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氢键供体数量：3\n3、 氢键受体数量：5\n4、 可旋转化学键数量：1\n5、 互变异构体数量：42\n6、 拓扑分子极性表面积（TPSA）：87\n7、 重原子数量：20\n8、 表面电荷：0\n9、 复杂度：363\n10、同位素原子数量：0\n11、确定原子立构中心数量：1\n12、不确定原子立构中心数量：0\n13、确定化学键立构中心数量：0\n14、不确定化学键立构中心数量：0\n15、共价键单元数量：1",{"label":241,"labelZh":241,"value":242},"更多","1. 性状：米色或棕色粉末\n2. 密度（g\u002FmL,25℃）：未确定\n3. 相对蒸汽密度（g\u002FmL,空气=1）：未确定\n4. 熔点（ºC）：247-250\n5. 沸点（ºC,常压）：未确定\n6. 沸点（ºC,11mmHg）：未确定\n7. 折射率(n20\u002FD)：未确定\n8. 闪点（ºF）：未确定\n9. 比旋光度（º）：未确定\n10. 自燃点或引燃温度（ºC）：未确定\n11. 蒸气压（mmHg,25ºC）：未确定\n12. 饱和蒸气压（kPa,25ºC）：未确定\n13. 燃烧热（KJ\u002Fmol）：未确定\n14. 临界温度（ºC）：未确定\n15. 临界压力（KPa）：未确定\n16. 油水（辛醇\u002F水）分配系数的对数值：未确定\n17. 爆炸上限（%,V\u002FV）：未确定\n18. 爆炸下限（%,V\u002FV）：未确定\n19. 溶解性：未确定",null,[],[246,249,252,255,258,261,264],{"key":247,"value":248},"描述","Naringenin是葡萄柚中主要的黄烷酮; 显示出强烈的抗炎和抗氧化活性。",{"key":250,"value":251},"相关类别","研究领域\n>>\n癌症\n天然产物\n>>\n黄酮类化合物",{"key":253,"value":254},"体外研究","柚皮素显示抑制HepG2细胞的增殖,部分原因是细胞周期的G0\u002FG1期和G2\u002FM期细胞积聚。已经证明柚皮素可以诱导细胞凋亡,这可以通过细胞核损伤和凋亡细胞比例增加来证明。 Naringenin触发线粒体介导的细胞凋亡途径,如Bax\u002FBcl-2比例增加,随后细胞色素C释放和caspase-3顺序激活所示[1]。柚皮素暴露显着降低A431细胞的细胞活力,同时以剂量依赖性方式伴随核浓缩和DNA片段化的增加。细胞周期研究表明,柚皮素诱导细胞周期G0\u002FG1期细胞周期停滞,caspase-3分析显示caspase-3活性呈剂量依赖性增加,导致细胞凋亡[2]。",{"key":256,"value":257},"体内研究","柚皮素补充剂导致血浆和肝脏中总甘油三酯和胆固醇的量显着减少。此外,柚皮素补充剂可降低宫旁脂肪组织中的肥胖和甘油三酯含量。柚皮素喂养的动物显示肝脏中PPARα蛋白表达显着增加。已知受PPARα调节的CPT-1和UCP2的表达通过柚皮素治疗显着增强[3]。柚皮素通过PPARγ辅激活因子1α\u002FPPARα介导的转录程序增加肝脏脂肪酸氧化。它通过减少空腹高胰岛素血症来预防甾醇调节元件结合蛋白1c介导的肝脏和肌肉脂肪生成。柚皮素可降低肝脏胆固醇和胆固醇酯的合成[4]。柚皮素以剂量依赖性方式抑制TNF-α诱导的VSMC增殖和迁移。机理研究表明,柚皮素可阻止ERK\u002FMAPK和Akt磷酸化,同时保持p38 MAPK和JNK不变。柚皮素还可以阻断TNF-α诱导的ROS生成[5]。",{"key":259,"value":260},"细胞实验","将柚皮素溶解在DMSO中并在细胞培养基中稀释。用PBS冲洗细胞并在含有各种浓度的柚皮素（50,100,150,200,250,300μM）的培养基中生长。溶剂DMSO处理的细胞用作对照。处理24小时后，除去培养基并用含有MTT的另一种培养基替换。使用MTT测定法测量细胞活力[1]。",{"key":262,"value":263},"动物实验","大鼠：制备半纯化的粉末饮食，用于浓度为柚皮素：0,0.003,0.006和0.012％的饮食。适应7天后，将大鼠分成四组中的一组，每组六只动物，并喂食半纯化的实验饮食6周。实验饮食含有16％脂肪，45.5％蔗糖和不同的柚皮素浓度（0,0.003,0.006或0.012％）（表1）。在研究期间，大鼠可随意获取食物和水。在整个实验过程中测量食物摄入量和体重[3]。小鼠：8至12周龄的小鼠随意喂食啮齿动物标准饮食或含有42％来自脂肪加胆固醇（0.05％wt \u002F wt）的卡路里的高脂肪饮食。柚皮素以1％或3％（wt \u002F wt）加入西方饮食中。 Ldlr  -  \u002F  - 小鼠喂养4周，C57BL \u002F 6J小鼠喂养30周。每天测量食物摄入量，每两周测量一次体重。在干预前将小鼠禁食6小时[4]。",{"key":265,"value":266},"参考文献","[1].\nArul D, et al. Naringenin (citrus flavonone) induces growth inhibition, cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. Pathol Oncol Res. 2013 Oct;19(4):763-70.\n[2].\nAhamad MS, et al. Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinomacell through ROS generation and cell cycle arrest. PLoS One. 2014 Oct 16;9(10):e110003.\n[3].\nCho KW, et al. Dietary naringenin increases hepatic peroxisome proliferators-activated receptor α proteinexpression and decreases plasma triglyceride and adiposity in rats. Eur J Nutr. 2011 Mar;50(2):81-8.\n[4].\nMulvihill EE, et al. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDLreceptor-null mice with diet-induced insulin resistance. Diabetes. 2009 Oct;58(10):2198-210.\n[5].\nChen S, et al. Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1. Food Chem Toxicol. 2012 Sep;50(9):3025-31.",[268,274,280,286,292],{"slug":269,"cid":270,"name":271,"nameZh":271,"cas":272,"imgSvg":273},"785880750581878800","J-17025-5","芹菜素; 芹黄素; 5,7,4...","520-36-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F209\u002F520-36-5.svg",{"slug":275,"cid":276,"name":277,"nameZh":277,"cas":278,"imgSvg":279},"785881209510039600","J-18391-2","2,4,6-三羟基苯甲醛","487-70-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F121\u002F487-70-7.svg",{"slug":281,"cid":282,"name":283,"nameZh":283,"cas":284,"imgSvg":285},"785876764361494500","J-1099016-6","4-(3-甲基-2-丁烯氧基)苯甲醛","28090-12-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F390\u002F28090-12-2.svg",{"slug":287,"cid":288,"name":289,"nameZh":289,"cas":290,"imgSvg":291},"785882362616483800","J-3354-5","柚皮苷","10236-47-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F379\u002F10236-47-2.svg",{"slug":293,"cid":294,"name":295,"nameZh":295,"cas":296,"imgSvg":297},"785882898350739500","J-6078-1","黄卡瓦胡椒素A; 2'- 羟基...","3420-72-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F090\u002F3420-72-2.svg",[299,305,311,317,323,329,335,341,347],{"slug":300,"cid":301,"name":302,"nameZh":302,"cas":303,"imgSvg":304},"785873514828664800","J-1971194-2","5,7-二羟基-3-(4-羟基...","107585-77-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F401\u002F107585-77-3.svg",{"slug":306,"cid":307,"name":308,"nameZh":308,"cas":309,"imgSvg":310},"785894546700505100","J-37940-3","根皮素","60-82-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F002\u002F60-82-2.svg",{"slug":312,"cid":313,"name":314,"nameZh":314,"cas":315,"imgSvg":316},"785894562861158400","J-38022-5","木犀草素; 3',4',5,7...","491-70-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F392\u002F491-70-3.svg",{"slug":318,"cid":319,"name":320,"nameZh":320,"cas":321,"imgSvg":322},"785891933196128300","J-1960146-7","5-羟基-4’,7-二甲氧基黄酮","5128-44-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F015\u002F5128-44-9.svg",{"slug":324,"cid":325,"name":326,"nameZh":326,"cas":327,"imgSvg":328},"785883243575513100","J-7641-8","1,1-二苯基-2-苦味酰肼","1707-75-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F006\u002F1707-75-1.svg",{"slug":330,"cid":331,"name":332,"nameZh":332,"cas":333,"imgSvg":334},"785872747669491700","J-977206-1","染料木素","446-72-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F457\u002F446-72-0.svg",{"slug":336,"cid":337,"name":338,"nameZh":338,"cas":339,"imgSvg":340},"785888445829484500","J-24918-4","黄烷酮","487-26-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F428\u002F487-26-3.svg",{"slug":342,"cid":343,"name":344,"nameZh":344,"cas":345,"imgSvg":346},"785894013222785000","J-1564-6","阿福豆苷","482-39-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F347\u002F482-39-3.svg",{"slug":348,"cid":349,"name":350,"nameZh":350,"cas":351,"imgSvg":352},"785896394593407000","J-1983194-5","异樱花亭","480-43-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F070\u002F480-43-3.svg",[354,357,360,363],{"key":355,"value":356},"海关编码","2932999099",{"key":358,"value":359},"中文概述","2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":361,"value":362},"申报要素","品名, 成分含量, 用途",{"key":364,"value":365},"Summary","2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[367,370,373,376,379],{"key":368,"value":369},"危害码 (欧洲)","Xn:Harmful",{"key":371,"value":372},"风险声明 (欧洲)","R22;R36\u002F37\u002F38",{"key":374,"value":375},"安全声明 (欧洲)","S26-S36-S37\u002F39",{"key":377,"value":378},"WGK德国","3",{"key":355,"value":356},"\u003Ctd>\n\n\u003Cp>\u003Cstrong>柚皮素； 4',5,7-三羟基黄烷酮生态学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp>对环境有危害，对水体有污染，禁止进入水体。  \u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F480-41-1_170636.html#duXinDiv\">柚皮素； 4',5,7-三羟基黄烷酮毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Ctd>\n\n\u003Ca href=\"\u002Fen\u002Fcas\u002F480-41-1_170636.html#MSDSDiv\">柚皮素； 4',5,7-三羟基黄烷酮MSDS英文版\u003C\u002Fa>\n\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[385,391,397,400,406,412],{"slug":386,"cid":387,"name":388,"nameZh":389,"cas":390},"785876366082969600","J-1973301-4","alpha-Arbutin","α-熊果苷","84380-01-8",{"slug":392,"cid":393,"name":394,"nameZh":395,"cas":396},"785882401510264832","J-3572-7","Aloe-emodin","芦荟大黄素","481-72-1",{"slug":398,"cid":307,"name":399,"nameZh":308,"cas":309},"785894546700505088","Phloretin",{"slug":401,"cid":402,"name":403,"nameZh":404,"cas":405},"785898538063106048","J-51103-0","Thorium dicarbide","二碳化钍","12071-31-7",{"slug":407,"cid":408,"name":409,"nameZh":410,"cas":411},"785882575020232704","J-4798-8","m-Methyl red","间甲基红","20691-84-3",{"slug":413,"cid":414,"name":415,"nameZh":416,"cas":417},"785894611636719616","J-38269-8","Methyl Red","甲基红","493-52-7",1792623014688,"zh-CN",[]]