[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1659-1":171,"verified-suppliers-J-1659-1":318},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.689327,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":189,"ghs":228,"offers":229,"activity":230,"upstream":255,"downstream":274,"customs":275,"safetyRows":276,"updatedAt":277,"isProhibited":278,"related":279,"__ts":316,"__lang":317,"__slug":173},"785894178088292352","J-1659-1","\u002Fimages\u002Fchem_structures_svg\u002F489\u002F1224844-38-5.svg","沙帕色替","1224844-38-5","C15H15N7O","309.326","organic","有机化合物","Organic Compounds",[],[184,185,186,187,188],"3-(2-氨基-5-苯并噁唑基)-1-(1-甲基乙基)-1H-吡唑并[3,4-d]嘧啶-4-胺","5-(4-氨基-1-异丙基-1H-吡唑并[3,4-d]嘧啶-3-基)苯并[d]噁唑-2-胺","INK-128","MLN0128","萨帕尼塞替",[190,195,200,205,209,213,216,220,224],{"label":191,"labelZh":192,"value":193,"prop":194},"Boiling Point","沸点","598.8±60.0 °C at 760 mmHg","boilingPoint",{"label":196,"labelZh":197,"value":198,"prop":199},"Density","密度","1.6±0.1 g\u002Fcm3","density",{"label":201,"labelZh":202,"value":203,"prop":204},"Flash Point","闪点","315.9±32.9 °C","flashPoint",{"label":206,"labelZh":207,"value":208},"Exact Mass","精确质量","309.133820",{"label":210,"labelZh":211,"value":212},"PSA","其他信息","121.67000",{"label":214,"labelZh":214,"value":215},"LogP","1.95",{"label":217,"labelZh":218,"value":219},"Vapor Pressure","蒸汽压","0.0±1.7 mmHg at 25°C",{"label":221,"labelZh":222,"value":223},"Refractive Index","折射率","1.829",{"label":225,"labelZh":226,"value":227},"Storage Conditions","储存条件","-20°C",null,[],[231,234,237,240,243,246,249,252],{"key":232,"value":233},"描述","Sapanisertib (INK-128) 是ATP依赖性的 mTOR1\u002F2 抑制剂,抑制mTOR激酶的IC50 值为1 nM。",{"key":235,"value":236},"相关类别","信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\nPI3K\u002FAkt\u002FmTOR 信号通路\n>>\nmTOR\n研究领域\n>>\n癌症",{"key":238,"value":239},"靶点","mTOR:1 nM (IC50)\nmTORC1\nmTORC2\nPI3Kα:219 nM (IC50)\nPI3Kβ:5.293 μM (IC50)\nPI3Kδ:230 nM (IC50)\nPI3Kγ:221 nM (IC50)\nAutophagy",{"key":241,"value":242},"体外研究","Sapanisertib(INK-128)对mTOR具有酶抑制活性,对PI3K激酶具有100倍以上的选择性[1]。 Sapanisertib(INK-128)选择性地降低蛋白质中YB1,MTA1,波形蛋白和CD44的表达,但不降低PC3细胞中的转录水平。 Sapanisertib(INK-128)降低PC3前列腺癌细胞的侵袭潜力。此外,Sapanisertib(INK-128)在治疗6小时开始抑制癌细胞迁移,与促入侵袭基因表达减少明显相关,但在细胞周期或整体全球蛋白质合成的任何变化之前[2] ]。",{"key":244,"value":245},"体内研究","在ZR-75-1乳腺癌异种移植模型中,Sapanisertib(INK-128)在0.3mg\u002Fkg \u002F天的剂量下显示出肿瘤生长抑制功效[1]。在PtenL\u002FL小鼠中用INK128处理后,4EBP1和p70S6K1\u002F2磷酸化完全恢复到野生型水平。 Sapanisertib(INK-128)治疗导致PtenL\u002FL小鼠前列腺上皮内瘤变(PIN)损伤减少50％,并在小鼠的多种癌细胞系中诱导程序性细胞死亡[2]。",{"key":247,"value":248},"细胞实验","用合适的药物处理PC3细胞48小时，并使用CellTiter-Glo发光试剂测量增殖。使用浓度范围为20.0μM至0.1nM（12点曲线）计算实现细胞生长抑制50％所需的萨潘替尼（INK-128）浓度（IC 50）。",{"key":250,"value":251},"动物实验","裸鼠在右肩胛下区域皮下接种5×106个MDA-MB-361细胞。在肿瘤达到150-200mm 3的大小后，将小鼠随机分配到载体对照组或治疗组中。 Sapanisertib（INK-128）配制成5％聚乙烯丙炔，15％NMP，80％水，并通过口服强饲法以0.3mg \u002F kg和1mg \u002F kg每天施用。",{"key":253,"value":254},"参考文献","[1].\nLiu A, et al. mTOR Mediated Anti-Cancer Drug Discovery. Drug Discovery Today: Therapeutic Strategies. 2009, 6(2), 47-55.\n[2].\nHsieh AC, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22;485(7396):55-61.",[256,262,268],{"slug":257,"cid":258,"name":259,"nameZh":259,"cas":260,"imgSvg":261},"785889615008501800","J-1365905-9","3-溴-1H-吡唑并[3,4-...","83255-86-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F164\u002F83255-86-1.svg",{"slug":263,"cid":264,"name":265,"nameZh":265,"cas":266,"imgSvg":267},"785897906061185000","J-48345-4","2-氨基-4-溴苯酚","40925-68-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F332\u002F40925-68-6.svg",{"slug":269,"cid":270,"name":271,"nameZh":271,"cas":272,"imgSvg":273},"785897919294214100","J-904340-0","2-氨基-5-溴苯并恶唑","64037-07-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F211\u002F64037-07-6.svg",[],[],[],"2026-08-21T07:51:12.859463Z",false,[280,286,292,298,304,310],{"slug":281,"cid":282,"name":283,"nameZh":284,"cas":285},"785884688790065152","J-1109893-1","Alizarin yellow GG","茜素黄GG","584-42-9",{"slug":287,"cid":288,"name":289,"nameZh":290,"cas":291},"847438775779856384","J-1134038-0","1,5-dimethyl-4-[[(Z)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-2-phenylpyrazol-3-one","水杨醛缩4-氨基安替比林","30957-66-5",{"slug":293,"cid":294,"name":295,"nameZh":296,"cas":297},"785875984183201792","J-11597-3","Aflatoxin B1","黄曲霉毒素B1","1162-65-8",{"slug":299,"cid":300,"name":301,"nameZh":302,"cas":303},"785882574307201024","J-4791-1","Azure B","天青B","531-55-5",{"slug":305,"cid":306,"name":307,"nameZh":308,"cas":309},"785892364030840832","J-1381949-5","Alcloxa","铝克洛沙","1317-25-5",{"slug":311,"cid":312,"name":313,"nameZh":314,"cas":315},"785882530409615360","J-1955871-6","Febuxostat","非布索坦","144060-53-7",1792658227045,"zh-CN",[]]