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溶解性：未确定",{"pictogram":240,"signal":241,"hazards":242},"Irritant","Warning",[243],"H302 — Harmful if swallowed \u002F 吞咽有害",[],[246,249,252,255,258,261,264,267],{"key":247,"value":248},"描述","Irinotecan hydrochloride是一种水溶性的拓扑异构酶I抑制剂,主要用于治疗结肠癌和直肠癌。",{"key":250,"value":251},"相关类别","信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\n细胞周期\u002FDNA损伤\n>>\n拓扑异构酶\n研究领域\n>>\n癌症",{"key":253,"value":254},"靶点","Topoisomerase I",{"key":256,"value":257},"体外研究","伊立替康盐酸盐是拓扑异构酶I抑制剂。伊立替康抑制LoVo和HT-29细胞的生长,IC50分别为15.8±5.1和5.17±1.4μM,并且在LoVo和HT-29细胞中诱导相似量的可切割复合物[2]。伊立替康抑制人脐静脉内皮细胞(HUVEC)的增殖,IC50为1.3μM[3]。",{"key":259,"value":260},"体内研究","伊立替康(CPT-11,5mg\u002Fkg)在大鼠中连续两周每天通过肿瘤内注射显着抑制肿瘤的生长,并且这种效果也通过渗透微型泵连续腹膜内输注进入小鼠而发生。然而,伊立替康(10 mg\u002Fkg)对ip的生长没有影响[1]。伊立替康(CPT-11,100-300mg\u002Fkg,ip)显然在第21天抑制无胸腺雌性小鼠中HT-29异种移植物的肿瘤生长。两组伊立替康(125mg\u002Fkg)加TSP-1(10mg)\u002Fkg \u002F天或伊立替康(150 mg\u002Fkg)联合使用TSP-1(每天20 mg\u002Fkg)几乎同样有效,分别抑制肿瘤生长84％和89％,两者均比单独使用伊立替康更有效剂量为250和300毫克\u002F千克[3]。",{"key":262,"value":263},"细胞实验","将指数生长的细胞接种在20cm 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Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor. J Neurooncol. 2002 Feb;56(3):219-26.\n[2].\nPavillard V, et al. Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines. Cancer Chemother Pharmacol. 2002 Apr;49(4):329-35. Epub 2002 Jan 30.\n[3].\nAllegrini G, et al. Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice. Cancer Chemother Pharmacol. 2004 Mar;53(3):261-6. 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5.",[271,277,283,289,295,301],{"slug":272,"cid":273,"name":274,"nameZh":274,"cas":275,"imgSvg":276},"785889539120959500","J-27963-7","4-哌啶基哌啶","4897-50-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F398\u002F4897-50-1.svg",{"slug":278,"cid":279,"name":280,"nameZh":280,"cas":281,"imgSvg":282},"785893654823702500","J-1323512-7","7-乙基-10羟基喜树碱","86639-52-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F142\u002F86639-52-3.svg",{"slug":284,"cid":285,"name":286,"nameZh":286,"cas":287,"imgSvg":288},"785893478084120600","J-35243-7","伊立替康","97682-44-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F155\u002F97682-44-5.svg",{"slug":290,"cid":291,"name":292,"nameZh":292,"cas":293,"imgSvg":294},"785892355071807500","J-1492136-6","[1,4']联哌啶-1'-甲酰氯","103816-19-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F028\u002F103816-19-9.svg",{"slug":296,"cid":297,"name":298,"nameZh":298,"cas":299,"imgSvg":300},"785892948490326000","J-1962135-7","(S)-4-乙基-4-羟基-7...","110351-94-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F225\u002F110351-94-5.svg",{"slug":302,"cid":303,"name":304,"nameZh":304,"cas":305,"imgSvg":306},"785892762363891700","J-33600-2","3-氟苯甲醛","456-48-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F035\u002F456-48-4.svg",[308,309],{"slug":278,"cid":279,"name":280,"nameZh":280,"cas":281,"imgSvg":282},{"slug":310,"cid":311,"name":175,"nameZh":175,"cas":312,"imgSvg":313},"785875572671647700","J-1971771-3","136572-09-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F100\u002F136572-09-3.svg",[],[316,319,321,324,327,330,333,336],{"key":317,"value":318},"符号","GHS07",{"key":320,"value":241},"信号词",{"key":322,"value":323},"危害声明","H302",{"key":325,"value":326},"个人防护装备","dust mask type N95 (US);Eyeshields;Gloves",{"key":328,"value":329},"危害码 (欧洲)","Xn",{"key":331,"value":332},"风险声明 (欧洲)","R22",{"key":334,"value":335},"危险品运输编码","NONH for all modes of transport",{"key":337,"value":338},"RTECS号","DW1060750","\u003Ctd>\n\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F100286-90-6_118546.html#duXinDiv\">盐酸依立替康毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Cp>1. 7-乙基喜树碱的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入喜树碱(camptothecin)1.00g(2.9mmol)、含FeSO4·7H2O 0.30g(1.1mmol)和丙醛2ml的100ml水混合液,于冰浴冷却下滴入浓H2SO4 1ml(搅拌下).再在搅拌下加入30%H2O2 0.72ml(6.4mmol).加毕,于室温下再搅拌反应3h.加水100ml稀释,用氯仿(100ml×3)提取.有机层用无水MgSO4干燥,过滤,滤液浓缩,剩余物用硅胶柱色谱纯化,用2%甲醇\u002F氯仿洗脱.目的组分流出液经后处理,得淡黄色针状结晶7-乙基喜树碱0.84g,mp258~261ºC,收率77%.\u003C\u002Fp>\u003Cp>2. 7-乙基喜树碱-1-氧的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入7-乙基喜树碱3.00g(7.97mmol)、乙酸800ml和30%H2O2 50ml,搅拌加热至70~80ºC,在该温度下搅拌反应3.5h.于45~55ºC将反应液浓缩至原体积的1\u002F3,剩余物倒入冰水3000ml中,析出沉淀,过滤,滤饼经重结晶纯化后,得橙黄色针状结晶7-乙基喜树碱-1-氧2.4g,mp255ºC,收率78%.\u003C\u002Fp>\u003Cp>3. 7-乙基-10-羟基喜树碱的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入7-乙基喜树碱-1-氧1.00g(2.6mmol)和1mol\u002FLH2SO4 2.6ml溶于二氧六环1000ml的溶液,用N2鼓泡换气20min.在搅拌下#用带有硅硼玻璃(Pyrex,派瑞克斯)滤片的高压汞灯(450W,Usio,UM-452)照射30min.将反应液浓缩至干,剩余物用10%甲醇\u002F氯仿50ml溶解.用水500ml洗涤,有机层和无机层都通过一装有硅藻土的柱子,二相中的不溶物均被吸附其上,然后用10%甲醇\u002F氯仿(200ml×3)洗脱.洗脱液浓缩后,剩余物用甲醇洗后重结晶,得淡黄色针状结晶7-乙基-10-羟基喜树碱0.5g,收率49%,mp216ºC.\u003C\u002Fp>\u003Cp>4. 7-乙基-10-氯甲酰氧基喜树碱的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入7-乙基-10-羟基喜树碱5.00g(12.8mmol)、二氧六环(干燥的)4000ml和三乙胺50ml,于室温,搅拌下通入光气(由3.75ml双光气作用于活性炭所产生),用TLC跟踪,确认原料消耗尽,定反应终点.继续搅拌反应1h. 过滤,滤液减压浓缩至干.剩余物用丙酮浸渍后过滤,抽干,得无色粉状物5.2g,收率90%.\u003C\u002Fp>\u003Cp>5. 伊立替康的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入7-乙基-10-氯甲酰氧基喜树碱3.0g(6.6mmol0、二氯甲烷50ml和甲醇150ml、吡啶15ml,搅拌溶解,于室温搅拌下滴加4-哌啶基哌啶3.3g(19.6mmol)的二氯甲烷溶液.加毕,在室温下继续搅拌反应15h.减压浓缩至干,剩余物溶于二氯甲烷,用NaHCO3溶液洗涤,无水MgSO4干燥.过滤,滤液减压浓缩,剩余物经硅胶柱色谱纯化,4%甲醇\u002F二氯甲烷洗脱. 得淡黄色粉状物伊立替康3.09g,收率79.8%,mp222~223ºC.\u003C\u002Fp>\u003Cp>6. 盐酸伊立替康的合成\u003C\u002Fp>\u003Cp>在反应瓶中加入伊立替康2g(3.4mmol),加乙醇适量后,搅拌微加热溶解,控制20ºC通HCl气体至溶液呈酸性(pH4), 减压浓缩至干,剩余用水重结晶得盐酸伊立替康1.5g,mp256.5ºC,收率65.2%.\u003C\u002Fp>\u003Cp>\u003C\u002Fp>","\u003Ctd>\n\n\n\u003Cstrong>模块1. 化学品\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>1.1 产品标识符\u003C\u002Fb>\n\u003Cbr \u002F> : Irinotecan 盐酸盐\n\u003Cbr \u002F> 产品名称\n\u003Cbr \u002F>\n\u003Cb>1.2 鉴别的其他方法\u003C\u002Fb>\n\u003Cbr \u002F> [1,4′-Bipiperidine]-1′-carboxylic acid\n\u003Cbr \u002F> (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl\n\u003Cbr \u002F> ester\n\u003Cbr \u002F> CPT-11\n\u003Cbr \u002F>\n\u003Cb>1.3 有关的确定了的物质或混合物的用途和建议不适合的用途\u003C\u002Fb>\n\u003Cbr \u002F> 仅用于研发。不作为药品、家庭或其它用途。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>2.1 GHS-分类\u003C\u002Fb>\n\u003Cbr \u002F> 急性毒性, 经口 (类别 4)\n\u003Cbr \u002F>\n\u003Cb>2.2 GHS 标记要素，包括预防性的陈述\u003C\u002Fb>\n\u003Cbr \u002F> 象形图\n\u003Cbr \u002F> 警示词警告\n\u003Cbr \u002F> 危险申明\n\u003Cbr \u002F> H302吞咽有害。\n\u003Cbr \u002F> 警告申明\n\u003Cbr \u002F> 预防措施\n\u003Cbr \u002F> P264操作后彻底清洁皮肤。\n\u003Cbr \u002F> P270使用本产品时不要进食、饮水或吸烟。\n\u003Cbr \u002F> 事故响应\n\u003Cbr \u002F> P301 + P312如果吞咽并觉不适: 立即呼叫解毒中心或就医。\n\u003Cbr \u002F> P330漱口。\n\u003Cbr \u002F> 废弃处置\n\u003Cbr \u002F> P501将内容物\u002F 容器处理到得到批准的废物处理厂。\n\u003Cbr \u002F>\n\u003Cb>2.3 其它危害物 - 无\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>3.1 物 质\u003C\u002Fb>\n\u003Cbr \u002F> : [1,4′-Bipiperidine]-1′-carboxylic acid\n\u003Cbr \u002F> 别名\n\u003Cbr \u002F> (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-\n\u003Cbr \u002F> pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester\n\u003Cbr \u002F> CPT-11\n\u003Cbr \u002F> : C33H38N4O6 · HCl\n\u003Cbr \u002F> 分子式\n\u003Cbr \u002F> : 623.14 g\u002Fmol\n\u003Cbr \u002F> 分子量\n\u003Cbr \u002F> 组分浓度或浓度范围\n\u003Cbr \u002F> Irinotecan hydrochloride\n\u003Cbr \u002F> <=100%\n\u003Cbr \u002F> 化学文摘登记号(CAS100286-90-6\n\u003Cbr \u002F> No.)\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>4.1 必要的急救措施描述\u003C\u002Fb>\n\u003Cbr \u002F> 一般的建议\n\u003Cbr \u002F> 请教医生。 向到现场的医生出示此安全技术说明书。\n\u003Cbr \u002F> 吸入\n\u003Cbr \u002F> 如果吸入,请将患者移到新鲜空气处。 如呼吸停止,进行人工呼吸。 请教医生。\n\u003Cbr \u002F> 皮肤接触\n\u003Cbr \u002F> 用肥皂和大量的水冲洗。 请教医生。\n\u003Cbr \u002F> 眼睛接触\n\u003Cbr \u002F> 用水冲洗眼睛作为预防措施。\n\u003Cbr \u002F> 食入\n\u003Cbr \u002F> 切勿给失去知觉者通过口喂任何东西。 用水漱口。 请教医生。\n\u003Cbr \u002F>\n\u003Cb>4.2 主要症状和影响，急性和迟发效应\u003C\u002Fb>\n\u003Cbr \u002F> 动物试验显示有毒。, 据我们所知，此化学，物理和毒性性质尚未经完整的研究。\n\u003Cbr \u002F>\n\u003Cb>4.3 及时的医疗处理和所需的特殊处理的说明和指示\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块5. 消防措施\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>5.1 灭火介质\u003C\u002Fb>\n\u003Cbr \u002F> 灭火方法及灭火剂\n\u003Cbr \u002F> 用水雾,抗乙醇泡沫,干粉或二氧化碳灭火。\n\u003Cbr \u002F>\n\u003Cb>5.2 源于此物质或混合物的特别的危害\u003C\u002Fb>\n\u003Cbr \u002F> 碳氧化物, 氮氧化物, 氯化氢气体\n\u003Cbr \u002F>\n\u003Cb>5.3 给消防员的建议\u003C\u002Fb>\n\u003Cbr \u002F> 如必要的话,戴自给式呼吸器去救火。\n\u003Cbr \u002F>\n\u003Cb>5.4 进一步信息\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄露应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>6.1 作业人员防护措施、防护装备和应急处置程序\u003C\u002Fb>\n\u003Cbr \u002F> 使用个人防护用品。 避免粉尘生成。 避免吸入蒸气、烟雾或气体。 保证充分的通风。 避免吸入粉尘。\n\u003Cbr \u002F>\n\u003Cb>6.2 环境保护措施\u003C\u002Fb>\n\u003Cbr \u002F> 不要让产品进入下水道。\n\u003Cbr \u002F>\n\u003Cb>6.3 泄漏化学品的收容、清除方法及所使用的处置材料\u003C\u002Fb>\n\u003Cbr \u002F> 收集和处置时不要产生粉尘。 扫掉和铲掉。 放入合适的封闭的容器中待处理。\n\u003Cbr \u002F>\n\u003Cb>6.4 参考其他部分\u003C\u002Fb>\n\u003Cbr \u002F> 丢弃处理请参阅第13节。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块7. 操作处置与储存\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>7.1 安全操作的注意事项\u003C\u002Fb>\n\u003Cbr \u002F> 避免接触皮肤和眼睛。 避免形成粉尘和气溶胶。\n\u003Cbr \u002F> 在有粉尘生成的地方,提供合适的排风设备。\n\u003Cbr \u002F>\n\u003Cb>7.2 安全储存的条件,包括任何不兼容性\u003C\u002Fb>\n\u003Cbr \u002F> 贮存在阴凉处。 使容器保持密闭，储存在干燥通风处。\n\u003Cbr \u002F> 建议的贮存温度： 2 - 8 °C\n\u003Cbr \u002F>\n\u003Cb>7.3 特定用途\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>8.1 容许浓度\u003C\u002Fb>\n\u003Cbr \u002F> 最高容许浓度\n\u003Cbr \u002F> 没有已知的国家规定的暴露极限。\n\u003Cbr \u002F>\n\u003Cb>8.2 暴露控制\u003C\u002Fb>\n\u003Cbr \u002F> 适当的技术控制\n\u003Cbr \u002F> 根据良好的工业卫生和安全规范进行操作。 休息前和工作结束时洗手。\n\u003Cbr \u002F> 个体防护设备\n\u003Cbr \u002F> 眼\u002F面保护\n\u003Cbr \u002F> 带有防护边罩的安全眼镜符合 EN166要求请使用经官方标准如NIOSH (美国) 或 EN 166(欧盟)\n\u003Cbr \u002F> 检测与批准的设备防护眼部。\n\u003Cbr \u002F> 皮肤保护\n\u003Cbr \u002F> 戴手套取 手套在使用前必须受检查。\n\u003Cbr \u002F> 请使用合适的方法脱除手套(不要接触手套外部表面),避免任何皮肤部位接触此产品.\n\u003Cbr \u002F> 使用后请将被污染过的手套根据相关法律法规和有效的实验室规章程序谨慎处理. 请清洗并吹干双手\n\u003Cbr \u002F> 所选择的保护手套必须符合EU的89\u002F686\u002FEEC规定和从它衍生出来的EN 376标准。\n\u003Cbr \u002F> 完全接触\n\u003Cbr \u002F> 物料: 丁腈橡胶\n\u003Cbr \u002F> 最小的层厚度 0.11 mm\n\u003Cbr \u002F> 溶剂渗透时间: 480 min\n\u003Cbr \u002F> 测试过的物质Dermatril® (KCL 740 \u002F Z677272, 规格 M)\n\u003Cbr \u002F> 飞溅保护\n\u003Cbr \u002F> 物料: 丁腈橡胶\n\u003Cbr \u002F> 最小的层厚度 0.11 mm\n\u003Cbr \u002F> 溶剂渗透时间: 480 min\n\u003Cbr \u002F> 测试过的物质Dermatril® (KCL 740 \u002F Z677272, 规格 M)\n\u003Cbr \u002F> 测试方法 EN374\n\u003Cbr \u002F> 如果以溶剂形式应用或与其它物质混合应用，或在不同于EN\n\u003Cbr \u002F> 374规定的条件下应用，请与EC批准的手套的供应商联系。\n\u003Cbr \u002F> 这个推荐只是建议性的,并且务必让熟悉我们客户计划使用的特定情况的工业卫生学专家评估确认才可.\n\u003Cbr \u002F> 这不应该解释为在提供对任何特定使用情况方法的批准.\n\u003Cbr \u002F> 身体保护\n\u003Cbr \u002F> 全套防化学试剂工作服, 防护设备的类型必须根据特定工作场所中的危险物的浓度和数量来选择。\n\u003Cbr \u002F> 呼吸系统防护\n\u003Cbr \u002F> 如须暴露于有害环境中,请使用P95型(美国)或P1型(欧盟 英国\n\u003Cbr \u002F> 143)防微粒呼吸器。如需更高级别防护,请使用OV\u002FAG\u002FP99型(美国)或ABEK-P2型 (欧盟 英国 143)\n\u003Cbr \u002F> 防毒罐。\n\u003Cbr \u002F> 呼吸器使用经过测试并通过政府标准如NIOSH（US）或CEN（EU）的呼吸器和零件。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>9.1 基本的理化特性的信息\u003C\u002Fb>\n\u003Cbr \u002F> a) 外观与性状\n\u003Cbr \u002F> 形状: 固体\n\u003Cbr \u002F> b) 气味\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> c) 气味阈值\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> d) pH值\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> e) 熔点\u002F凝固点\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> f) 沸点、初沸点和沸程\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> g) 闪点\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> h) 蒸发速率\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> i) 易燃性(固体,气体)\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> j) 高的\u002F低的燃烧性或爆炸性限度 无数据资料\n\u003Cbr \u002F> k) 蒸气压\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> l) 蒸汽密度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> m) 密度\u002F相对密度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> n) 水溶性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> o) n-辛醇\u002F水分配系数\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> p) 自燃温度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> q) 分解温度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> r) 粘度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块10. 稳定性和反应活性\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>10.1 反应性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.2 稳定性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.3 危险反应\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.4 应避免的条件\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.5 不相容的物质\u003C\u002Fb>\n\u003Cbr \u002F> 强氧化剂\n\u003Cbr \u002F>\n\u003Cb>10.6 危险的分解产物\u003C\u002Fb>\n\u003Cbr \u002F> 其它分解产物 - 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块11. 毒理学资料\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>11.1 毒理学影响的信息\u003C\u002Fb>\n\u003Cbr \u002F> 急性毒性\n\u003Cbr \u002F> 半数致死剂量 (LD50) 经口 - 大鼠 - 867 mg\u002Fkg\n\u003Cbr \u002F> 备注: 感觉器官和特殊感觉（鼻、眼、耳和味觉）：眼：其他。 行为的：抽搐或对癫痫阈值的影响。\n\u003Cbr \u002F> 肺，胸，或者呼吸系统：其他变化\n\u003Cbr \u002F> 半数致死剂量 (LD50) 静脉内的 - 大鼠 - 83.6 mg\u002Fkg\n\u003Cbr \u002F> 半数致死剂量 (LD50) 静脉内的 - 小鼠 - 132 mg\u002Fkg\n\u003Cbr \u002F> 备注: 感觉器官和特殊感觉（鼻、眼、耳和味觉）：眼：其他。 行为的：抽搐或对癫痫阈值的影响。\n\u003Cbr \u002F> 肺，胸，或者呼吸系统：其他变化\n\u003Cbr \u002F> 皮肤刺激或腐蚀\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 眼睛刺激或腐蚀\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 呼吸道或皮肤过敏\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 生殖细胞致突变性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 致癌性\n\u003Cbr \u002F> IARC:\n\u003Cbr \u002F> 此产品中没有大于或等于 0。1%含量的组分被 IARC鉴别为可能的或肯定的人类致癌物。\n\u003Cbr \u002F> 生殖毒性\n\u003Cbr \u002F> 婴儿可能出现先天性畸形和畸形的危险\n\u003Cbr \u002F> 特异性靶器官系统毒性（一次接触）\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 特异性靶器官系统毒性（反复接触）\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 吸入危险\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 潜在的健康影响\n\u003Cbr \u002F> 吸入吸入可能有害。 可能引起呼吸道刺激。\n\u003Cbr \u002F> 摄入误吞对人体有害。\n\u003Cbr \u002F> 皮肤通过皮肤吸收可能有害。 可能引起皮肤刺激。\n\u003Cbr \u002F> 眼睛可能引起眼睛刺激。\n\u003Cbr \u002F> 接触后的征兆和症状\n\u003Cbr \u002F> 动物试验显示有毒。, 据我们所知，此化学，物理和毒性性质尚未经完整的研究。\n\u003Cbr \u002F> 附加说明\n\u003Cbr \u002F> 化学物质毒性作用登记: DW1061000\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学资料\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>12.1 生态毒性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.2 持久性和降解性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.3 潜在的生物累积性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.4 土壤中的迁移性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.5 PBT 和 vPvB的结果评价\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.6 其它不良影响\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块13. 废弃处置\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>13.1 废物处理方法\u003C\u002Fb>\n\u003Cbr \u002F> 产品\n\u003Cbr \u002F> 将剩余的和不可回收的溶液交给有许可证的公司处理。\n\u003Cbr \u002F> 与易燃溶剂相溶或者相混合，在备有燃烧后处理和洗刷作用的化学焚化炉中燃烧\n\u003Cbr \u002F> 受污染的容器和包装\n\u003Cbr \u002F> 按未用产品处置。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块14. 运输信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>14.1 联合国危险货物编号\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: -国际海运危规: -国际空运危规: -\n\u003Cbr \u002F>\n\u003Cb>14.2 联合国运输名称\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: 非危险货物\n\u003Cbr \u002F> 国际海运危规: 非危险货物\n\u003Cbr \u002F> 国际空运危规: 非危险货物\n\u003Cbr \u002F>\n\u003Cb>14.3 运输危险类别\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: -国际海运危规: -国际空运危规: -\n\u003Cbr \u002F>\n\u003Cb>14.4 包裹组\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: -国际海运危规: -国际空运危规: -\n\u003Cbr \u002F>\n\u003Cb>14.5 环境危险\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: 否国际海运危规国际空运危规: 否\n\u003Cbr \u002F> 海洋污染物（是\u002F否）: 否\n\u003Cbr \u002F>\n\u003Cb>14.6 对使用者的特别提醒\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块 15 - 法规信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\u003Cbr \u002F>\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[345,351,357,363,369,375],{"slug":346,"cid":347,"name":348,"nameZh":349,"cas":350},"785892465260367872","J-1960878-9","Octenidine dihydrochloride","盐酸奥替尼啶","70775-75-6",{"slug":352,"cid":353,"name":354,"nameZh":355,"cas":356},"785882701432360960","J-5397-4","Lutetium(III) trifluoromethanesulfonate","三氟甲磺酸镥(III)","126857-69-0",{"slug":358,"cid":359,"name":360,"nameZh":361,"cas":362},"785872198274387968","J-1320750-8","Ferric glycerophosphate","甘油磷酸铁","1301-70-8",{"slug":364,"cid":365,"name":366,"nameZh":367,"cas":368},"785883988035112960","J-22448-0","Ytterbium(III) trifluoromethanesulfonate","三氟甲磺酸镱","54761-04-5",{"slug":370,"cid":371,"name":372,"nameZh":373,"cas":374},"785897519728037888","J-1521957-0","Hydrotalcite","铝碳酸镁","12304-65-3",{"slug":376,"cid":377,"name":378,"nameZh":379,"cas":380},"785891560863567872","J-30247-6","Lead(II) hexacyanoferrate(II)","六氰合铁酸铅(II)","14402-61-0",1792611390746,"zh-CN",[]]