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BMS-378806以约1：1的化学计量直接与gp120结合,具有与可溶性CD4相似的结合亲和力。通过使用携带化合物选择的抗性取代或gp120-CD4接触位点突变的HIV-1 gp120变体,将潜在的BMS-378806靶位点定位于gp120的CD4结合口袋内的特定区域[3]。",{"key":240,"value":241},"体内研究","在毒理学研究中,BMS-378806在大鼠中以100mg\u002Fkg \u002F天的剂量耐受2周,并且在狗中以90mg\u002Fkg的剂量耐受10天。当在溶液或悬浮液制剂中施用BMS-378806时,在5和25mpk的剂量之间观察到AUC和Cmax的剂量成比例增加。在所有三个物种中,药物的血浆水平超过了体外半数最大程度地抑制病毒复制所需的浓度。 BMS-378806的分布容积范围为0.4至0.6 L\u002Fkg,表明分配超出血浆;然而,对大鼠脑水平的检查显示CNS渗透最小[1]。",{"key":243,"value":244},"激酶实验","为了测量gp120-CD4结合，首先通过D7324抗体将野生型或变体gp120蛋白质捕获到平板上。通过将sCD4添加至涂有gp120的平板来启动CD4结合。为了确定BMS-378806与sCD4竞争gp120结合的能力，将该化合物与sCD4同时加入，并在缓冲液C（50mM Tris-HCl [pH 7.5]，100mM NaCl，1％牛血清中）进行反应。白蛋白）在室温下保持2小时。用缓冲液B（20mM Tris-HCl，500mM NaCl，0.05％Tween 20 [pH 7.5]）洗涤后，用OKT4抗体（0.36μg\u002F mL）和山羊抗小鼠过氧化物酶缀合物检测结合的CD4。用3,3'，5,5'-四甲基联苯胺显色底物检测结合的抗体过氧化物酶[3]。",{"key":246,"value":247},"动物实验","大鼠，狗和猴[1]总结了BMS-378806在大鼠，狗和食蟹猴中的药代动力学特性。 BMS-378806在大鼠中的口服生物利用度，以PEG 400 \u002F EtOH（90：10v \u002F v）的溶液形式给药，以5mg \u002F kg的剂量为19％，而游离碱的含水结晶悬浮液为0.75％。 （w \u002F w）Methocel A4M Premium以相同剂量口服给药，相对生物利用度为61％。",{"key":249,"value":250},"参考文献","[1].\nWang T, et al. Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. J Med Chem. 2003 Sep 25;46(20):4236-9.\n[2].\nHo HT, et al. Envelope conformational changes induced by human immunodeficiency virus type 1 attachment inhibitors prevent CD4 binding and downstream entry events. J Virol. 2006 Apr;80(8):4017-25.\n[3].\nGuo Q, et al. Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions. 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