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[3]。",{"key":276,"value":277},"细胞实验","用10μM浓度的α-雌二醇（17α-E2）或17β-E2处理小鼠胚胎成纤维细胞（MEF）细胞指定的时间。单独或与各自的雌激素组合，LPS以10ng \u002F mL的浓度诱导炎症[2]。",{"key":279,"value":280},"动物实验","根据治疗方式将新生小鼠随机分为6组：室内空气注射媒介物（对照组，第1组），车辆注射高氧（对照组，第2组），高氧用0.01μgα-雌二醇注射（第3组）高氧，0.1μgα-雌二醇注射（第4组），高氧与1.0μgα-雌二醇注射（第5组），高氧与1.0μgα-雌二醇和10.0μgICI182780注射（雌激素受体α和β的拮抗剂）（第6组）。幼仔每天皮下注射载体中的α-雌二醇[溶于乙醇并在0.05mL \u002F小鼠的磷酸盐缓冲盐水（PBS）中稀释]或从出生后天（PND）7-16单独的载体。在PND 7，高氧和α-雌二醇治疗组的幼鼠暴露于高氧（75±2％O2）5天（PND 7-12），然后恢复到常氧（室内空气）5天，与哺乳母亲一起，而常氧组中的幼崽从7-17号PND保持常氧。在PND 9,13（14）和17 [3]上对幼崽进行人道安乐死。",{"key":282,"value":283},"参考文献","[1].\nSchriefers H, et al. Inhibition of testosterone metabolism by 17-alpha-estradiol in rat liver slices. Arzneimittelforschung. 1991 Nov;41(11):1186-9.\n[2].\nSantos RS, et al. The effects of 17 alpha-estradiol to inhibit inflammation in vitro. Biol Sex Differ. 2017 Sep 6;8:30.\n[3].\nZhang HB, et al. 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model. 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Jul;56(4):407-15.",[285,291,297,303,309,315],{"slug":286,"cid":287,"name":288,"nameZh":288,"cas":289,"imgSvg":290},"785897616712929300","J-1986826-9","雌酚酮","53-16-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F086\u002F53-16-7.svg",{"slug":292,"cid":293,"name":294,"nameZh":294,"cas":295,"imgSvg":296},"785891923498897400","J-31539-9","正戊醇","71-41-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F411\u002F71-41-0.svg",{"slug":298,"cid":299,"name":300,"nameZh":300,"cas":301,"imgSvg":302},"785881931408478200","J-1117663-9","17ALFA-双氢马烯雌酮","6639-99-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F220\u002F6639-99-2.svg",{"slug":304,"cid":305,"name":306,"nameZh":306,"cas":307,"imgSvg":308},"785897256950698000","J-1519978-7","1,3,5-三硝基苯","99-35-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F038\u002F99-35-4.svg",{"slug":310,"cid":311,"name":312,"nameZh":312,"cas":313,"imgSvg":314},"785893833480081400","J-1327518-8","乙醇","64-17-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F081\u002F64-17-5.svg",{"slug":316,"cid":317,"name":318,"nameZh":318,"cas":319,"imgSvg":320},"785882976159273000","J-1148770-0","异丙醇铝","555-31-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F408\u002F555-31-7.svg",[322],{"slug":323,"cid":324,"name":325,"nameZh":325,"cas":326,"imgSvg":327},"785891925243727900","J-31545-7","雌二醇","50-28-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F341\u002F50-28-2.svg",[],[330,333,335,338,341,344,347,350,353,356,359],{"key":331,"value":332},"符号","GHS08",{"key":334,"value":255},"信号词",{"key":336,"value":337},"危害声明","H351",{"key":339,"value":340},"警示性声明","P281",{"key":342,"value":343},"个人防护装备","dust 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修改号码：\n\u003Cb>4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>GHS分类\u003C\u002Fb>\n\u003Cbr \u002F> 　物理性危害未分类\n\u003Cbr \u002F> 　健康危害\n\u003Cbr \u002F> 致癌性\n\u003Cb>第2级\u003C\u002Fb>\n\u003Cbr \u002F> 　环境危害未分类\n\u003Cbr \u002F>\n\u003Cb>GHS标签元素\u003C\u002Fb>\n\u003Cbr \u002F> 　图标或危害标志\n\u003Cbr \u002F> 　信号词警告\n\u003Cbr \u002F> 　危险描述怀疑会致癌\n\u003Cbr \u002F> 　防范说明\n\u003Cbr \u002F>\n\u003Cb>[预防]\u003C\u002Fb>使用前获取特定手册。\n\u003Cbr \u002F> 处理前必须阅读并理解所有安全措施。\n\u003Cbr \u002F> 使用个人所需的防护用具。\n\u003Cbr \u002F>\n\u003Cb>[急救措施]\u003C\u002Fb>\n\u003Cb>如接触到或相关接触：求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>[储存]\u003C\u002Fb>存放处须加锁。\n\u003Cbr \u002F>\n\u003Cb>[废弃处置]\u003C\u002Fb>\n\u003Cb>根据当地政府规定把物品\u002F容器交与工业废弃处理机构。\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>单一物质\u002F混和物\u003C\u002Fb>单一物质\n\u003Cbr \u002F>\n\u003Cb>化学名(中文名)：\u003C\u002Fb>\n\u003Cb>α-雌二醇\u003C\u002Fb>\n\u003Cbr \u002F> 百分比：\n\u003Cb>>98.0%(GC)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>CAS编码：\u003C\u002Fb>\n\u003Cb>57-91-0\u003C\u002Fb>\n\u003Cbr \u002F> 分子式：\n\u003Cb>C18H24O2\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 吸入：\n\u003Cb>将受害者移到新鲜空气处，保持呼吸通畅，休息。求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>α-雌二醇\u003C\u002Fb>\n\u003Cb>修改号码：4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 皮肤接触：\n\u003Cb>立即去除\u002F脱掉所有被污染的衣物。用大量肥皂和水轻轻洗。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 眼睛接触：用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。\n\u003Cbr \u002F>\n\u003Cb>求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 食入：\n\u003Cb>求医\u002F就诊。漱口。\u003C\u002Fb>\n\u003Cbr \u002F> 紧急救助者的防护：救援者需要穿戴个人防护用品，比如橡胶手套和气密性护目镜。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块5. 消防措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 合适的灭火剂：干粉，泡沫，雾状水，二氧化碳\n\u003Cbr \u002F> 特定方法：从上风处灭火，根据周围环境选择合适的灭火方法。\n\u003Cbr \u002F> 非相关人员应该撤离至安全地方。\n\u003Cbr \u002F> 周围一旦着火：如果安全，移去可移动容器。\n\u003Cbr \u002F> 消防员的特殊防护用具：灭火时，一定要穿戴个人防护用品。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄漏应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F> 个人防护措施，防护用具，\n\u003Cb>使用特殊的个人防护用品（针对有毒颗粒的P3过滤式空气呼吸器）。远离溢出物\u002F泄露\u003C\u002Fb>\n\u003Cbr \u002F> 紧急措施：处并处在上风处。\n\u003Cbr \u002F> 泄露区应该用安全带等圈起来，控制非相关人员进入。\n\u003Cbr \u002F> 环保措施：防止进入下水道。\n\u003Cbr \u002F> 控制和清洗的方法和材料：清扫收集粉尘，封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的\n\u003Cbr \u002F> 法律法规处置。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块7. 操作处置与储存\u003C\u002Fstrong>\n\u003Cbr \u002F> 处理\n\u003Cbr \u002F> 技术措施：在通风良好处进行处理。穿戴合适的防护用具。防止粉尘扩散。处理后彻底清洗双手\n\u003Cbr \u002F> 和脸。\n\u003Cbr \u002F> 注意事项：如果可能，使用封闭系统。如果粉尘或浮质产生，使用局部排气。\n\u003Cbr \u002F> 操作处置注意事项：避免所有部位的接触！\n\u003Cbr \u002F> 贮存\n\u003Cbr \u002F> 储存条件：保持容器密闭。存放于凉爽、阴暗处。\n\u003Cbr \u002F> 存放处须加锁。\n\u003Cbr \u002F> 远离不相容的材料比如氧化剂存放。\n\u003Cbr \u002F> 包装材料：依据法律。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F> 工程控制：尽可能安装封闭体系或局部排风系统。同时安装淋浴器和洗眼器。\n\u003Cbr \u002F> 个人防护用品\n\u003Cbr \u002F> 　呼吸系统防护：\n\u003Cb>防尘面具，自携式呼吸器（SCBA），供气呼吸器等。使用通过政府标准的呼吸器。依\u003C\u002Fb>\n\u003Cbr \u002F> 据当地和政府法规。\n\u003Cbr \u002F> 　手部防护：防渗手套。\n\u003Cbr \u002F> 　眼睛防护：护目镜。如果情况需要，佩戴面具。\n\u003Cbr \u002F> 　皮肤和身体防护：防渗防护服。如果情况需要，穿戴防护靴。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F> 固体\n\u003Cbr \u002F>\n\u003Cb>外形（20°C）：\u003C\u002Fb>\n\u003Cbr \u002F> 外观：\n\u003Cb>晶体-粉末\u003C\u002Fb>\n\u003Cbr \u002F> 颜色：\n\u003Cb>白色-微浅黄色\u003C\u002Fb>\n\u003Cbr \u002F> 气味：无资料\n\u003Cbr \u002F>\n\u003Cb>pH:\u003C\u002Fb>无数据资料\n\u003Cbr \u002F>\n\u003Cb>α-雌二醇\u003C\u002Fb>\n\u003Cb>修改号码：4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F> 熔点：\n\u003Cb>224°C\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>沸点\u002F沸程\u003C\u002Fb>无资料\n\u003Cbr \u002F> 闪点：无资料\n\u003Cbr \u002F> 爆炸特性\n\u003Cbr \u002F> 　爆炸下限：无资料\n\u003Cbr \u002F> 　爆炸上限：无资料\n\u003Cbr \u002F> 密度：无资料\n\u003Cbr \u002F> 溶解度：溶于： 热二氧六环\n\u003Cbr \u002F>\n\n\u003Cstrong>模块10. 稳定性和反应性\u003C\u002Fstrong>\n\u003Cbr \u002F> 化学稳定性：一般情况下稳定。\n\u003Cbr \u002F> 危险反应的可能性：未报道特殊反应性。\n\u003Cbr \u002F> 须避免接触的物质氧化剂\n\u003Cbr \u002F>\n\u003Cb>危险的分解产物:\u003C\u002Fb>\n\u003Cb>一氧化碳, 二氧化碳\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块11. 毒理学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 急性毒性：无资料\n\u003Cbr \u002F> 对皮肤腐蚀或刺激：无资料\n\u003Cbr \u002F> 对眼睛严重损害或刺激：无资料\n\u003Cbr \u002F> 生殖细胞变异原性：\n\u003Cb>dni-hmn-oth 100 mg\u002FL\u003C\u002Fb>\n\u003Cbr \u002F> 致癌性：\n\u003Cb>ims-gpg TDLo:3 mg\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>IARC =\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>NTP =\u003C\u002Fb>无资料\n\u003Cbr \u002F> 生殖毒性：无资料\n\u003Cbr \u002F>\n\u003Cb>RTECS 号码:\u003C\u002Fb>\n\u003Cb>KG3750000\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 生态毒性：\n\u003Cbr \u002F> 鱼类：无资料\n\u003Cbr \u002F> 甲壳类：无资料\n\u003Cbr \u002F> 藻类：无资料\n\u003Cbr \u002F>\n\u003Cb>残留性 \u002F 降解性：\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>潜在生物累积 （BCF):\u003C\u002Fb>无资料\n\u003Cbr \u002F> 土壤中移动性\n\u003Cbr \u002F>\n\u003Cb>　log水分配系数：\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>　土壤吸收系数 （Koc）：\u003C\u002Fb>无资料\n\u003Cbr \u002F> 　亨利定律无资料\n\u003Cbr \u002F>\n\u003Cb>constant(PaM3\u002Fmol):\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块13. 废弃处置\u003C\u002Fstrong>\n\u003Cbr \u002F> 如果可能，回收处理。请咨询当地管理部门。建议在可燃溶剂中溶解混合，在装有后燃和洗涤装置的化学焚烧炉中\n\u003Cbr \u002F> 焚烧。废弃处置时请遵守国家、地区和当地的所有法规。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块14. 运输信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 联合国分类：与联合国分类标准不一致\n\u003Cbr \u002F>\n\u003Cb>UN编号：\u003C\u002Fb>未列明\n\u003Cbr \u002F>\n\n\u003Cstrong>模块15. 法规信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>《危险化学品安全管理条例》（2002年1月26日国务院发布，2011年2月16日修订）: 针对危险化学品的安全使用、\u003C\u002Fb>\n\u003Cbr \u002F> 生产、储存、运输、装卸等方面均作了相应的规定。\n\u003Cbr \u002F>\n\u003Cb>α-雌二醇\u003C\u002Fb>\n\u003Cb>修改号码：4\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\u003Cbr \u002F>\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[368,374,380,386,392,398,404,410,416,422,428,434],{"slug":369,"cid":370,"name":371,"nameZh":372,"cas":373},"785889099062972416","J-26435-7","4-(4-Nitrophenylazo)orcinol","4-(4-硝基苯基偶氮)苔黑酚","607-96-5",{"slug":375,"cid":376,"name":377,"nameZh":378,"cas":379},"785883139921678336","J-7231-1","4,4,5,5,6,6,7,7,7-Nonafluoroheptan-1-ol","4,4,5,5,6,6,7,7,7-九氟-1-庚醇","83310-97-8",{"slug":381,"cid":382,"name":383,"nameZh":384,"cas":385},"785883245123211264","J-7646-0","Dienestrol","双烯雌酚","84-17-3",{"slug":387,"cid":388,"name":389,"nameZh":390,"cas":391},"785872595349147648","J-1992474-4","3,3,4,4,5,5,6,6,6-nonafluoro-1-hexanethiol","3,3,4,4,5,5,6,6,6-九氟-1-己硫醇","34451-25-7",{"slug":393,"cid":394,"name":395,"nameZh":396,"cas":397},"785893067268820992","J-819402-3","Tyloxapol","四丁酚醇","25301-02-4",{"slug":399,"cid":400,"name":401,"nameZh":402,"cas":403},"785883130899730432","J-7174-9","2,2,3,3,4,4,5,5-Octafluoro-1,6-hexanediol","2,2,3,3,4,4,5,5-八氟-1,6-己二醇","355-74-8",{"slug":405,"cid":406,"name":407,"nameZh":408,"cas":409},"785897617765699584","J-47482-8","Estriol","雌三醇","50-27-1",{"slug":411,"cid":412,"name":413,"nameZh":414,"cas":415},"785892627638652928","J-33176-0","2,6-Dichloroindophenol sodium salt","2,6-二氯靛酚钠","620-45-1",{"slug":417,"cid":418,"name":419,"nameZh":420,"cas":421},"785882642795991040","J-5184-3","1H,1H-Nonafluoro-1-pentanol","1H,1H-九氟-1-戊醇","355-28-2",{"slug":423,"cid":424,"name":425,"nameZh":426,"cas":427},"785897951850401792","J-48487-7","D-erythro-Sphingosine","D-鞘氨醇","123-78-4",{"slug":429,"cid":430,"name":431,"nameZh":432,"cas":433},"785883130081841152","J-7166-9","1H,1H-Undecafluoro-1-hexanol","1H,1H-十一氟-1-己醇","423-46-1",{"slug":435,"cid":436,"name":437,"nameZh":438,"cas":439},"785895160671113216","J-40201-7","Benzenemethanol, alpha,alpha-bis(trifluoromethyl)-","1,1,1,3,3,3-六氟-2-苯基-2-丙醇","718-64-9",1794252214411,"zh-CN",[]]