[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1126289-9":171,"verified-suppliers-J-1126289-9":319},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":188,"ghs":211,"offers":212,"activity":213,"upstream":238,"downstream":275,"customs":276,"safetyRows":277,"updatedAt":278,"isProhibited":279,"related":280,"__ts":317,"__lang":318,"__slug":173},"785881572711600128","J-1126289-9","\u002Fimages\u002Fchem_structures_svg\u002F077\u002F701977-09-5.svg","泰伦那班","701977-09-5","C27H25ClF3N3O2","515.95500","organic","有机化合物","Organic Compounds",[],[184,185,186,187],"N-[(1S,2S)-3-(4-氯苯基)-2-(3-氰基苯基)-1-甲基丙基]-2-甲基-2-[(5-(三氟甲基)吡啶-2-基)氧基]丙酰胺","Taranabant游离态","化合物 T13080L","MK 0364",[189,193,197,201,204,207],{"label":190,"labelZh":190,"value":191,"prop":192},"Boiling Point","634.2ºC at 760 mmHg","boilingPoint",{"label":194,"labelZh":194,"value":195,"prop":196},"Density","1.3","density",{"label":198,"labelZh":199,"value":200},"Exact Mass","精确质量","515.15900",{"label":202,"labelZh":202,"value":203},"PSA","75.01000",{"label":205,"labelZh":205,"value":206},"LogP","6.70498",{"label":208,"labelZh":209,"value":210},"Storage Conditions","储存条件","2-8℃",null,[],[214,217,220,223,226,229,232,235],{"key":215,"value":216},"描述","Taranabant 是一种有效的选择性的 cannabinoid 1 (CB1) 受体反向激动剂,抑制结合和多种激动剂的功能活性,作用于人 CB1R,Ki 为 0.13 nM。",{"key":218,"value":219},"相关类别","信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\n大麻素受体\n研究领域\n>>\n代谢疾病",{"key":221,"value":222},"靶点","IC50: 0.3 nM (hCB1R), 0.4 nM (rCB1R)[1] Ki: 0.13 nM (hCB1R), 0.27 nM (rCB1R)[1]",{"key":224,"value":225},"体外研究","Taranabant(MK-0364)与人或大鼠CB1R结合,IC50分别为0.3和0.4nM,分别对应于Ki值0.13和0.27nM。 Taranabant分别与人或大鼠CB2R结合,IC50值分别为290和470nM,分别对应于Ki值170和310nM。 CB1R与CB2R的选择性比率约为1000倍[1]。 Taranabant(MK-0364)是一种新型的非环状大麻素-1受体反向激动剂,用于治疗肥胖症。 Taranabant对取代酰胺的CB1R和CB2R的IC50分别为0.3±0.1nM和290±60nM。 Taranabant是一种CB1R反向激动剂,具有最小的共价蛋白结合潜力。 Taranabant是一种特别有效和选择性(比CB2高900倍)的CB1R反向激动剂,其亲和力比原始铅提高了500倍。在环AMP产生的功能测定中,Taranabant被确定为反向激动剂(EC50 = 2.4±1.4nM)[2]。",{"key":227,"value":228},"体内研究","Taranabant(MK-0364)剂量依赖性地抑制C57BL\u002F6N小鼠的2小时和过夜食物摄入以及体重过夜增加。在1和3 mg\u002Fkg剂量(po)下,Taranabant显着抑制2小时食物摄入量(分别减少36％和69％;分别为P \u003C0.05和P \u003C0.00001)和过夜食物摄入量(13和40)分别减少％; P \u003C0.05和P \u003C0.00001)以及体重过夜增加(分别减少48和165％;分别为P \u003C0.01和P \u003C0.00001)。 Taranabant剂量依赖性地抑制食物摄入和体重增加,在饮食诱导的肥胖(DIO)大鼠中急性最小有效剂量为1 mg\u002Fkg [1]。 Taranabant(MK-0364)在三个物种中具有良好的药代动力学特征(大鼠,1mg\u002Fkg静脉注射,2mg\u002Fkg po,F = 74％,t1\u002F2 = 2.7h;狗,0.2mg\u002Fkg静脉注射,0.4 mg\u002Fkg po,F = 31％; t1\u002F2 = 14 h;恒河猴,0.2 mg\u002Fkg iv,0.4 mg\u002Fkg po,F = 31％,t1\u002F2 = 3.6 h)和良好的大脑暴露(1静脉注射mg\u002Fkg,脑和血浆浓度分别为0.11和0.18μM(1小时)[2]。",{"key":230,"value":231},"激酶实验","通过将各种浓度的Taranabant（MK-0364）与0.5nM [3H] CP55,940,1.5μg重组人CB1R-CHO膜（或0.1μg人CB2R-CHO膜）在50mM Tris-中孵育来进行结合测定。 HCl，pH7.4,5mM MgCl 2,2.5mM EDTA，0.5mg \u002F mL无脂肪酸的牛血清白蛋白（BSA），1x蛋白酶抑制剂混合物和1％DMSO。在37℃温育1小时后，通过过滤终止反应，并通过洗涤滤板将结合的放射性配体与游离放射性配体分离。特异性结合的放射性标记总量约为总加入的放射性标记的10％。通过非线性曲线拟合计算抑制性IC 50值，然后计算Ki值。重组人CB1R-CHO膜中的CB1R密度（Bmax = 5pmol \u002F mg，基于[3H] CP 55,940结合）与大鼠脑膜（3-5pmol \u002F mg）接近[1]。",{"key":233,"value":234},"动物实验","小鼠[1]使用雄性C57BL \u002F 6N野生型小鼠。将MK-0364溶解或分散（用超声处理）作为0.225％甲基纤维素\u002F 10％吐温80水溶液中的细均匀悬浮液，用于随后口服给药小鼠。称重所有小鼠，并且在光暗期开始前约30分钟通过口服管饲法给予雄性小鼠载体（0.225％甲基纤维素\u002F 10％吐温80水溶液）或Taranabant（1或3mg \u002F kg）。周期（每组n = 12，年龄23周，平均体重34.14±0.53g）。在给药后，在黑暗阶段随意喂食小鼠。在黑暗阶段开始前5分钟，在笼子的食物漏斗中提供预先称重的高度可口的中高脂肪饮食（来自蔗糖的25％千卡，来自脂肪的32％千卡，4.41千卡\u002F克）的等分试样。在光循环的暗相开始后2小时和18小时称重光循环并称重。此外，在光周期的暗期开始后18小时称重所有小鼠。该研究采用交叉设计，即首先给予载体和1-mk \u002F kg组。在4天洗脱后，先前的载体组给予3mg \u002F kg Taranabant，并且先前的1mg \u002F kg组给予载体。大鼠[1]对于急性实验，将雄性Sprague-Dawley DIO大鼠随机分组（n = 6只大鼠\u002F组）用于化合物和媒介物给药。给药后17小时称重大鼠，以确定对过夜体重增加的影响。 Taranabant在黑暗周期（下午3:00）开始前1小时口服给予DIO大鼠0.3,1和3mg \u002F kg po载体为10％吐温80水溶液，给药量为2mL \u002F kg 。在食物杯中提供粉状食物，在18小时内以5分钟的间隔连续称重，并使用计算机化系统记录数据。",{"key":236,"value":237},"参考文献","[1].\nFong TM, et al. Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents. J Pharmacol Exp T\n[2].\nLin LS, et al. Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity. J M",[239,245,251,257,263,269],{"slug":240,"cid":241,"name":242,"nameZh":242,"cas":243,"imgSvg":244},"785893332311085000","J-1590970-1","3-(3-溴苯基)-4-(4-...","848310-98-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F034\u002F848310-98-5.svg",{"slug":246,"cid":247,"name":248,"nameZh":248,"cas":249,"imgSvg":250},"785884470203912200","J-23481-8","4-氯溴苄","622-95-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F337\u002F622-95-7.svg",{"slug":252,"cid":253,"name":254,"nameZh":254,"cas":255,"imgSvg":256},"785873175358476300","J-1014298-5","2-(3-溴苯基)乙酸甲酯","150529-73-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F492\u002F150529-73-0.svg",{"slug":258,"cid":259,"name":260,"nameZh":260,"cas":261,"imgSvg":262},"785891192251355100","J-1390691-9","2-甲基-2-[[5-(三氟甲...","913849-17-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F113\u002F913849-17-9.svg",{"slug":264,"cid":265,"name":266,"nameZh":266,"cas":267,"imgSvg":268},"785888333183062000","J-1314152-7","2-羟基-5-三氟甲基吡啶","33252-63-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F270\u002F33252-63-0.svg",{"slug":270,"cid":271,"name":272,"nameZh":272,"cas":273,"imgSvg":274},"785898277403889700","J-50078-0","3-溴苯乙酸","1878-67-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F304\u002F1878-67-7.svg",[],[],[],"2026-08-21T07:51:12.859463Z",false,[281,287,293,299,305,311],{"slug":282,"cid":283,"name":284,"nameZh":285,"cas":286},"785884049620078592","J-22716-8","Cobalt phthalocyanine","酞菁钴","3317-67-7",{"slug":288,"cid":289,"name":290,"nameZh":291,"cas":292},"785883051367337984","J-6801-5","Chromotrope 2B","铬变素2B","548-80-1",{"slug":294,"cid":295,"name":296,"nameZh":297,"cas":298},"785875803232538624","J-1044195-4","Copper(II) ionophore I","铜(II) 离子载体 I","125769-67-7",{"slug":300,"cid":301,"name":302,"nameZh":303,"cas":304},"785897816206610432","J-1946922-3","Carmine alum lake","胭脂红铝","1328-60-5",{"slug":306,"cid":307,"name":308,"nameZh":309,"cas":310},"785875919876132864","J-11268-8","Bis(tri-tert-butylphosphine)palladium(0)","双(三叔丁基膦)钯(0)","53199-31-8",{"slug":312,"cid":313,"name":314,"nameZh":315,"cas":316},"785892233441185792","J-1960577-5","Mupirocin lithium","莫匹罗星锂","73346-79-9",1792624254829,"zh-CN",[]]