[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1109276-6":171,"verified-suppliers-J-1109276-6":400},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.689327,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":188,"ghs":251,"offers":252,"activity":253,"upstream":275,"downstream":306,"customs":319,"safetyRows":332,"synthesis":358,"updatedAt":359,"isProhibited":360,"related":361,"__ts":398,"__lang":399,"__slug":173},"785897635595685888","J-1109276-6","\u002Fimages\u002Fchem_structures_svg\u002F466\u002F147127-20-6.svg","替诺福韦","147127-20-6","C9H14N5O4P","287.212","organic","有机化合物","Organic Compounds",[],[184,185,186,187],"泰诺福韦","(R)-9-(2-磷酸甲氧基丙基)-腺嘌呤","PMPA","(R)-9-(2-磷酸甲氧基丙基)腺嘌呤",[189,194,199,204,209,213,217,220,224,228,232,236,240,244,248],{"label":190,"labelZh":191,"value":192,"prop":193},"Melting Point","熔点","276-280°C","meltingPoint",{"label":195,"labelZh":196,"value":197,"prop":198},"Boiling Point","沸点","616.1±65.0 °C at 760 mmHg","boilingPoint",{"label":200,"labelZh":201,"value":202,"prop":203},"Density","密度","1.8±0.1 g\u002Fcm3","density",{"label":205,"labelZh":206,"value":207,"prop":208},"Flash Point","闪点","326.4±34.3 °C","flashPoint",{"label":210,"labelZh":211,"value":212},"Exact Mass","精确质量","287.078339",{"label":214,"labelZh":215,"value":216},"PSA","其他信息","146.19000",{"label":218,"labelZh":218,"value":219},"LogP","-1.71",{"label":221,"labelZh":222,"value":223},"Appearance","外观性状","白色结晶固体",{"label":225,"labelZh":226,"value":227},"Vapor Pressure","蒸汽压","0.0±1.9 mmHg at 25°C",{"label":229,"labelZh":230,"value":231},"Refractive Index","折射率","1.740",{"label":233,"labelZh":234,"value":235},"Storage Conditions","储存条件","Store at -20°C",{"label":237,"labelZh":238,"value":239},"Additional Property","水溶解性","13.4 mg\u002FmL (25 ºC)",{"label":241,"labelZh":242,"value":243},"Molecular Structure","分子结构","1、 摩尔折射率：64.57\n2、 摩尔体积（cm\n3\n\u002Fmol）：160.1\n3、 等张比容（90.2K）：493.7\n4、 表面张力（dyne\u002Fcm）：90.3\n5、 介电常数（F\u002Fm）：\n6、 偶极距（D）：\n7、 极化率（10\n-24\ncm\n3\n）：25.59",{"label":245,"labelZh":246,"value":247},"Computational Chemistry","计算化学","1.疏水参数计算参考值（XlogP）:无\n2.氢键供体数量:3\n3.氢键受体数量:8\n4.可旋转化学键数量:5\n5.互变异构体数量:3\n6.拓扑分子极性表面积136\n7.重原子数量:19\n8.表面电荷:0\n9.复杂度:354\n10.同位素原子数量:0\n11.确定原子立构中心数量:1\n12.不确定原子立构中心数量:0\n13.确定化学键立构中心数量:0\n14.不确定化学键立构中心数量:0\n15.共价键单元数量:1",{"label":237,"labelZh":249,"value":250},"更多","一、物性数据\n1. 性状：白色固体。白色细微的结晶。\n2. 密度（g\u002FmL,25\u002F4℃）：不确定\n3. 相对蒸汽密度（g\u002FmL,空气=1）：不确定\n4. 熔点（ºC）：279 ºC\n5. 沸点（ºC,0.67kpa或5 mmHg）：不确定\n6. 折射率：不确定\n7. 闪点（ºC）：不确定\n8. 比旋光度（ºC）：不确定\n9. 自燃点或引燃温度（ºC）不确定\n10. 蒸气压（kPa,25ºC）：不确定\n11. 饱和蒸气压（kPa,60ºC）：不确定\n12. 燃烧热（KJ\u002Fmol）：不确定\n13. 临界温度（ºC）：50.3\n14. 临界压力（KPa）：不确定\n15. 油水（辛醇\u002F水）分配系数的对数值：不确定\n16. 爆炸上限（%,V\u002FV）：不确定\n17. 爆炸下限（%,V\u002FV）：不确定\n18. 溶解性：不确定。",null,[],[254,257,260,263,266,269,272],{"key":255,"value":256},"描述","Tenofovir 是一种用于治疗艾滋病毒和慢性乙型肝炎的核苷酸逆转录酶抑制剂。",{"key":258,"value":259},"相关类别","信号通路\n>>\n抗感染\n>>\nHIV\n信号通路\n>>\n抗感染\n>>\n逆转录酶\n研究领域\n>>\n感染",{"key":261,"value":262},"体外研究","替诺福韦在HK-2细胞中显示出对细胞活力的细胞毒性作用,在MTT测定中48和72小时的IC50值分别为9.21和2.77μM。替诺福韦降低HK-2细胞中的ATP水平。替诺福韦(3.0至28.8μM)增加HK-2细胞中的氧化应激和蛋白质羰基化。此外,替诺福韦诱导HK-2细胞凋亡,并且通过线粒体损伤诱导细胞凋亡[1]。配制在0.25％HEC中的替诺福韦和M48U1各自抑制活化的PBMC中R5-向性HIV-1BaL和X4-向性HIV-1IIIb的复制,并抑制几种实验室菌株和源自患者的HIV-1分离株。 M48U1和替诺福韦在0.25％HEC中的组合制剂显示出对抗R5-向性HIV-1BaL感染的协同抗逆转录病毒活性,并且对PBMC无毒性[2]。",{"key":264,"value":265},"体内研究","施用于BLT小鼠的替诺福韦地索普西富马酸盐(20,50,140或300mg\u002Fkg)显示在BLT人源化小鼠的阴道HIV攻击期间的剂量依赖性活性。替诺福韦地索普西富马酸盐(50,140,300 mg\u002Fkg)显着降低BLT小鼠的HIV传播[3]。替诺福韦地索普西富马酸盐(0.5,1.5或5.0mg\u002Fkg \u002F天,po)诱导长期感染WHV的土拨鼠血清病毒血症的剂量依赖性下降。替诺福韦地索普西富马酸盐给药在慢性HBV感染的土拨鼠模型中是安全有效的[4]。",{"key":267,"value":268},"细胞实验","将细胞接种到48孔组织培养板（39,000个细胞\u002F mL）中并使其生长48小时，然后用载体或替诺福韦处理。在治疗期后，使用MTT测定评估细胞活力。 MTT测定依赖于四唑鎓染料3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化物（MTT）通过NAD（P）H依赖性氧化还原酶转化为甲[1]。",{"key":270,"value":271},"动物实验","将20只成年慢性WHV携带者土拨鼠按年龄，性别，体重和血清GGT活性分成5个治疗组，每组4只动物：（i）替诺福韦地索普西富马酸盐，每天15.0 mg \u002F kg，（ii）替诺福韦Disoproxil富马酸盐5.0mg \u002F kg \u002F天，（iii）替诺福韦地索普西富马酸盐1.5mg \u002F kg \u002F天，（iv）替诺福韦地索普西富马酸盐0.5mg \u002F kg \u002F天，和（v）安慰剂对照。土拨鼠每天治疗4周，停止药物治疗后再观察12周[4]。",{"key":273,"value":274},"参考文献","[1].\nMurphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3).\n[2].\nMusumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018.\n[3].\nWahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098.\n[4].\nMenne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8.",[276,282,288,294,300],{"slug":277,"cid":278,"name":279,"nameZh":279,"cas":280,"imgSvg":281},"785882171037454300","J-1130660-7","(R)-9-[2-(二乙基膦酰...","180587-75-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F388\u002F180587-75-1.svg",{"slug":283,"cid":284,"name":285,"nameZh":285,"cas":286,"imgSvg":287},"785897632995217400","J-1522642-2","对甲苯磺酰氧甲基膦酸二乙酯","31618-90-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F415\u002F31618-90-3.svg",{"slug":289,"cid":290,"name":291,"nameZh":291,"cas":292,"imgSvg":293},"785895992351264800","J-1512823-2","(R)-9-(2-羟基丙基)腺嘌呤","14047-28-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F454\u002F14047-28-0.svg",{"slug":295,"cid":296,"name":297,"nameZh":297,"cas":298,"imgSvg":299},"785895203696283600","J-1508113-9","(R)-1-((5-氨基-6-...","17435-30-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F231\u002F17435-30-2.svg",{"slug":301,"cid":302,"name":303,"nameZh":303,"cas":304,"imgSvg":305},"785895203746615300","J-1508114-0","(R)-1-(6-氯-9H-嘌...","180587-74-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F426\u002F180587-74-0.svg",[307,313],{"slug":308,"cid":309,"name":310,"nameZh":310,"cas":311,"imgSvg":312},"785897645154504700","J-1986851-8","富马酸替诺福韦酯","202138-50-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F058\u002F202138-50-9.svg",{"slug":314,"cid":315,"name":316,"nameZh":316,"cas":317,"imgSvg":318},"785884132377890800","J-1957155-3","替诺福韦艾拉酚胺","379270-37-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F306\u002F379270-37-8.svg",[320,323,326,329],{"key":321,"value":322},"海关编码","2933990090",{"key":324,"value":325},"中文概述","2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":327,"value":328},"申报要素","品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期",{"key":330,"value":331},"Summary","2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[333,336,339,342,345,348,351,354,357],{"key":334,"value":335},"危害码 (欧洲)","C",{"key":337,"value":338},"风险声明 (欧洲)","R34:Causes burns.",{"key":340,"value":341},"安全声明 (欧洲)","S22-S26-S27-S36\u002F37\u002F39-S45",{"key":343,"value":344},"危险品运输编码","UN 3261 8\u002FPG 2",{"key":346,"value":347},"WGK德国","3",{"key":349,"value":350},"RTECS号","DB8930000",{"key":352,"value":353},"包装等级","III",{"key":355,"value":356},"危险类别","8",{"key":321,"value":322},"\u003Cp> 1.将亚磷酸二乙酯、多聚甲醛和三乙胺溶于甲苯，在氮气保护下反应，回流。反应完全后冷却，缓慢加入对甲苯磺酰氯和三乙胺，反应得到对甲苯磺酰氧甲基膦酸二乙酯。在氮气保护下，将（犛）-缩水甘油、5％钯碳、乙醇和氢氧化钠水溶液混合，进行加氢，得到（犚）-1,2-丙二醇。加入碳酸二乙酯和乙醇钠的乙醇溶液，反应得（犚）-1,2-丙二醇碳酸酯。将其和腺嘌呤、对甲苯磺酰氧甲基膦酸二乙酯、氢氧化钠溶于二甲基甲酰胺，反应得（犚）-9-［2-（二乙基膦酰基甲氧基）丙基］腺嘌呤。将其溶于乙腈，加溴三甲基硅烷，得泰诺福韦粗品，重结晶得纯品。将泰诺福韦和1-甲基-2-吡咯烷酮、三乙胺混合加入碳酸氯甲基丙基酯反应，再用富马酸酸化，得富马酸泰诺福韦双特戊酰氧基甲酯。\u003Cbr \u002F>\u003Cbr \u002F> \u003C\u002Fp>","2026-08-21T07:51:12.859463Z",false,[362,368,374,380,386,392],{"slug":363,"cid":364,"name":365,"nameZh":366,"cas":367},"785872087020474368","J-1990991-8","Alizarin Yellow R","茜素黄R","2243-76-7",{"slug":369,"cid":370,"name":371,"nameZh":372,"cas":373},"785894562861158400","J-38022-5","Luteolin","木犀草素","491-70-3",{"slug":375,"cid":376,"name":377,"nameZh":378,"cas":379},"785883053602902016","J-6816-1","Neutral Red","中性红","553-24-2",{"slug":381,"cid":382,"name":383,"nameZh":384,"cas":385},"785883839846158336","J-9665-6","propineb","丙森锌","12071-83-9",{"slug":387,"cid":388,"name":389,"nameZh":390,"cas":391},"785889602677248000","J-1959100-5","Ataluren","阿塔鲁伦","775304-57-9",{"slug":393,"cid":394,"name":395,"nameZh":396,"cas":397},"785898319372095488","J-1987692-2","Sodium starch glycolate","羧甲基淀粉钠","9063-38-1",1792668302771,"zh-CN",[]]