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Hazard","Danger",[],[],[249,252,255,258,261,264,267,270],{"key":250,"value":251},"描述","Celecoxib 是一种选择性的 COX-2 抑制剂,IC50 为 40 nM。",{"key":253,"value":254},"相关类别","信号通路\n>>\n免疫及炎症\n>>\nCOX\n研究领域\n>>\n炎症\u002F免疫",{"key":256,"value":257},"靶点","COX-2:40 nM (IC50)\nCOX-1:15 μM (IC50)",{"key":259,"value":260},"体外研究","选择性环加氧酶-2(COX-2)抑制剂塞来昔布(10-75μM)以剂量依赖性方式抑制NPC细胞系的增殖。塞来昔布(25和50μM)诱导NPC细胞系中G0\u002FG1检查点的细胞凋亡和细胞周期停滞,这与STAT3磷酸化显着降低有关。 STAT3下游的基因(即Survivin,Mcl-1,Bcl-2和Cyclin D1)在暴露于塞来昔布(25和50μM)后显着下调[2]。",{"key":262,"value":263},"体内研究","塞来昔布表现出有效的口服抗炎活性。塞来昔布在角叉菜胶水肿试验中减少急性炎症,ED50为7.1mg\u002Fkg,并且在佐剂关节炎模型中减少慢性炎症,ED50为0.37mg\u002Fkg \u002F天。此外,塞来昔布在Hargreaves痛觉过敏模型中也表现出镇痛活性,ED50为34.5mg\u002Fkg。塞来昔布具有与标准非甾体抗炎药(NSAID)相当的效力,但在剂量高达200mg\u002Fkg的大鼠中没有表现出急性GI毒性。此外,在10天内剂量高达600 mg\u002Fkg \u002F天的大鼠中没有显示出慢性GI毒性[1]。在喂食高脂肪饮食(肥胖)并用塞来昔布治疗的KpB小鼠中,与对照动物相比,肿瘤重量减少66％。在喂食低脂饮食(非肥胖)的KpB小鼠中,用塞来昔布治疗后肿瘤重量减少了46％[3]。大鼠模型口服给塞来昔布(20mg\u002Fkg)和\u002F或肌肉注射法舒地尔(10mg\u002Fkg)2周。结果表明,联合使用塞来昔布和法舒地尔可显着降低脊髓损伤大鼠病灶周围COX-2和Rho激酶II的表达,改善损伤脊髓的病理形态,促进运动功能的恢复[4] 。",{"key":265,"value":266},"细胞实验","使用MTT测定评估塞来昔布对NPC细胞的抗增殖作用。将细胞接种到96孔板中并使其附着24小时。然后用溶解在DMSO中的递增浓度的塞来昔布（0,5,10,25,50或75μM）处理细胞（终浓度≤0.1％）并孵育最多48小时。温育后，向每个孔中加入20μLMTT染料（5mg \u002F mL），并将细胞在37℃下孵育4小时。除去上清液后，将晶体溶解在DMSO中，在490nm处测量吸光度。生长抑制百分比计算为（ODcontrol-ODdrug）\u002F ODcontrol×100％。使用SPSS 15.0软件使用概率回归计算半数最大抑制浓度（IC 50）值和95％置信区间。实验一式三份进行，并重复至少三次[2]。",{"key":268,"value":269},"动物实验","小鼠[3]通过触诊每周监测KpB小鼠的肿瘤生长。在HFD（肥胖组）和LFD（非肥胖组）（每组N = 15只小鼠）的小鼠中触诊1cm肿瘤后开始塞来昔布和安慰剂治疗。塞来昔布以5mg \u002F mL溶解在DMSO中，在含有0.025％吐温80的0.5％甲基纤维素中进一步稀释10倍，并且每天以5mg \u002F kg体重的剂量注射（IP）4周。通过触诊每周测量一次肿瘤大小。使用以下等式计算肿瘤体积：体积（mm 3）= a×b2 \u002F 2，其中最大直径，b是最小直径。在整个研究期间每周称重动物。在处死时，称重小鼠并取血样。将一半的卵巢肿瘤快速冷冻并储存在-80℃，另一半固定在10％中性缓冲的福尔马林中并石蜡包埋。还收获小鼠心脏，肺和肾脏，用福尔马林固定，并在石蜡包埋前仔细检查任何可疑病变。大鼠[4]使用40只3月龄，体重280-330g的成年，清洁，雌性，Sprague-Dawley大鼠。将40只大鼠随机分为5组：假手术，模型，塞来昔布，法舒地尔和联合用药组，每组8只。塞来昔布组的大鼠用塞来昔布（20mg \u002F kg）的悬浮液灌胃给药，由胶囊制备含有0.5％羧甲基纤维素钠的塞来昔布悬浮液。法舒地尔组大鼠通过背部肌肉注射盐酸法舒地尔（10mg \u002F kg）肌内注射。联合组大鼠给予塞来昔布（20mg \u002F kg）和法舒地尔盐酸盐（10mg \u002F kg）的悬浮液。法舒地尔和塞来昔布剂量基于给予成人的剂量，并且这些剂量在预研究中进行调整。每天给药一次，持续2周。随后，将所有大鼠正常治疗另外2周，然后处死用于组织学检查或用于蛋白质印迹分析。",{"key":271,"value":272},"参考文献","[1].\nPenning TD, et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J Med Chem. 1997\n[2].\nLiu DB, et al. Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation. Acta Pharmacol Sin. 2012 May;33(5):682-90.\n[3].\nSuri A, et al. The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer. Oncotarget. 2016 Apr 8.\n[4].\nHou XL, et al. Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone. Neural Regen Res. 2015 Nov;10(11):1836-40.\n[5].\nLiu C, et al. Celecoxib alleviates nonalcoholic fatty liver disease by restoring autophagic flux. Sci Rep. 2018 Mar 7;8(1):4108.",[274,280,286,292,298],{"slug":275,"cid":276,"name":277,"nameZh":277,"cas":278,"imgSvg":279},"785896710814568400","J-921961-8","4,4,4-三氟-1-(4-甲...","720-94-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F407\u002F720-94-5.svg",{"slug":281,"cid":282,"name":283,"nameZh":283,"cas":284,"imgSvg":285},"785897941788266500","J-1103864-3","对氨磺酰基苯肼盐酸盐","17852-52-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F397\u002F17852-52-7.svg",{"slug":287,"cid":288,"name":289,"nameZh":289,"cas":290,"imgSvg":291},"785896621022908400","J-44680-2","三氟乙酸乙酯","383-63-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F268\u002F383-63-1.svg",{"slug":293,"cid":294,"name":295,"nameZh":295,"cas":296,"imgSvg":297},"785897814184955900","J-48018-1","对甲基苯乙酮","122-00-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F332\u002F122-00-9.svg",{"slug":299,"cid":300,"name":301,"nameZh":301,"cas":302,"imgSvg":303},"785872083987992600","J-994232-9","4-肼基苯磺酰胺","4392-54-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F408\u002F4392-54-5.svg",[305],{"slug":306,"cid":307,"name":308,"nameZh":308,"cas":309,"imgSvg":310},"785894930512875500","J-1505929-1","4-[5-(4-羟基甲基苯基)...","170571-00-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F466\u002F170571-00-3.svg",[312,315,318,321],{"key":313,"value":314},"海关编码","2935009090",{"key":316,"value":317},"中文概述","2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%",{"key":319,"value":320},"申报要素","品名, 成分含量, 用途",{"key":322,"value":323},"Summary","2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%",[325,328,330,333,336,339,342,345,348,351],{"key":326,"value":327},"符号","GHS08",{"key":329,"value":245},"信号词",{"key":331,"value":332},"危害声明","H360D",{"key":334,"value":335},"警示性声明","P201-P308 + P313",{"key":337,"value":338},"危害码 (欧洲)","Xn",{"key":340,"value":341},"风险声明 (欧洲)","R20\u002F21\u002F22",{"key":343,"value":344},"安全声明 (欧洲)","S22-S24\u002F25-S28-S37\u002F39",{"key":346,"value":347},"危险品运输编码","UN 2811",{"key":349,"value":350},"RTECS号","DB2944937",{"key":313,"value":314},"\u003Ctd>\n\n\n\u003Cstrong>模块1. 化学品\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>1.1 产品标识符\u003C\u002Fb>\n\u003Cbr \u002F> : Celecoxib\n\u003Cbr \u002F> 产品名称\n\u003Cbr \u002F>\n\u003Cb>1.2 鉴别的其他方法\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>1.3 有关的确定了的物质或混合物的用途和建议不适合的用途\u003C\u002Fb>\n\u003Cbr \u002F> 仅用于研发。不作为药品、家庭或其它用途。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>2.1 GHS-分类\u003C\u002Fb>\n\u003Cbr \u002F> 急性毒性, 经口 (类别 5)\n\u003Cbr \u002F> 生殖毒性 (类别 1B)\n\u003Cbr \u002F> 急性水生毒性 (类别 2)\n\u003Cbr \u002F>\n\u003Cb>2.2 GHS 标记要素，包括预防性的陈述\u003C\u002Fb>\n\u003Cbr \u002F> 象形图\n\u003Cbr \u002F> 警示词危险\n\u003Cbr \u002F> 危险申明\n\u003Cbr \u002F> H303吞咽可能有害。\n\u003Cbr \u002F> H360可能对生育能力或胎儿造成伤害。\n\u003Cbr \u002F> H401对水生生物有毒。\n\u003Cbr \u002F> 警告申明\n\u003Cbr \u002F> 预防措施\n\u003Cbr \u002F> P201在使用前获取特别指示。\n\u003Cbr \u002F> P202在读懂所有安全防范措施之前切勿操作。\n\u003Cbr \u002F> P273避免释放到环境中。\n\u003Cbr \u002F> P280戴防护手套\u002F穿防护服\u002F戴护目镜\u002F戴面罩.\n\u003Cbr \u002F> 事故响应\n\u003Cbr \u002F> P308 + P313如接触到或有疑虑：求医\u002F 就诊。\n\u003Cbr \u002F> 安全储存\n\u003Cbr \u002F> P405存放处须加锁。\n\u003Cbr \u002F> 废弃处置\n\u003Cbr \u002F> P501将内容物\u002F 容器处理到得到批准的废物处理厂。\n\u003Cbr \u002F> 只限于专业使用者。\n\u003Cbr \u002F>\n\u003Cb>2.3 其它危害物 - 无\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>3.1 物 质\u003C\u002Fb>\n\u003Cbr \u002F> : C17H14F3N3O2S\n\u003Cbr \u002F> 分子式\n\u003Cbr \u002F> : 381.37 g\u002Fmol\n\u003Cbr \u002F> 分子量\n\u003Cbr \u002F> 组分浓度或浓度范围\n\u003Cbr \u002F> Celecoxib\n\u003Cbr \u002F> <=100%\n\u003Cbr \u002F> 化学文摘登记号(CAS169590-42-5\n\u003Cbr \u002F> No.)\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>4.1 必要的急救措施描述\u003C\u002Fb>\n\u003Cbr \u002F> 一般的建议\n\u003Cbr \u002F> 请教医生。 向到现场的医生出示此安全技术说明书。\n\u003Cbr \u002F> 吸入\n\u003Cbr \u002F> 如果吸入,请将患者移到新鲜空气处。 如呼吸停止,进行人工呼吸。 请教医生。\n\u003Cbr \u002F> 皮肤接触\n\u003Cbr \u002F> 用肥皂和大量的水冲洗。 请教医生。\n\u003Cbr \u002F> 眼睛接触\n\u003Cbr \u002F> 用水冲洗眼睛作为预防措施。\n\u003Cbr \u002F> 食入\n\u003Cbr \u002F> 切勿给失去知觉者通过口喂任何东西。 用水漱口。 请教医生。\n\u003Cbr \u002F>\n\u003Cb>4.2 主要症状和影响，急性和迟发效应\u003C\u002Fb>\n\u003Cbr \u002F> 据我们所知，此化学，物理和毒性性质尚未经完整的研究。\n\u003Cbr \u002F>\n\u003Cb>4.3 及时的医疗处理和所需的特殊处理的说明和指示\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块5. 消防措施\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>5.1 灭火介质\u003C\u002Fb>\n\u003Cbr \u002F> 灭火方法及灭火剂\n\u003Cbr \u002F> 用水雾,抗乙醇泡沫,干粉或二氧化碳灭火。\n\u003Cbr \u002F>\n\u003Cb>5.2 源于此物质或混合物的特别的危害\u003C\u002Fb>\n\u003Cbr \u002F> 碳氧化物, 氮氧化物, 硫氧化物, 氟化氢\n\u003Cbr \u002F>\n\u003Cb>5.3 给消防员的建议\u003C\u002Fb>\n\u003Cbr \u002F> 如必要的话,戴自给式呼吸器去救火。\n\u003Cbr \u002F>\n\u003Cb>5.4 进一步信息\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄露应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>6.1 作业人员防护措施、防护装备和应急处置程序\u003C\u002Fb>\n\u003Cbr \u002F> 使用个人防护用品。 避免粉尘生成。 避免吸入蒸气、烟雾或气体。 保证充分的通风。\n\u003Cbr \u002F> 人员疏散到安全区域。 避免吸入粉尘。\n\u003Cbr \u002F>\n\u003Cb>6.2 环境保护措施\u003C\u002Fb>\n\u003Cbr \u002F> 如能确保安全，可采取措施防止进一步的泄漏或溢出。 不要让产品进入下水道。\n\u003Cbr \u002F> 一定要避免排放到周围环境中。\n\u003Cbr \u002F>\n\u003Cb>6.3 泄漏化学品的收容、清除方法及所使用的处置材料\u003C\u002Fb>\n\u003Cbr \u002F> 收集和处置时不要产生粉尘。 扫掉和铲掉。 放入合适的封闭的容器中待处理。\n\u003Cbr \u002F>\n\u003Cb>6.4 参考其他部分\u003C\u002Fb>\n\u003Cbr \u002F> 丢弃处理请参阅第13节。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块7. 操作处置与储存\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>7.1 安全操作的注意事项\u003C\u002Fb>\n\u003Cbr \u002F> 避免形成粉尘和气溶胶。避免曝露：使用前需要获得专门的指导。\n\u003Cbr \u002F> 在有粉尘生成的地方,提供合适的排风设备。\n\u003Cbr \u002F>\n\u003Cb>7.2 安全储存的条件,包括任何不兼容性\u003C\u002Fb>\n\u003Cbr \u002F> 贮存在阴凉处。 使容器保持密闭，储存在干燥通风处。\n\u003Cbr \u002F>\n\u003Cb>7.3 特定用途\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>8.1 容许浓度\u003C\u002Fb>\n\u003Cbr \u002F> 最高容许浓度\n\u003Cbr \u002F> 没有已知的国家规定的暴露极限。\n\u003Cbr \u002F>\n\u003Cb>8.2 暴露控制\u003C\u002Fb>\n\u003Cbr \u002F> 适当的技术控制\n\u003Cbr \u002F> 根据良好的工业卫生和安全规范进行操作。 休息前和工作结束时洗手。\n\u003Cbr \u002F> 个体防护设备\n\u003Cbr \u002F> 眼\u002F面保护\n\u003Cbr \u002F> 带有防护边罩的安全眼镜符合 EN166要求请使用经官方标准如NIOSH (美国) 或 EN 166(欧盟)\n\u003Cbr \u002F> 检测与批准的设备防护眼部。\n\u003Cbr \u002F> 皮肤保护\n\u003Cbr \u002F> 戴手套取 手套在使用前必须受检查。\n\u003Cbr \u002F> 请使用合适的方法脱除手套(不要接触手套外部表面),避免任何皮肤部位接触此产品.\n\u003Cbr \u002F> 使用后请将被污染过的手套根据相关法律法规和有效的实验室规章程序谨慎处理. 请清洗并吹干双手\n\u003Cbr \u002F> 所选择的保护手套必须符合EU的89\u002F686\u002FEEC规定和从它衍生出来的EN 376标准。\n\u003Cbr \u002F> 身体保护\n\u003Cbr \u002F> 防渗透的衣服, 防护设备的类型必须根据特定工作场所中的危险物的浓度和数量来选择。\n\u003Cbr \u002F> 呼吸系统防护\n\u003Cbr \u002F> 如危险性评测显示需要使用空气净化的防毒面具，请使用全面罩式多功能微粒防毒面具N100型（US\n\u003Cbr \u002F> ）或P3型（EN\n\u003Cbr \u002F> 143）防毒面具筒作为工程控制的候补。如果防毒面具是保护的唯一方式，则使用全面罩式送风防毒\n\u003Cbr \u002F> 面具。 呼吸器使用经过测试并通过政府标准如NIOSH（US）或CEN（EU）的呼吸器和零件。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>9.1 基本的理化特性的信息\u003C\u002Fb>\n\u003Cbr \u002F> a) 外观与性状\n\u003Cbr \u002F> 形状: 固体\n\u003Cbr \u002F> 颜色: 白色\n\u003Cbr \u002F> b) 气味\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> c) 气味阈值\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> d) pH值\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> e) 熔点\u002F凝固点\n\u003Cbr \u002F> 熔点\u002F凝固点: 156 - 157 °C\n\u003Cbr \u002F> f) 沸点、初沸点和沸程\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> g) 闪点\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> h) 蒸发速率\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> i) 易燃性(固体,气体)\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> j) 高的\u002F低的燃烧性或爆炸性限度 无数据资料\n\u003Cbr \u002F> k) 蒸气压\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> l) 蒸汽密度\n\u003Cbr \u002F> 13.17 - (空气= 1.0)\n\u003Cbr \u002F> m) 密度\u002F相对密度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> n) 水溶性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> o) n-辛醇\u002F水分配系数\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> p) 自燃温度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> q) 分解温度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> r) 粘度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块10. 稳定性和反应活性\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>10.1 反应性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.2 稳定性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.3 危险反应\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.4 应避免的条件\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.5 不相容的物质\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.6 危险的分解产物\u003C\u002Fb>\n\u003Cbr \u002F> 其它分解产物 - 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块11. 毒理学资料\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>11.1 毒理学影响的信息\u003C\u002Fb>\n\u003Cbr \u002F> 急性毒性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 皮肤刺激或腐蚀\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 眼睛刺激或腐蚀\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 呼吸道或皮肤过敏\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 生殖细胞致突变性\n\u003Cbr \u002F> 动物试验未见致突变影响。\n\u003Cbr \u002F> 致癌性\n\u003Cbr \u002F> 动物实验未见任何致癌影响。\n\u003Cbr \u002F> IARC:\n\u003Cbr \u002F> 此产品中没有大于或等于 0。1%含量的组分被 IARC鉴别为可能的或肯定的人类致癌物。\n\u003Cbr \u002F> 生殖毒性\n\u003Cbr \u002F> 有可能会损害胎儿。\n\u003Cbr \u002F> 假设的人类生殖毒物\n\u003Cbr \u002F> 假设的人类生殖毒物\n\u003Cbr \u002F> 特异性靶器官系统毒性（一次接触）\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 特异性靶器官系统毒性（反复接触）\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 吸入危险\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 潜在的健康影响\n\u003Cbr \u002F> 吸入吸入可能有害。 可能引起呼吸道刺激。\n\u003Cbr \u002F> 摄入如服入是有害的。\n\u003Cbr \u002F> 皮肤通过皮肤吸收可能有害。 可能引起皮肤刺激。\n\u003Cbr \u002F> 眼睛可能引起眼睛刺激。\n\u003Cbr \u002F> 接触后的征兆和症状\n\u003Cbr \u002F> 据我们所知，此化学，物理和毒性性质尚未经完整的研究。\n\u003Cbr \u002F> 附加说明\n\u003Cbr \u002F> 化学物质毒性作用登记: DB2944937\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学资料\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>12.1 生态毒性\u003C\u002Fb>\n\u003Cbr \u002F> 对鱼类的毒性半数致死浓度（LC50） - 肥头鲦鱼 (黑头软口鲦鱼) - > 1.2 mg\u002Fl - 96 h\n\u003Cbr \u002F> 对水蚤和其他水生无脊半数效应浓度（EC50） - 大型蚤 (水蚤) - > 1.5 mg\u002Fl - 48 h\n\u003Cbr \u002F> 椎动物的毒性\n\u003Cbr \u002F>\n\u003Cb>12.2 持久性和降解性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.3 潜在的生物累积性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.4 土壤中的迁移性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.5 PBT 和 vPvB的结果评价\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.6 其它不良影响\u003C\u002Fb>\n\u003Cbr \u002F> 对水生生物有毒。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块13. 废弃处置\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>13.1 废物处理方法\u003C\u002Fb>\n\u003Cbr \u002F> 产品\n\u003Cbr \u002F> 与易燃溶剂相溶或者相混合，在备有燃烧后处理和洗刷作用的化学焚化炉中燃烧\n\u003Cbr \u002F> 受污染的容器和包装\n\u003Cbr \u002F> 按未用产品处置。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块14. 运输信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 欧洲陆运危规: 3077国际海运危规: 3077国际空运危规: 3077\n\u003Cbr \u002F>\n\u003Cb>14.2 联合国运输名称\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Celecoxib)\n\u003Cbr \u002F> 国际海运危规: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Celecoxib)\n\u003Cbr \u002F> 国际空运危规: Environmentally hazardous substance, solid, n.o.s. (Celecoxib)\n\u003Cbr \u002F>\n\u003Cb>14.3 运输危险类别\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: 9国际海运危规: 9国际空运危规: 9\n\u003Cbr \u002F>\n\u003Cb>14.4 包裹组\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: III国际海运危规: III国际空运危规: III\n\u003Cbr \u002F>\n\u003Cb>14.5 环境危险\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: 是国际海运危规国际空运危规: 是\n\u003Cbr \u002F> 海洋污染物（是\u002F否）: 是\n\u003Cbr \u002F>\n\u003Cb>14.6 对使用者的特别提醒\u003C\u002Fb>\n\u003Cbr \u002F> 进一步信息\n\u003Cbr \u002F> 危险品独立包装,液体5升以上或固体5公斤以上,每个独立包装外和独立内包装合并后的外包装上都必须有EHS\n\u003Cbr \u002F> 标识 (根据欧洲 ADR 法规 2.2.9.1.10, IMDG 法规 2.10.3),\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块 15 - 法规信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[356,362,368,374,380,386],{"slug":357,"cid":358,"name":359,"nameZh":360,"cas":361},"785888480654790656","J-1958131-8","Rabeprazole sodium","雷贝拉唑钠","117976-90-6",{"slug":363,"cid":364,"name":365,"nameZh":366,"cas":367},"785897800498941952","J-47960-6","Solvent Red 24","苏丹Ⅳ","85-83-6",{"slug":369,"cid":370,"name":371,"nameZh":372,"cas":373},"785895822460981248","J-42947-6","D-(+)-Trehalose dihydrate","D-(+)-海藻糖二水合物","6138-23-4",{"slug":375,"cid":376,"name":377,"nameZh":378,"cas":379},"785896769497075712","J-45303-5","Cholecalciferol","维生素D3","67-97-0",{"slug":381,"cid":382,"name":383,"nameZh":384,"cas":385},"785884051318771712","J-1114131-2","Alizarin Complexone","茜素络合指示剂","3952-78-1",{"slug":387,"cid":388,"name":389,"nameZh":390,"cas":391},"785898743068102656","J-1365189-3","Esomeprazole calcium","埃索美拉唑钙","161796-85-6",1792661817811,"zh-CN",[]]