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3）在100％DMSO中接受3mg \u002F kg的epoD注射，然后在4,6和10天后进行安乐死。使用LC-MS \u002F MS方案测定脑和血液样品中的epoD水平。每周ip注射1mg \u002F kg epoD，3mg \u002F kg epoD或载体（DMSO），给予3个月大的PS19 tau Tg小鼠或3个月大的非Tg同窝小鼠组（n = 10-13），共3个月。监测动物的异常行为或窘迫的迹象，并每周称重。在最后给药后，小鼠经历运动功能和认知测试。安乐死后，恢复大脑和视神经（ON）用于免疫组织化学分析。来自每组的一组小鼠也进行尸检评估，记录器官重量。",{"key":246,"value":247},"参考文献","[1].\nKonner J, et al. 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