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反应曲线，单独或与各种剂量的纳曲吲哚组合。在温育结束时，向每个孔中加入10μLWST-1细胞增殖试剂，并将板放回培养箱中1小时。然后测量吸光度[2]。",{"key":252,"value":253},"动物实验","大鼠：在20日龄大鼠中测试新生儿纳曲吲哚治疗对旷场活动的影响。动物长期注射生理盐水或纳曲吲哚（1 mg \u002F kg，sc）（从出生到第19天），并在停止治疗后1天研究纳曲吲哚的急性作用（1 mg \u002F kg，ip） [5]。小鼠：将Naltrindole溶解在蒸馏水中以制备3mg \u002F mL溶液，并且每天向小鼠注射10mL \u002F kg。将人RPMI 8226多发性骨髓瘤细胞皮下接种到SCID小鼠的两侧（每个侧翼1000万个细胞）。 8天后，将12只小鼠分成两组，每组6只小鼠：注射媒介物和注射纳曲吲哚（30mg \u002F kg）。动物每天给药36天，并且用数字卡尺每周两次测量体重和异种移植肿瘤[2]。",{"key":255,"value":256},"参考文献","[1].\nRaynor K, et al. Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4.\n[2].\nMundra JJ, et al. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther. 2012 Aug;342(2):273-87.\n[3].\nChen YL, et al. Inhibition of akt\u002Fprotein kinase B signaling by naltrindole in small cell lung cancer cells.\n[4].\nPortoghese PS, et al. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist. Eur J Pharmacol. 1988 Jan 27;146(1):185-6.\n[5].\nFernández B, et al. Postnatal naltrindole treatments induce behavioural modifications in preweanling rats. 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