[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-10494-9":169,"verified-suppliers-J-10494-9":384},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.679814,"live",{"rows":9,"total":167,"current":5,"size":168},[10,33,45,60,73,84,96,111,121,133,145,156],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-6","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-2","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-6","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],10,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-6","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},6,"中国",{"slug":74,"cid":75,"imgSvg":76,"name":77,"nameZh":78,"cas":79,"formula":80,"iupac":77,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":81,"offersCount":25,"supplierCount":25,"bestOffer":82},"785871840001134592","J-982001-3","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":83,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":85,"cid":86,"imgSvg":87,"name":88,"nameZh":89,"cas":90,"formula":91,"iupac":88,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":92,"offersCount":93,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-7","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlLiO2",[23],7,3,{"unitPrice":94,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":94,"supplierCount":5,"bestOffer":109},"785871830249377792","J-6931-8","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[108],"Made to Order",{"unitPrice":110,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},0.56,{"slug":112,"cid":113,"imgSvg":114,"name":115,"nameZh":116,"cas":117,"formula":118,"iupac":115,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":119,"offersCount":69,"supplierCount":25,"bestOffer":120},"785871842446413824","J-1960944-0","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":122,"cid":123,"imgSvg":124,"name":125,"nameZh":126,"cas":127,"formula":128,"iupac":125,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":129,"offersCount":24,"supplierCount":25,"bestOffer":130},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":131,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":134,"cid":135,"imgSvg":136,"name":137,"nameZh":138,"cas":139,"formula":140,"iupac":137,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":141,"offersCount":142,"supplierCount":5,"bestOffer":143},"785871842647740416","J-1333345-4","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],8,{"unitPrice":144,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},11,{"slug":146,"cid":147,"imgSvg":148,"name":149,"nameZh":150,"cas":151,"formula":152,"iupac":149,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":153,"offersCount":57,"supplierCount":94,"bestOffer":154},"785871842698072064","J-814953-9","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],{"unitPrice":155,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":157,"cid":158,"imgSvg":159,"name":160,"nameZh":161,"cas":162,"formula":163,"iupac":160,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":164,"offersCount":94,"supplierCount":5,"bestOffer":165},"785871863254355968","J-1990080-2","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[108],{"unitPrice":166,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,12,{"slug":170,"cid":171,"imgSvg":172,"name":173,"nameZh":174,"cas":175,"formula":176,"iupac":173,"mdl":21,"mw":177,"category":178,"categoryName":179,"categoryEnName":180,"industry":21,"tags":181,"synonyms":182,"properties":185,"ghs":227,"offers":228,"activity":229,"upstream":239,"downstream":275,"customs":288,"safetyRows":289,"toxicity":305,"synthesis":306,"updatedAt":307,"isProhibited":308,"related":309,"__ts":382,"__lang":383,"__slug":171},"785875574911406080","J-10494-9","\u002Fimages\u002Fchem_structures_svg\u002F375\u002F124937-51-5.svg","Tolterodine","托特罗定","124937-51-5","C22H31NO","325.488","organic","有机化合物","Organic Compounds",[],[183,184],"(R)-2-[3-(二异丙胺基)-1-苯丙基]-4-甲基苯酚","2-[3-[二(1-甲基乙基)氨基]-1-苯丙基]-4-甲基苯酚",[186,191,196,201,205,208,211,215,219,223],{"label":187,"labelZh":188,"value":189,"prop":190},"Boiling Point","沸点","442.2±45.0 °C at 760 mmHg","boilingPoint",{"label":192,"labelZh":193,"value":194,"prop":195},"Density","密度","1.0±0.1 g\u002Fcm3","density",{"label":197,"labelZh":198,"value":199,"prop":200},"Flash Point","闪点","192.1±27.4 °C","flashPoint",{"label":202,"labelZh":203,"value":204},"Exact Mass","精确质量","325.240570",{"label":206,"labelZh":206,"value":207},"PSA","23.47000",{"label":209,"labelZh":209,"value":210},"LogP","5.77",{"label":212,"labelZh":213,"value":214},"Vapor Pressure","蒸汽压","0.0±1.1 mmHg at 25°C",{"label":216,"labelZh":217,"value":218},"Refractive Index","折射率","1.548",{"label":220,"labelZh":221,"value":222},"Storage Conditions","储存条件","-20°C Freezer",{"label":224,"labelZh":225,"value":226},"Molecular Structure","分子结构","1、 摩尔折射率：98.34\n2、 摩尔体积（cm\n3\n\u002Fmol）：307.8\n3、 等张比容（90.2K）：768.5\n4、 表面张力（dyne\u002Fcm）：38.8\n5、 极化率（10-24cm3）：38.98",null,[],[230,233,236],{"key":231,"value":232},"描述","Tolterodine(PNU-200583)是毒蕈碱型受体(mAChR)拮抗剂。",{"key":234,"value":235},"相关类别","信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\n由mAChR\n信号通路\n>>\n神经信号通路\n>>\nmAChR\n研究领域\n>>\n神经疾病",{"key":237,"value":238},"参考文献","[1].\nNilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002 May;90(5):260-7.\n[2].\nAndersson SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug Metab Dispos. 1998 Jun;26(6):528-35.\n[3].\nCappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008 Jan 28;579(1-3):225-8.",[240,246,251,257,263,269],{"slug":241,"cid":242,"name":243,"nameZh":243,"cas":244,"imgSvg":245},"785872016551972900","J-1064984-0","二异丙胺","108-18-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F151\u002F108-18-9.svg",{"slug":247,"cid":248,"name":174,"nameZh":174,"cas":249,"imgSvg":250},"785895490666369000","J-1967169-3","848768-06-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F358\u002F848768-06-9.svg",{"slug":252,"cid":253,"name":254,"nameZh":254,"cas":255,"imgSvg":256},"785876340149588000","J-1075646-4","6-甲基-4-苯基色满-2-酮","40546-94-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F333\u002F40546-94-9.svg",{"slug":258,"cid":259,"name":260,"nameZh":260,"cas":261,"imgSvg":262},"785881411767767000","J-1090283-7","2-甲氧基-5-甲基-N,N-...","124935-88-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F170\u002F124935-88-2.svg",{"slug":264,"cid":265,"name":266,"nameZh":266,"cas":267,"imgSvg":268},"785891378029662200","J-29471-3","对甲酚","106-44-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F374\u002F106-44-5.svg",{"slug":270,"cid":271,"name":272,"nameZh":272,"cas":273,"imgSvg":274},"785882013130297300","J-1121797-3","(4R)-6-甲基-4-苯基色满-2-酮","827007-19-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F304\u002F827007-19-2.svg",[276,282],{"slug":277,"cid":278,"name":279,"nameZh":279,"cas":280,"imgSvg":281},"785897731120959500","J-1986966-0","(R)-5-羟甲基托特罗定","207679-81-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F118\u002F207679-81-0.svg",{"slug":283,"cid":284,"name":285,"nameZh":285,"cas":286,"imgSvg":287},"785891804858814500","J-1960056-7","弗斯特罗定","286930-02-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F307\u002F286930-02-7.svg",[],[290,293,296,299,302],{"key":291,"value":292},"危害码 (欧洲)","Xn,Xi",{"key":294,"value":295},"风险声明 (欧洲)","R22:Harmful if swallowed.",{"key":297,"value":298},"安全声明 (欧洲)","S36\u002F37\u002F39",{"key":300,"value":301},"危险品运输编码","1987",{"key":303,"value":304},"WGK德国","2","\u003Ctd>\n\n\u003Cp>\u003Cstrong>托特罗定毒理学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp>酒石酸托特罗定：雄性小鼠静脉注射LD50：10～20mg\u002Fkg\u003C\u002Fp>\n\u003Cp>\u003Cbr \u002F>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F124937-51-5_123931.html#duXinDiv\">托特罗定毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Cp>反式内桂酸(100g,675mmol)加到反应瓶中，加入预热到60℃的对甲苯酚(76.6g,708mmol),然后加入浓硫酸(13.0ml,243mmol)。加毕，马上加热到122.5℃，然后在120~125℃搅拌至反应完全，约6h。冷却至100℃，倾入预热过的分液漏斗。分出下层酸层，加入280ml甲苯、50ml水和10ml47％的碳酸钾溶液。如有需要，可用47％的碳酸钾将水层的狆犎值调至5~8。分出有机层，用50ml水洗，减压浓缩至大约150ml。加入350ml异丙醇，浓缩至剩350ml。加入150ml异丙醇，浓缩至剩350ml。再加入150ml异丙醇，再浓缩至剩350ml。在快速搅拌下冷却至30~40℃，使形成结晶，并继续搅拌。然后冷却至0~5℃，并保持1h。过滤收集结晶，用0~5℃的200ml异丙醇分批洗，如最终的洗液仍有颜色，则继续洗，直至洗液无色。在60℃和减压下干燥，得3,4-二氢-6-甲基-4-苯基-2H-苯并吡喃-2-酮，熔点83～85℃。3,4-二氢-6-甲基-4--苯基-2H-苯并吡-2-酮(100.0g,420.2mmol)加到500ml甲苯中，冷至－21℃和在氮气保护下，在2h中缓慢加入二异丁基氢铝的甲苯溶液(DIBAL,1.5mol\u002FL,290ml,435mmol),并维持反应温度为－20～－25℃。当反应完全后，在－20～－25℃加入45ml乙酸乙酯。然后加入500ml\u003Cbr \u002F>23％的柠檬酸，所成溶液在45～50℃搅拌1h(或在20～25℃搅拌过夜）。分出有机层，用2×300ml水洗后，减压浓缩至剩250ml.加入500ml甲醇，再浓缩至250ml，重复操作。然后浓缩至油状物，静置结晶，得到3,4-二氢-6-甲基-4-苯基-2H-苯并吡喃-2-醇，直接用于下步反应。100g3,4-二氢-6-甲基-4-苯基-2H-苯并吡喃-2-醇在500ml醇的溶液，在氮气保护下，缓慢加入22g5％的钯-炭(1-5mmol)。加入二异丙胺(147.0ml,1.05mol),在0.32～0.35MPa和48℃下加氢至完全。通常反应约10h，也可反应过夜。冷却，移出反应器，再用150ml甲醇清洗反应器。清洗液和反应液合并，过滤，滤液浓缩，再加入乙酸乙酯至700ml，加热至55℃。在15mol中，加入52.5ml浓盐酸。缓慢冷却至－15～－20℃，并保持1h。过滤收集固体，真空干燥过夜，得盐酸托特罗定，熔点199～201℃。\u003C\u002Fp>\u003Cp>\u003Cbr \u002F>\u003Cbr \u002F>\u003C\u002Fp>","2026-08-21T07:51:12.859463Z",false,[310,316,322,328,334,340,346,352,358,364,370,376],{"slug":311,"cid":312,"name":313,"nameZh":314,"cas":315},"785894729387610112","J-1504350-2","10-(2-(Diethylamino)propanoyl)phenothiazine","10-(α-二乙氨基丙酰基)吩噻嗪","13012-66-3",{"slug":317,"cid":318,"name":319,"nameZh":320,"cas":321},"785893706199732224","J-1114778-7","Methyl Orange","甲基橙","547-58-0",{"slug":323,"cid":324,"name":325,"nameZh":326,"cas":327},"785898934651326464","J-1306400-1","Thiodiazole copper","噻菌铜","3234-61-5",{"slug":329,"cid":330,"name":331,"nameZh":332,"cas":333},"785872688496250880","J-1992713-0","Acediasulfone sodium","醋地砜钠","127-60-6",{"slug":335,"cid":336,"name":337,"nameZh":338,"cas":339},"785882574428835840","J-1094601-7","Methylene Blue","亚甲基蓝","61-73-4",{"slug":341,"cid":342,"name":343,"nameZh":344,"cas":345},"785898371956084736","J-50383-3","alpha-Amylase","α-淀粉酶","9000-90-2",{"slug":347,"cid":348,"name":349,"nameZh":350,"cas":351},"785897801883062272","J-47964-1","Fluorescein","荧光素","2321-07-5",{"slug":353,"cid":354,"name":355,"nameZh":356,"cas":357},"785893129814282240","J-1962350-8","Phytosphingosine","糖脂","554-62-1",{"slug":359,"cid":360,"name":361,"nameZh":362,"cas":363},"785882530409615360","J-1955871-5","Febuxostat","非布索坦","144060-53-7",{"slug":365,"cid":366,"name":367,"nameZh":368,"cas":369},"785892364030840832","J-1381949-3","Alcloxa","铝克洛沙","1317-25-5",{"slug":371,"cid":372,"name":373,"nameZh":374,"cas":375},"785875984183201792","J-11597-9","Aflatoxin B1","黄曲霉毒素B1","1162-65-8",{"slug":377,"cid":378,"name":379,"nameZh":380,"cas":381},"785883191893299200","J-1367925-9","Pigment Yellow 150","颜料黄150","68511-62-6",1794252194907,"zh-CN",[]]