 Ki 分别为 0.01 nM,0.01 nM,0.08 nM,0.15 nM 和 0.90 nM。",{"key":222,"value":223},"相关类别","信号通路\n>>\n代谢酶\u002F蛋白酶\n>>\nHCV蛋白酶\n信号通路\n>>\n抗感染\n>>\nHCV\n研究领域\n>>\n感染",{"key":225,"value":226},"靶点","Ki: 0.01±\u003C0.01 nM (gt1b), 0.01±0.01 nM (gt1a), 0.08±0.02 nM (gt2a), 0.15±0.06 nM (gt2b), 0.90±0.2 nM (gt3a)[1]",{"key":228,"value":229},"体外研究","在生物化学分析中,Grazoprevir(MK-5172)对一组主要基因型和具有常见抗性突变的变体有效,Ki为0.01±\u003C0.01 nM(gt1b),0.01±0.01 nM(gt1a),0.08±0.02 nM (gt2a),0.15±0.06nM(gt2b),0.90±0.2nM(gt3a),0.07±0.01nM(gt1bR155K),0.14±0.03nM(gt1bD168V),0.30±0.04nM(gt1bD168Y),5.3±0.9nM(gt1bA156T)分别为12±2nM(gt1bA156V)。在复制子测定中,Grazoprevir显示针对基因型1a,1b和2a的亚纳摩尔至低纳摩尔EC50,对于gt1bcon1,gt1a和gt2a,EC50分别为0.5±0.1nM,2±1nM和2±1nM。 Grazoprevir对一组HCV复制突变体NS5A(Y93H)(EC50 = 0.7±0.3 nM),NS5B核苷(S282T)(EC50 = 0.3±0.1 nM)和NS5B(C316Y)(EC50 = 0.4±0.2)有效[ 1]。 Grazoprevir(MK-5172)保持对gt 3a酶以及广泛的突变酶组的优异效力,在复制子系统中具有优异的效力[gt1b IC50(50％NHS)= 7.4nM; gtaa IC50(40％NHS)= 7 nM],显示出优异的大鼠肝脏暴露[2]。",{"key":231,"value":232},"体内研究","Grazoprevir(MK-5172)在体内对慢性HCV感染的黑猩猩有效[1]。当给予狗时,Grazoprevir(MK-5172)显示静脉给药后5 mL\u002Fmin\u002Fkg的低清除率和3 h的半衰期,并且在1 mg\u002Fkg口服后具有良好的血浆暴露(AUC =0.4μMh)剂量。狗肝脏活检研究表明,1 mg\u002Fkg口服剂量后Grazoprevir的肝脏浓度在24 h时间点为1.4μM。与其在大鼠中的行为类似,Grazoprevir证明有效分配到肝脏组织中,并且相对于效力,在狗口服给药后24小时维持高肝脏浓度[2]。",{"key":234,"value":235},"动物实验","大鼠和狗[1]在大鼠和狗中进行研究。对于格拉霉素静脉内给予大鼠或狗的研究，将化合物配制在聚乙二醇200（PEG200）中，并以2mg \u002F kg体重（大鼠）或0.5mg \u002F kg（狗）的推注给药。对于口服研究，化合物的结晶钾盐以5mg \u002F kg（大鼠）或1mg \u002F kg（狗）的PEG400溶液给药。对于所有研究，在适当的时间将血液样品收集在含EDTA的管中，并通过离心分离血浆并储存在-70℃直至分析。 Grazoprevir（MK-5172）水平的定量通过蛋白质沉淀后的高效液相色谱\u002F质谱（LC \u002F MS \u002F MS）进行。在实验结束时从大鼠研究中获得肝样品。对于狗，在镇静后收集肝脏活组织检查样品（20μL）。将组织样品在四体积的去离子水中匀浆，并在蛋白质沉淀后通过LC \u002F MS \u002F MS测定药物浓度。",{"key":237,"value":238},"参考文献","[1].\nSumma V, et al. MK-5172, a selective inhibitor of hepatitis C virus NS3\u002F4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7.\n[2].\nHarper S, et al. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3\u002F4a Protease Inhibitor. ACS Med Chem Lett. 2012 Mar 2;3(4):332-6.",[240,246,252],{"slug":241,"cid":242,"name":243,"nameZh":243,"cas":244,"imgSvg":245},"785880482146422800","J-1106862-4","3,4-二氨基苯甲醚盐酸盐","59548-39-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F206\u002F59548-39-9.svg",{"slug":247,"cid":248,"name":249,"nameZh":249,"cas":250,"imgSvg":251},"785881423000113200","J-19315-9","L-叔亮氨酸甲酯盐酸盐","63038-27-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F408\u002F63038-27-7.svg",{"slug":253,"cid":254,"name":255,"nameZh":255,"cas":256,"imgSvg":257},"785872818242850800","J-980813-9","2,3-二羟基-6-甲氧基喹喔啉","31910-18-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F483\u002F31910-18-6.svg",[],[],[],"2026-08-21T07:51:12.859463Z",false,[264,270,276,282,288,294],{"slug":265,"cid":266,"name":267,"nameZh":268,"cas":269},"785883889598992384","J-41096-0","Ponceau S","丽春红S","6226-79-5",{"slug":271,"cid":272,"name":273,"nameZh":274,"cas":275},"785891538658922496","J-1414589-2","(Tetracarboxyphthalocyaninato)copper(II)","四羧基酞菁铜","16337-64-7",{"slug":277,"cid":278,"name":279,"nameZh":280,"cas":281},"785898552906747904","J-51396-4","(Tetracarboxyphthalocyaninato)cobalt(II)","四羧基酞菁钴","25511-95-9",{"slug":283,"cid":284,"name":285,"nameZh":286,"cas":287},"785898501409083392","J-1373543-6","(Tetracarboxyphthalocyaninato)nickel(II)","四羧基酞菁镍","107122-90-7",{"slug":289,"cid":290,"name":291,"nameZh":292,"cas":293},"785891727809449984","J-30923-7","Beryllon II","铍试剂II","51550-25-5",{"slug":295,"cid":296,"name":297,"nameZh":298,"cas":299},"785895072792055808","J-40041-9","(Tetra-t-butylphthalocyaninato)cobalt(II)","四叔丁基酞菁钴","129551-41-3",1792677356941,"zh-CN",[]]