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[1]分析数据。",{"key":268,"value":269},"细胞实验","HL-60，NB4，U937，KG-1和K562细胞常规传代于RPMI-1640中，补充有10％热灭活的FBS，2 mM L-谷氨酰胺，50 U \u002F mL青霉素和50μg\u002F mL链霉素。在37°C下，5％CO2加湿的气氛。对于实验，通过离心收获指数生长的细胞，并重悬于含有10％FBS的新鲜培养基中。在各种浓度的DMSO或1μMATRA存在下，在BD Falcon六孔板中以2×10 5 \u002F mL的初始细胞密度接种细胞。在分化剂之前20分钟加入雷帕霉素（20nM）。在第2天，向每个孔中加入0.3mL新鲜培养基。通过台盼蓝排除法测定活细胞，并使用血细胞计数器进行定量[2]。",{"key":271,"value":272},"动物实验","将雌性Sprague-Dawley大鼠（250-275g），成年雌性SD大鼠（225-250g）随机分配至治疗组或媒介物组，使得每组的平均起始体重相等。药物治疗开始于手术当天或14天停药后重新加载的第一天。雷帕霉素每天一次通过腹膜内注射以1.5mg \u002F kg的剂量递送，溶于2％羧甲基纤维素中。 CsA每天一次通过皮下注射以15mg \u002F kg的剂量递送，溶于10％甲醇和橄榄油中。 FK506每天一次通过皮下注射以3mg \u002F kg的剂量递送，溶于10％乙醇，10％的cremophor和盐水中。将小鼠[5]雷帕霉素以20 mg \u002F mL的浓度溶解于乙醇中，过滤灭菌，重悬于载体（0.25％PEG，0.25％吐温-80）中，浓度为1 mg \u002F mL，腹腔注射（2 mg） \u002F kg体重），每天4周或每天4周，然后每周注射另外4周。注射开始于8周（肥大发作前）或12周（表明确定肥大后）的年龄，并在治疗4周后或治疗8周后评估小鼠，详见结果和图例。 。作为对照，WT和LS \u002F +小鼠仅用载体处理。",{"key":274,"value":275},"参考文献","[1].\nEdwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282(18), 13395-13401.\n[2].\nLalic H, et al. Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells. Leuk Lymphoma. 2012 Nov;53(11):2253-61.\n[3].\nTakeuchi H, et al. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase\u002Fprotein kinase B inhibitors. Cancer Res, 2005, 65(8), 3336-3346.\n[4].\nBodine SC, et al. Akt\u002FmTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol, 2001, 3(11), 1014-1019.\n[5].\nMarin TM, et al. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associatedPTPN11 mutation. 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(C...","162635-04-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F400\u002F162635-04-3.svg",[315],{"key":316,"value":317},"海关编码","2942000000",[319,322,324,327,330,333,336,339,342,345,348],{"key":320,"value":321},"符号","GHS02, GHS07",{"key":323,"value":240},"信号词",{"key":325,"value":326},"危害声明","H225-H302 + H312 + H332-H319",{"key":328,"value":329},"警示性声明","P210-P280-P305 + P351 + P338",{"key":331,"value":332},"个人防护装备","Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter",{"key":334,"value":335},"危害码 (欧洲)","Xi: Irritant;",{"key":337,"value":338},"风险声明 (欧洲)","R36\u002F38",{"key":340,"value":341},"安全声明 (欧洲)","S22-S24\u002F25",{"key":343,"value":344},"危险品运输编码","UN 1648 3 \u002F PGII",{"key":346,"value":347},"RTECS号","VE6250000",{"key":316,"value":317},"\u003Ctd>\n\n\u003Cp>\u003Cstrong>雷帕霉素生态学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp>对水是稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境。  \u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F53123-88-9_311098.html#duXinDiv\">雷帕霉素毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Ctd>\n\r\n                                        \r\n                                        雷帕霉素\n\u003Cb>修改号码：4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块1. 化学品\u003C\u002Fstrong>\n\u003Cbr \u002F> 产品名称：\n\u003Cb>Rapamycin\u003C\u002Fb>\n\u003Cbr \u002F> 修改号码：\n\u003Cb>4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>GHS分类\u003C\u002Fb>\n\u003Cbr \u002F> 　物理性危害未分类\n\u003Cbr \u002F> 　健康危害\n\u003Cbr \u002F> 特异性靶器官毒性免疫系统\n\u003Cbr \u002F>\n\u003Cb>- 单一接触 [第2级]\u003C\u002Fb>\n\u003Cbr \u002F> 特异性靶器官毒性免疫系统\n\u003Cbr \u002F>\n\u003Cb>- 单一接触 [第2级]\u003C\u002Fb>\n\u003Cbr \u002F> 　环境危害未分类\n\u003Cbr \u002F>\n\u003Cb>GHS标签元素\u003C\u002Fb>\n\u003Cbr \u002F> 　图标或危害标志\n\u003Cbr \u002F> 　信号词警告\n\u003Cbr \u002F> 　危险描述\n\u003Cbr \u002F> 可能对器官产生损害： 免疫系统\n\u003Cbr \u002F> 可能因延长或接触对器官产生损害： 免疫系统\n\u003Cbr \u002F> 　防范说明\n\u003Cbr \u002F>\n\u003Cb>[预防]\u003C\u002Fb>切勿吸入。\n\u003Cbr \u002F> 使用本产品时切勿吃东西，喝水或吸烟。\n\u003Cbr \u002F> 处理后要彻底清洗双手。\n\u003Cbr \u002F>\n\u003Cb>[急救措施]\u003C\u002Fb>\n\u003Cb>如接触到或感不适：呼叫解毒中心\u002F医生。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>[储存]\u003C\u002Fb>存放处须加锁。\n\u003Cbr \u002F>\n\u003Cb>[废弃处置]\u003C\u002Fb>\n\u003Cb>根据当地政府规定把物品\u002F容器交与工业废弃处理机构。\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>单一物质\u002F混和物\u003C\u002Fb>单一物质\n\u003Cbr \u002F>\n\u003Cb>化学名(中文名)：\u003C\u002Fb>雷帕霉素\n\u003Cbr \u002F> 百分比：\n\u003Cb>>98.0%(LC)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>CAS编码：\u003C\u002Fb>\n\u003Cb>53123-88-9\u003C\u002Fb>\n\u003Cbr \u002F> 雷帕霉素\n\u003Cb>修改号码：4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 分子式：\n\u003Cb>C51H79NO13\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 吸入：\n\u003Cb>将受害者移到新鲜空气处，保持呼吸通畅，休息。立即呼叫解毒中心\u002F医生。\u003C\u002Fb>\n\u003Cbr \u002F> 皮肤接触：\n\u003Cb>立即去除\u002F脱掉所有被污染的衣物。用大量肥皂和水轻轻洗。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>呼叫解毒中心\u002F医生。\u003C\u002Fb>\n\u003Cbr \u002F> 眼睛接触：用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。\n\u003Cbr \u002F>\n\u003Cb>立即呼叫解毒中心\u002F医生。\u003C\u002Fb>\n\u003Cbr \u002F> 食入：\n\u003Cb>呼叫解毒中心\u002F医生。漱口。\u003C\u002Fb>\n\u003Cbr \u002F> 紧急救助者的防护：救援者需要穿戴个人防护用品，比如橡胶手套和气密性护目镜。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块5. 消防措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 合适的灭火剂：干粉，泡沫，雾状水，二氧化碳\n\u003Cbr \u002F> 特殊危险性：小心，燃烧或高温下可能分解产生毒烟。\n\u003Cbr \u002F> 特定方法：从上风处灭火，根据周围环境选择合适的灭火方法。\n\u003Cbr \u002F> 非相关人员应该撤离至安全地方。\n\u003Cbr \u002F> 周围一旦着火：如果安全，移去可移动容器。\n\u003Cbr \u002F> 消防员的特殊防护用具：灭火时，一定要穿戴个人防护用品。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄漏应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F> 个人防护措施，防护用具，\n\u003Cb>使用特殊的个人防护用品（针对有毒颗粒的P3过滤式空气呼吸器）。远离溢出物\u002F泄露\u003C\u002Fb>\n\u003Cbr \u002F> 紧急措施：处并处在上风处。\n\u003Cbr \u002F> 泄露区应该用安全带等圈起来，控制非相关人员进入。\n\u003Cbr \u002F> 环保措施：防止进入下水道。\n\u003Cbr \u002F> 控制和清洗的方法和材料：清扫收集粉尘，封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的\n\u003Cbr \u002F> 法律法规处置。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块7. 操作处置与储存\u003C\u002Fstrong>\n\u003Cbr \u002F> 处理\n\u003Cbr \u002F> 技术措施：在通风良好处进行处理。穿戴合适的防护用具。防止粉尘扩散。处理后彻底清洗双手\n\u003Cbr \u002F> 和脸。\n\u003Cbr \u002F> 注意事项：如果可能，使用封闭系统。如果粉尘或浮质产生，使用局部排气。\n\u003Cbr \u002F> 操作处置注意事项：避免接触皮肤、眼睛和衣物。\n\u003Cbr \u002F> 贮存\n\u003Cbr \u002F> 储存条件：保持容器密闭。冷冻储存。\n\u003Cbr \u002F> 存放处须加锁。\n\u003Cbr \u002F> 远离不相容的材料比如氧化剂存放。\n\u003Cbr \u002F> 热敏\n\u003Cbr \u002F> 包装材料：依据法律。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F> 工程控制：尽可能安装封闭体系或局部排风系统。同时安装淋浴器和洗眼器。\n\u003Cbr \u002F> 个人防护用品\n\u003Cbr \u002F> 　呼吸系统防护：\n\u003Cb>防尘面具，自携式呼吸器（SCBA），供气呼吸器等。使用通过政府标准的呼吸器。依\u003C\u002Fb>\n\u003Cbr \u002F> 据当地和政府法规。\n\u003Cbr \u002F> 　手部防护：防渗手套。\n\u003Cbr \u002F> 　眼睛防护：护目镜。如果情况需要，佩戴面具。\n\u003Cbr \u002F> 　皮肤和身体防护：防渗防护服。如果情况需要，穿戴防护靴。\n\u003Cbr \u002F> 雷帕霉素\n\u003Cb>修改号码：4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F> 固体\n\u003Cbr \u002F>\n\u003Cb>外形（20°C）：\u003C\u002Fb>\n\u003Cbr \u002F> 外观：\n\u003Cb>晶体-粉末\u003C\u002Fb>\n\u003Cbr \u002F> 颜色：\n\u003Cb>白色-极淡的黄色\u003C\u002Fb>\n\u003Cbr \u002F> 气味：无资料\n\u003Cbr \u002F>\n\u003Cb>pH:\u003C\u002Fb>无数据资料\n\u003Cbr \u002F> 熔点：\n\u003Cb>177°C (分解)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>沸点\u002F沸程\u003C\u002Fb>无资料\n\u003Cbr \u002F> 闪点：无资料\n\u003Cbr \u002F> 爆炸特性\n\u003Cbr \u002F> 　爆炸下限：无资料\n\u003Cbr \u002F> 　爆炸上限：无资料\n\u003Cbr \u002F> 密度：无资料\n\u003Cbr \u002F> 溶解度：溶于： 甲醇 丙酮 氯仿 醚 二甲基甲酰胺\n\u003Cbr \u002F> 极微溶于： 正己烷 石油醚\n\u003Cbr \u002F> 不溶于： 水\n\u003Cbr \u002F>\n\u003Cb>log水分配系数 =\u003C\u002Fb>\n\u003Cb>4.81\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块10. 稳定性和反应性\u003C\u002Fstrong>\n\u003Cbr \u002F> 化学稳定性：一般情况下稳定。\n\u003Cbr \u002F> 危险反应的可能性：未报道特殊反应性。\n\u003Cbr \u002F> 须避免接触的物质氧化剂\n\u003Cbr \u002F>\n\u003Cb>危险的分解产物:\u003C\u002Fb>\n\u003Cb>一氧化碳, 二氧化碳, 氮氧化物 (NOx)\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块11. 毒理学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 急性毒性：\n\u003Cb>orl-mus LD50:>2500 mg\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>ipr-rat LD50:18220 ug\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F> 对皮肤腐蚀或刺激：无资料\n\u003Cbr \u002F> 对眼睛严重损害或刺激：无资料\n\u003Cbr \u002F> 生殖细胞变异原性：\n\u003Cb>mnt-hmn-lym 20 nmol\u002FL\u002F24H\u003C\u002Fb>\n\u003Cbr \u002F> 致癌性：\n\u003Cbr \u002F>\n\u003Cb>IARC =\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>NTP =\u003C\u002Fb>无资料\n\u003Cbr \u002F> 生殖毒性：无资料\n\u003Cbr \u002F>\n\u003Cb>RTECS 号码:\u003C\u002Fb>\n\u003Cb>VE6250000\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 生态毒性：\n\u003Cbr \u002F> 鱼类：无资料\n\u003Cbr \u002F> 甲壳类：无资料\n\u003Cbr \u002F> 藻类：无资料\n\u003Cbr \u002F>\n\u003Cb>残留性 \u002F 降解性：\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>潜在生物累积 （BCF):\u003C\u002Fb>无资料\n\u003Cbr \u002F> 土壤中移动性\n\u003Cbr \u002F>\n\u003Cb>　log水分配系数：\u003C\u002Fb>\n\u003Cb>4.81\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>　土壤吸收系数 （Koc）：\u003C\u002Fb>无资料\n\u003Cbr \u002F> 　亨利定律无资料\n\u003Cbr \u002F>\n\u003Cb>constant(PaM3\u002Fmol):\u003C\u002Fb>\n\u003Cbr \u002F> 雷帕霉素\n\u003Cb>修改号码：4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块13. 废弃处置\u003C\u002Fstrong>\n\u003Cbr \u002F> 如果可能，回收处理。请咨询当地管理部门。建议在可燃溶剂中溶解混合，在装有后燃和洗涤装置的化学焚烧炉中\n\u003Cbr \u002F> 焚烧。废弃处置时请遵守国家、地区和当地的所有法规。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块14. 运输信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 联合国分类：与联合国分类标准不一致\n\u003Cbr \u002F>\n\u003Cb>UN编号：\u003C\u002Fb>未列明\n\u003Cbr \u002F>\n\n\u003Cstrong>模块15. 法规信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>《危险化学品安全管理条例》（2002年1月26日国务院发布，2011年2月16日修订）: 针对危险化学品的安全使用、\u003C\u002Fb>\n\u003Cbr \u002F> 生产、储存、运输、装卸等方面均作了相应的规定。\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\u003Cbr \u002F>\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[354,360,366,372,378,384],{"slug":355,"cid":356,"name":357,"nameZh":358,"cas":359},"785894648240410624","J-1309348-8","Argireline","阿基瑞林","616204-22-9",{"slug":361,"cid":362,"name":363,"nameZh":364,"cas":365},"785880403549360128","J-1103503-3","lead,[c,c,c,c-tetrakis(1,1-dimethylethyl)-29h,31h-phthalocyaninato(2-)-kn29,kn30,kn31,kn32]- (9ci)","四叔丁基酞菁铅(Ⅱ)","158335-62-7",{"slug":367,"cid":368,"name":369,"nameZh":370,"cas":371},"785883052394942464","J-1108833-4","Trypan Blue","台盼蓝","72-57-1",{"slug":373,"cid":374,"name":375,"nameZh":376,"cas":377},"785894575947386880","J-38084-3","Prussian blue","亚铁(II)氰化铁(III)","14038-43-8",{"slug":379,"cid":380,"name":381,"nameZh":382,"cas":383},"785876805318873088","J-1108791-7","Coomassie brilliant blue G-250","考马斯亮蓝G250","6104-58-1",{"slug":385,"cid":386,"name":387,"nameZh":388,"cas":389},"785898371561820160","J-50381-7","Hemicellulase","半纤维素酶","9025-56-3",1792630583045,"zh-CN",[]]